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Title:
MORPHOLINYL QUINAZOLINE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/041519
Kind Code:
A1
Abstract:
Provided is a morpholinyl quinazoline compound represented by formula I, or a pharmaceutically acceptable salt, a solvate, a polymorph or a prodrug thereof. The morpholinyl quinazoline compound has a dual inhibitory activity against PI3Kδ and HDAC, and is prospective for better therapeutic effects and broader applications.

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Inventors:
XU ZUSHENG (CN)
LOU YANGTONG (CN)
XIE TIEGANG (CN)
XU LINLIN (CN)
Application Number:
PCT/CN2023/114208
Publication Date:
February 29, 2024
Filing Date:
August 22, 2023
Export Citation:
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Assignee:
SHANGHAI YINGLI PHARM CO LTD (CN)
International Classes:
C07D401/14; A61K31/5377; A61P35/00
Domestic Patent References:
WO2018237007A12018-12-27
Foreign References:
CN104557872A2015-04-29
CN103374021A2013-10-30
CN102970868A2013-03-13
CN111646973A2020-09-11
CN110950844A2020-04-03
CN113444073A2021-09-28
CN101889015A2010-11-17
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