Title:
METHODS FOR RESOLUTION OF THE MIXTURE OF THE OPTICAL ISOMERS, ESPECIALLY THE RACEMATE OF PINOCEMBRIN
Document Type and Number:
WIPO Patent Application WO/2009/067904
Kind Code:
A1
Abstract:
Methods for resolution of the mixture of the optical isomers, especially the
racemate of pinocembrin, using chiral primary amines or chiral sulfenamides.
(R)-(+)-pinocembrin obtained by said methods.
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Inventors:
WU SONG (CN)
DU GUANHUA (CN)
YUAN YUE (CN)
YANG QINGYUN (CN)
GAO MEI (CN)
QI YAN (CN)
TONG YUANFENG (CN)
WANG YUEHUA (CN)
DU GUANHUA (CN)
YUAN YUE (CN)
YANG QINGYUN (CN)
GAO MEI (CN)
QI YAN (CN)
TONG YUANFENG (CN)
WANG YUEHUA (CN)
Application Number:
PCT/CN2008/072983
Publication Date:
June 04, 2009
Filing Date:
November 07, 2008
Export Citation:
Assignee:
CSPC ZHONGQI PHARMACEUTICAL TE (CN)
INST MATERIA MEDICA CAMS (CN)
WU SONG (CN)
DU GUANHUA (CN)
YUAN YUE (CN)
YANG QINGYUN (CN)
GAO MEI (CN)
QI YAN (CN)
TONG YUANFENG (CN)
WANG YUEHUA (CN)
INST MATERIA MEDICA CAMS (CN)
WU SONG (CN)
DU GUANHUA (CN)
YUAN YUE (CN)
YANG QINGYUN (CN)
GAO MEI (CN)
QI YAN (CN)
TONG YUANFENG (CN)
WANG YUEHUA (CN)
International Classes:
C07D311/36; C07B57/00
Foreign References:
| EP1389606A1 | 2004-02-18 | |||
| JP2005176758A | 2005-07-07 |
Other References:
DING, YUANQING ET AL.: "Theoretical Calculation of Electronic Circular Dichroism of the Rotationally Restricted 3,8''-Biflavonoid Morelloflavone.", JOURNAL OF ORGANIC CHEMISTRY, vol. 72, no. 24, 24 October 2007 (2007-10-24), pages 9010 - 9017, XP008136495
HOLDER, SHELDON ET AL.: "Characterization of a potent and selectivesmall-molecule inhibitor of the PIM1 kinase.", MOLECULAR CANCER THERAPEUTICS, vol. 6, no. 1, January 2007 (2007-01-01), pages 163 - 172, XP008136491
HOLDER, SHELDON ET AL.: "Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase.", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, no. 19, 14 June 2007 (2007-06-14), pages 6463 - 6473, XP022192449
CACCAMESE, S. ET AL.: "High-performance liquid chromatographic separation and chiroptical properties of the enantiomers of naringenin and other flavanones.", JOURNAL OF CHROMATOGRAPHY A, vol. 1076, no. 1-2, 2005, pages 155 - 162, XP004904088
ASZTEMBORSKA, M. ET AL.: "Separation of some chiral flavanones by micellar electrokinetic chromatography.", ELECTROPHORESIS, vol. 24, no. 15, 2003, pages 2527 - 2531, XP008136497
LEPRI, L. ET AL.: "Reversed-phase planar chromatography of racemic flavanones.", JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, vol. 22, no. 1, 1999, pages 105 - 118, XP008136499
See also references of EP 2221300A4
DUAN YABO ET AL., CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 16, no. 6, 2006, pages 342 - 346
HOLDER, SHELDON ET AL.: "Characterization of a potent and selectivesmall-molecule inhibitor of the PIM1 kinase.", MOLECULAR CANCER THERAPEUTICS, vol. 6, no. 1, January 2007 (2007-01-01), pages 163 - 172, XP008136491
HOLDER, SHELDON ET AL.: "Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase.", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, no. 19, 14 June 2007 (2007-06-14), pages 6463 - 6473, XP022192449
CACCAMESE, S. ET AL.: "High-performance liquid chromatographic separation and chiroptical properties of the enantiomers of naringenin and other flavanones.", JOURNAL OF CHROMATOGRAPHY A, vol. 1076, no. 1-2, 2005, pages 155 - 162, XP004904088
ASZTEMBORSKA, M. ET AL.: "Separation of some chiral flavanones by micellar electrokinetic chromatography.", ELECTROPHORESIS, vol. 24, no. 15, 2003, pages 2527 - 2531, XP008136497
LEPRI, L. ET AL.: "Reversed-phase planar chromatography of racemic flavanones.", JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, vol. 22, no. 1, 1999, pages 105 - 118, XP008136499
See also references of EP 2221300A4
DUAN YABO ET AL., CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 16, no. 6, 2006, pages 342 - 346
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (Scitech PlaceNo.22, Jian Guo Men Wai Ave., Chao Yang District, Beijing 4, CN)
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