Title:
MUTANT TRANSGLUTAMINASE
Document Type and Number:
WIPO Patent Application WO/2021/177392
Kind Code:
A1
Abstract:
Provided is a mutant transglutaminase (mutant TG) having low acid resistance. This mutant TG has mutation at an amino acid residue such as A261, V271, A322, V326, D46, M16, Y34, W38, and S199.
Inventors:
KOBAYASHI HIROAKI (JP)
KOENUMA KEIKO (JP)
NOZAKI HIROYUKI (JP)
YOKOYAMA NORIKO (JP)
ONO TAKUTO (JP)
KOENUMA KEIKO (JP)
NOZAKI HIROYUKI (JP)
YOKOYAMA NORIKO (JP)
ONO TAKUTO (JP)
Application Number:
PCT/JP2021/008341
Publication Date:
September 10, 2021
Filing Date:
March 04, 2021
Export Citation:
Assignee:
AJINOMOTO KK (JP)
International Classes:
A23C9/127; A23C19/04; A23L5/00; C12N1/19; C12N1/21; C12N9/10; C12N15/54
Domestic Patent References:
| WO2008099898A1 | 2008-08-21 | |||
| WO2019107288A1 | 2019-06-06 | |||
| WO2010101256A1 | 2010-09-10 | |||
| WO2019107288A1 | 2019-06-06 | |||
| WO2010101256A1 | 2010-09-10 | |||
| WO2008099898A1 | 2008-08-21 | |||
| WO2013118544A1 | 2013-08-15 | |||
| WO2018079684A1 | 2018-05-03 | |||
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SOEDA, TAKAHIRO: "Quality improvement of milk products by transglutaminase", FOOD INDUSTRY, vol. 39, no. 17, 1996, JP , pages 65 - 70, XP009539652, ISSN: 0559-8990
LORAND,L. ET AL., ANAL. BIOCHEM., vol. 44, 1971, pages 221 - 213
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ELIZABETH C. TYLER ET AL., COMPUTERS AND BIOMEDICAL RESEARCH, vol. 24, no. 1, 1991, pages 72 - 96
BARTON GJ ET AL., JOURNAL OF MOLECULAR BIOLOGY, vol. 198, no. 2, 1987, pages 327 - 37
BACKMANN B.J.: "Escherichia coli and Salmonella Cellular and Molecular Biology", 1996, AMERICAN SOCIETY FOR MICROBIOLOGY PRESS, article "Derivations and Genotypes of some mutant derivatives of Escherichia coli K-12", pages: 2460 - 2488
INT. J. SYST. EVOL. MICROBIOL, vol. 66, 2016, pages 5575 - 5599
INT. J. SYST. BACTERIOL., vol. 41, 1991, pages 255
INT. J. SYST. EVOL. MICROBIOL., vol. 60, 2010, pages 874 - 879
PLASMID, vol. 12, 1984, pages 1 - 9
HIGUCHI, R.: "PCR Technology", vol. 61, 1989, STOCKTON PRESS
CARTER P., METH., IN ENZYMOL., vol. 154, 1987, pages 382
KRAMER, W.FRITS, H.J., METH. IN ENZYMOL., vol. 154, 1987, pages 367
APPL. MICROBIOL. BIOTECHNOL., vol. 53, 2000, pages 674 - 679
JOURNAL OF BIOTECHNOLOGY, vol. 104, 2003, pages 311 - 323
APPL. ENVIRON. MICROBIOL., vol. 71, no. 12, December 2005 (2005-12-01), pages 8587 - 96
GOLDSTEIN ET AL., PROKARYOTIC PROMOTERS IN BIOTECHNOLOGY, BIOTECHNOL. ANNU. REV., vol. 1, 1995, pages 105 - 128
AGRIC. BIOL. CHEM., vol. 48, 1984, pages 2901 - 2903
"Genetic Engineering", vol. 8, 1987, KYORITSU SHUPPAN CO., LTD, article "Fundamental Microbiology"
MILLER, J.H.: "Experiments in Molecular Genetics", 1972, COLD SPRING HARBOR LABORATORY
DATSENKO, K.A.WANNER, B.L., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 6640 - 6645
MANDEL, M.HIGA, A., J. MOL. BIOL., vol. 53, 1970, pages 159 - 162
DUNCAN, C.H.WILSON, G.A.YOUNG, F.E., GENE, vol. 1, 1977, pages 153 - 167
