Title:
NEISSERIA GONORRHOEAE DETECTION KIT AND NEISSERIA GONORRHOEAE DETECTION METHOD
Document Type and Number:
WIPO Patent Application WO/2022/210594
Kind Code:
A1
Abstract:
Provided is a kit for detecting Neisseria gonorrhoeae in a specimen, as a novel Neisseria gonorrhoeae detection means that has superior Neisseria gonorrhoeae detection sensitivity and can detect Neisseria gonorrhoeae in situ from a variety of specimens, such as urine or intraoral fluid. This kit includes a capture antibody that is for capturing a Neisseria gonorrhoeae-originating antigen in a specimen, and a detection antibody that has a detection marker and is for marking the Neisseria gonorrhoeae-originating antigen in the specimen. The Neisseria gonorrhoeae-originating antigen is a Neisseria gonorrhoeae ribosomal protein L7/L12. One of the capture antibody and the detection antibody is a first monoclonal antibody or a fragment or derivative thereof that produces an antigen-antibody reaction with an epitope including one or more amino acid residues selected from the second to 14th amino acid residues from the N-terminus in the Neisseria gonorrhoeae L7/L12 amino acid sequence indicated in SEQ ID NO: 1. The other of the capture antibody and the detection antibody is a second monoclonal antibody or a fragment or derivative thereof that produces an antigen-antibody reaction with an epitope including one or more amino acid residues selected from the 102nd to 123rd amino acid residues from the N-terminus in the Neisseria gonorrhoeae L7/L12 amino acid sequence indicated in SEQ ID NO: 1.
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Inventors:
ODA KOTARO (JP)
SUGATA MIKA (JP)
SUGATA MIKA (JP)
Application Number:
PCT/JP2022/015166
Publication Date:
October 06, 2022
Filing Date:
March 28, 2022
Export Citation:
Assignee:
ASAHI CHEMICAL IND (JP)
International Classes:
C07K16/12; G01N33/53; G01N33/543; G01N33/569
Domestic Patent References:
| WO2000006603A1 | 2000-02-10 | |||
| WO2000006603A1 | 2000-02-10 | |||
| WO2001057089A1 | 2001-08-09 |
Foreign References:
| JP2001011096A | 2001-01-16 | |||
| JP2017133951A | 2017-08-03 | |||
| JPH10500310A | 1998-01-13 | |||
| JP2013188181A | 2013-09-26 |
Other References:
ISBEY ET AL., GENITOURINARY MEDICINE, vol. 73, no. 5, 1997, pages 378 - 382
PACKAGE INSERTS OF ABBOTT CLEARVIEWTM GONOREA
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, no. 3, 1990, pages 403 - 10
KABAT ET AL., THE JOURNAL OF IMMUNOLOGY, vol. 147, no. 5, 1991, pages 1709 - 1719
AL LAZIKANI ET AL., JOURNAL OF MOLECULAR BIOLOGY, vol. 273, no. 4, 1997, pages 927 - 948
SHAMBROOK, J: "Molecular Cloning, A laboratory manual", COLD SPRING HARBOR LABORATORY PRESS
PACKAGE INSERTS OF ABBOTT CLEARVIEWTM GONOREA
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, no. 3, 1990, pages 403 - 10
KABAT ET AL., THE JOURNAL OF IMMUNOLOGY, vol. 147, no. 5, 1991, pages 1709 - 1719
AL LAZIKANI ET AL., JOURNAL OF MOLECULAR BIOLOGY, vol. 273, no. 4, 1997, pages 927 - 948
SHAMBROOK, J: "Molecular Cloning, A laboratory manual", COLD SPRING HARBOR LABORATORY PRESS
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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