METTL3 INHIBITOR COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF

Title:

METTL3 INHIBITOR COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2024/056099

Kind Code:

A1

Abstract:

Provided is use of a compound of formula I, formula I', or formula I", and a tautomer, a stereoisomer, or a pharmaceutically acceptable salt thereof as an METTL3 inhibitor. The compound can be used for treating a condition and a disease related to the methyltransferase activity of METTL3/METTL14.

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Inventors:

LI ZIZHONG (CN)
GAO HUI (CN)
WANG TING (CN)
CHANG LEI (CN)
DING SHENG (CN)

Application Number:

PCT/CN2023/119505

Publication Date:

March 21, 2024

Filing Date:

September 18, 2023

Export Citation:

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Assignee:

GLOBAL HEALTH DRUG DISCOVERY INST (CN)

International Classes:

C07D471/04; A61K31/437; A61K31/4375; A61P25/00; A61P29/00; A61P31/00; A61P35/00; A61P35/02; C07D519/00

Domestic Patent References:

WO2023104209A1	2023-06-15
WO2021111124A1	2021-06-10
WO2022074379A1	2022-04-14

Foreign References:

CN113905787A

2022-01-07

Attorney, Agent or Firm:

BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)

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