Title:
N-ACYL HYDRAZINE DERIVATIVES, METHOD FOR PRODUCING N-ACYL HYDRAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, USES THEREOF AND METHODS FOR TREATMENT
Document Type and Number:
WIPO Patent Application WO/2010/043010
Kind Code:
A1
Abstract:
The present invention relates to N-acyl hydrazine compounds capable of promoting vascular smooth muscle relaxation by activation of the biosynthesis of nitric oxide (NO) and having the general formula (I), and to the method for producing same, to pharmaceutical compositions containing same, to uses thereof and methods for treatment of dysfunctions related to NO synthesis in human and non-human mammals, and to the treatment of muscle disorders.
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Inventors:
FRAGA CARLOS ALBERTO MANSSOUR (BR)
BARREIRO ELIEZER JESUS DE LACERDA (BR)
SUDO ROBERTO TAKASHI (BR)
BEIRAI HALLEN JANNISY VIEIRA (BR)
KUEMMERIE ARTHR EUGEN (BR)
BARREIRO ELIEZER JESUS DE LACERDA (BR)
SUDO ROBERTO TAKASHI (BR)
BEIRAI HALLEN JANNISY VIEIRA (BR)
KUEMMERIE ARTHR EUGEN (BR)
Application Number:
PCT/BR2009/000320
Publication Date:
April 22, 2010
Filing Date:
October 15, 2009
Export Citation:
Assignee:
UNIV RIO DE JANEIRO (BR)
FRAGA CARLOS ALBERTO MANSSOUR (BR)
BARREIRO ELIEZER JESUS DE LACE (BR)
SUDO ROBERTO TAKASHI (BR)
BEIRAI HALLEN JANNISY VIEIRA (BR)
KUEMMERIE ARTHR EUGEN (BR)
FRAGA CARLOS ALBERTO MANSSOUR (BR)
BARREIRO ELIEZER JESUS DE LACE (BR)
SUDO ROBERTO TAKASHI (BR)
BEIRAI HALLEN JANNISY VIEIRA (BR)
KUEMMERIE ARTHR EUGEN (BR)
International Classes:
C07D409/12; A61K31/381; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P21/02
Foreign References:
| US7091238B1 | 2006-08-15 | |||
| BRPI0403363A | 2006-05-02 |
Other References:
SILVA, A.G. ET AL.: "Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues.", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, 2005, pages 3431 - 3437
Attorney, Agent or Firm:
DE CASTRO, Joubert, Gonçalves (IcaraíNiterói - RJ, Cep: -003, BR)
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