Title:
NANOSTRUCTURED DEVICES FOR SEPARATION AND ANALYSIS
Document Type and Number:
WIPO Patent Application WO2002065515
Kind Code:
A3
Abstract:
The present invention provides a matrix comprising an array of nanostructures that exhibit a variation (gradient) in physical properties (such as size or pitch) in at least one direction of the plane containing said array. A method for forming an array having a gradient property is also provided. In addition, a separation method is provided comprising the steps of: providing a matrix comprising an array of nanostructures arranged so that the array has the property of a gradient; and conducting at least one biomolecule separation process to separate biomolecules in a composition containing a plurality of biomolecules using the matrix.
Inventors:
LOPEZ GABRIEL P (US)
BRUECK STEVEN R J (US)
ISTA LINNEA K (US)
O'BRIEN MICHAEL J (US)
HERSEE STEPHEN D (US)
BRUECK STEVEN R J (US)
ISTA LINNEA K (US)
O'BRIEN MICHAEL J (US)
HERSEE STEPHEN D (US)
Application Number:
PCT/US2002/004381
Publication Date:
March 06, 2003
Filing Date:
February 14, 2002
Export Citation:
Assignee:
STC UNM (US)
LOPEZ GABRIEL P (US)
BRUECK STEVEN R J (US)
ISTA LINNEA K (US)
O'BRIEN MICHAEL J (US)
HERSEE STEPHEN D (US)
LOPEZ GABRIEL P (US)
BRUECK STEVEN R J (US)
ISTA LINNEA K (US)
O'BRIEN MICHAEL J (US)
HERSEE STEPHEN D (US)
International Classes:
B01D15/08; B01D57/00; B01L3/00; B81B1/00; C12Q1/00; G01N27/447; G01N30/60; H01L21/00; G01N30/02; G01N30/52; (IPC1-7): G01N27/447
Domestic Patent References:
| WO2000042233A1 | 2000-07-20 |
Foreign References:
| US5867266A | 1999-02-02 | |||
| EP0977030A1 | 2000-02-02 |
Other References:
J. HAN AND H. G. CRAIGHEAD: "Entropic trapping and sieving of long DNA molecules in a nanofluidic channel", J.VAC.SCI.TECHNOL. A, vol. 17, no. 4, July 1999 (1999-07-01) - August 1999 (1999-08-01), pages 2142 - 2147, XP002223274
YANG XIAO M ET AL: "Guided self-assembly of symmetric diblock copolymer films on chemically nanopatterned substrates", MACROMOLECULES;MACROMOLECULES DEC 2000 ACS, WASHINGTON, DC, USA, vol. 33, no. 26, December 2000 (2000-12-01), pages 9575 - 9582, XP002223275
PARK, HARRISON, CHAIKIN, REGISTER, ADAMSON: "Block Copolymer Lithography: Periodic Arrays of about 10 to the 11th Holes in 1 Square Centimeter", SCIENCE, vol. 276, 30 May 1997 (1997-05-30), pages 1401 - 1404, XP002223276
T. A. J. DUKE AND R. H. AUSTIN: "Microfabricated Sieve for the Continuous Sorting of Macromolecules"", PHYSICAL REVIEW LETTERS, vol. 80, no. 7, 16 February 1998 (1998-02-16), pages 1552 - 1555, XP002223277
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; January 2001 (2001-01-01), CHEN YONG ET AL: "Nanofabrication: Conventional and nonconventional methods.", XP002223278, Database accession no. PREV200100180069
YANG XIAO M ET AL: "Guided self-assembly of symmetric diblock copolymer films on chemically nanopatterned substrates", MACROMOLECULES;MACROMOLECULES DEC 2000 ACS, WASHINGTON, DC, USA, vol. 33, no. 26, December 2000 (2000-12-01), pages 9575 - 9582, XP002223275
PARK, HARRISON, CHAIKIN, REGISTER, ADAMSON: "Block Copolymer Lithography: Periodic Arrays of about 10 to the 11th Holes in 1 Square Centimeter", SCIENCE, vol. 276, 30 May 1997 (1997-05-30), pages 1401 - 1404, XP002223276
T. A. J. DUKE AND R. H. AUSTIN: "Microfabricated Sieve for the Continuous Sorting of Macromolecules"", PHYSICAL REVIEW LETTERS, vol. 80, no. 7, 16 February 1998 (1998-02-16), pages 1552 - 1555, XP002223277
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; January 2001 (2001-01-01), CHEN YONG ET AL: "Nanofabrication: Conventional and nonconventional methods.", XP002223278, Database accession no. PREV200100180069
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