Title:
METHODS FOR ACTIVATING INACTIVE GENES AND METHODS FOR ALTERING THE RATE OF DEVELOPMENT OF CELLS, TISSUES AND ORGANISMS
Document Type and Number:
WIPO Patent Application WO1998054310
Kind Code:
A3
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Inventors:
TAN YUYING (US)
Application Number:
PCT/US1998/010006
Publication Date:
March 04, 1999
Filing Date:
May 15, 1998
Export Citation:
Assignee:
ANTICANCER INC (US)
International Classes:
A01K67/027; A61K48/00; C12N15/67; (IPC1-7): C12N15/00
Domestic Patent References:
| WO1996040284A1 | 1996-12-19 |
Other References:
HOFFMAN R.M.: "Methioninase: a therapeutic for diseases related to altered methionine methabolism and transmethylation: cancer, heart disease, obesity aging and Parkinson's disease", HUMAN CELL, vol. 10, no. 1, March 1997 (1997-03-01), JP, pages 69 - 80, XP002082379
TAN Y. ET AL.: "Serum Methionine depletion without side effects by methioninase in metastatic breast cancer patients", ANTICANCER RESEARCH, vol. 16, no. 6c, November 1996 (1996-11-01), GR, pages 3937 - 3942, XP002082380
TAN Y. ET AL.: "Overexpression and large-scale production of recombinant l-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy", PROTEIN EXPRESSION AND PURIFICATION, vol. 9, no. 2, March 1997 (1997-03-01), us, pages 233 - 245, XP002082381
TURKER M.S. ET AL.: "The mouse APRT gene as a model for studying epigenetic gene inactivation", ADVANCEDS IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol. 370, 1995, US, pages 647 - 652, XP002082382
HOFFMAN R.M. AND TAN Y.: "Anti-methionine therapy as a potential universal modulator for anti-tumor and anti-metastatic therapy", CLINICAL AND EXPERIMENTAL METASTASIS, vol. 14,supp.1, September 1996 (1996-09-01), London, GB, pages 85, XP002082383
CHIU C.P., BLAU H.M.: "5-azacytidine permits gene activation in a previously noninducible cell type", CELL, vol. 40, no. 2, February 1985 (1985-02-01), US, pages 417 - 424, XP002082384
MAKOS M. ET AL.: "Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 89, March 1992 (1992-03-01), WASHINGTON US, pages 1929 - 1933, XP002082385
TAN Y. ET AL.: "Serum Methionine depletion without side effects by methioninase in metastatic breast cancer patients", ANTICANCER RESEARCH, vol. 16, no. 6c, November 1996 (1996-11-01), GR, pages 3937 - 3942, XP002082380
TAN Y. ET AL.: "Overexpression and large-scale production of recombinant l-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy", PROTEIN EXPRESSION AND PURIFICATION, vol. 9, no. 2, March 1997 (1997-03-01), us, pages 233 - 245, XP002082381
TURKER M.S. ET AL.: "The mouse APRT gene as a model for studying epigenetic gene inactivation", ADVANCEDS IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol. 370, 1995, US, pages 647 - 652, XP002082382
HOFFMAN R.M. AND TAN Y.: "Anti-methionine therapy as a potential universal modulator for anti-tumor and anti-metastatic therapy", CLINICAL AND EXPERIMENTAL METASTASIS, vol. 14,supp.1, September 1996 (1996-09-01), London, GB, pages 85, XP002082383
CHIU C.P., BLAU H.M.: "5-azacytidine permits gene activation in a previously noninducible cell type", CELL, vol. 40, no. 2, February 1985 (1985-02-01), US, pages 417 - 424, XP002082384
MAKOS M. ET AL.: "Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 89, March 1992 (1992-03-01), WASHINGTON US, pages 1929 - 1933, XP002082385
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