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Title:
METHODS OF TREATING CANCERS USING PD-1 AXIS BINDING ANTAGONISTS AND ANTI-GPC3 ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2017/159699
Kind Code:
A1
Abstract:
The disclosure provides compositions and methods for treating cancers. The methods comprising administering a PD-1 axis binding antagonist and an anti-GPC3 antibody. The compositions comprising a pharmaceutical composition for treating cancer which comprises a PD-1 axis binding antagonist and an anti-GPC3 antibody. Also disclosed are a pharmaceutical composition to be used in combination with a PD-1 axis binding antagonist for treating cancer which comprises an anti-GPC3 antibody as the active ingredient; and a pharmaceutical composition to be used in combination with an anti-GPC3 antibody for treating cancer which comprises as the active ingredient a PD-1 axis binding antagonist.

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Inventors:
ENDO MIKA (JP)
KATO ATSUHIKO (JP)
OHTOMO TOSHIHIKO (JP)
ADACHI KENJI (JP)
KINOSHITA YASUKO (JP)
NARITA YOSHINORI (JP)
Application Number:
PCT/JP2017/010267
Publication Date:
September 21, 2017
Filing Date:
March 14, 2017
Export Citation:
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Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
GENENTECH INC (US)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C07K16/30
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Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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