CHANG, S.CHOEN, S.N., MOL. GEN. GENET., vol. 168, 1979, pages 111 - 115
BIBB, M.J.WARD, J.M.HOPWOOD, O.A., NATURE, vol. 274, 1978, pages 398 - 400
HINNEN, A.HICKS, J.B.FINK, G.R., PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 1929 - 1933
See also references of EP 4115740A4
MU DONGDONG, LU JIAOJIAO, SHU CHANG, LI HAOWEN, LI XINGJIANG, CAI JING, LUO SHUIZHONG, YANG PEIZHOU, JIANG SHAOTONG, ZHENG ZHI: "Improvement of the activity and thermostability of microbial transglutaminase by multiple-site mutagenesis", BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, vol. 82, no. 1, 2 January 2018 (2018-01-02), pages 106 - 109, XP055852155
SOEDA, TAKAHIRO: "Quality improvement of milk products by transglutaminase", FOOD INDUSTRY, vol. 39, no. 17, 1996, JP , pages 65 - 70, XP009539652, ISSN: 0559-8990
LORAND,L. ET AL., ANAL. BIOCHEM., vol. 44, 1971, pages 221 - 213
TAKAGI,J. ET AL., ANAL. BIOCHEM., vol. 153, 1986, pages 296 - 298
APPL. ENVIRON. MICROBIOL., vol. 69, no. 1, 2003, pages 358 - 366
ELIZABETH C. TYLER ET AL., COMPUTERS AND BIOMEDICAL RESEARCH, vol. 24, no. 1, 1991, pages 72 - 96
BARTON GJ ET AL., JOURNAL OF MOLECULAR BIOLOGY, vol. 198, no. 2, 1987, pages 327 - 37
BACKMANN B.J.: "Escherichia coli and Salmonella Cellular and Molecular Biology", 1996, AMERICAN SOCIETY FOR MICROBIOLOGY PRESS, article "Derivations and Genotypes of some mutant derivatives of Escherichia coli K-12", pages: 2460 - 2488
INT. J. SYST. EVOL. MICROBIOL, vol. 66, 2016, pages 5575 - 5599
INT. J. SYST. BACTERIOL., vol. 41, 1991, pages 255
INT. J. SYST. EVOL. MICROBIOL., vol. 60, 2010, pages 874 - 879
PLASMID, vol. 12, 1984, pages 1 - 9
HIGUCHI, R.: "PCR Technology", vol. 61, 1989, STOCKTON PRESS
CARTER P., METH., IN ENZYMOL., vol. 154, 1987, pages 382
KRAMER, W.FRITS, H.J., METH. IN ENZYMOL., vol. 154, 1987, pages 367
APPL. MICROBIOL. BIOTECHNOL., vol. 53, 2000, pages 674 - 679
JOURNAL OF BIOTECHNOLOGY, vol. 104, 2003, pages 311 - 323
APPL. ENVIRON. MICROBIOL., vol. 71, no. 12, December 2005 (2005-12-01), pages 8587 - 96
GOLDSTEIN ET AL., PROKARYOTIC PROMOTERS IN BIOTECHNOLOGY, BIOTECHNOL. ANNU. REV., vol. 1, 1995, pages 105 - 128
AGRIC. BIOL. CHEM., vol. 48, 1984, pages 2901 - 2903
"Genetic Engineering", vol. 8, 1987, KYORITSU SHUPPAN CO., LTD, article "Fundamental Microbiology"
MILLER, J.H.: "Experiments in Molecular Genetics", 1972, COLD SPRING HARBOR LABORATORY
DATSENKO, K.A.WANNER, B.L., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 6640 - 6645
MANDEL, M.HIGA, A., J. MOL. BIOL., vol. 53, 1970, pages 159 - 162
DUNCAN, C.H.WILSON, G.A.YOUNG, F.E., GENE, vol. 1, 1977, pages 153 - 167
CHANG, S.CHOEN, S.N., MOL. GEN. GENET., vol. 168, 1979, pages 111 - 115
BIBB, M.J.WARD, J.M.HOPWOOD, O.A., NATURE, vol. 274, 1978, pages 398 - 400
HINNEN, A.HICKS, J.B.FINK, G.R., PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 1929 - 1933
See also references of EP 4115740A4
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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