MUTANT ACYL-COA SYNTHETASE AND PRODUCTION METHOD THEREFOR

Title:

MUTANT ACYL-COA SYNTHETASE AND PRODUCTION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2023/190639

Kind Code:

A1

Abstract:

A recombinant acyl-CoA synthetase (ACS) is a polypeptide having an amino acid sequence in which at least one among lysine at the 173rd position and lysine at the 174th position in the amino acid sequence of a wild-type ACS represented by SEQ ID NO: 1 is substituted with another amino acid. Accordingly, when an ACS is produced by a genetic engineering method, the rupture of the ACS can be suppressed at the time of being expressed in a host or recovered from a host, and thus a mutant ACS can be favorably recovered from the host. Consequently, a mutant ACS which can be further favorably recovered from a host is obtained.

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Inventors:

TOBE RYUTA (JP)
FUKUSHIMA HIKARU (JP)

Application Number:

PCT/JP2023/012730

Publication Date:

October 05, 2023

Filing Date:

March 29, 2023

Export Citation:

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Assignee:

NIPRO CORP (JP)

International Classes:

C12N5/10; C12N1/15; C12N1/19; C12N1/21; C12N9/10; C12N15/54; C12P21/02

Foreign References:

JP2015163050A

2015-09-10

Other References:

L. FRAHM JENNIFER, LI LEI O, GREVENGOED TRISHA J, COLEMAN ROSALIND A: "Phosphorylation and Acetylation of Acyl-Coa Synthetase- I", JOURNAL OF PROTEOMICS & BIOINFORMATICS, vol. 04, no. 07, 13 September 2013 (2013-09-13), pages 129 - 133, XP093094384, DOI: 10.4172/jpb.1000180
SEN PROGGA; KAN CHIN FUNG KELVIN; SINGH AMAR B.; RIUS MONICA; KRAEMER FREDRIC B.; SZTUL ELIZABETH; LIU JINGWEN: "Identification of p115 as a novel ACSL4 interacting protein and its role in regulating ACSL4 degradation", JOURNAL OF PROTEOMICS, ELSEVIER, AMSTERDAM, NL, vol. 229, 29 July 2020 (2020-07-29), AMSTERDAM, NL , XP086286607, ISSN: 1874-3919, DOI: 10.1016/j.jprot.2020.103926

Attorney, Agent or Firm:

ARCO PATENT & TRADEMARK ATTORNEYS (JP)

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