NOVEL FUSIONS AND DETECTION METHOD THEREFOR

Title:

NOVEL FUSIONS AND DETECTION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2015/064620

Kind Code:

A1

Abstract:

　Provided are: a detection method in which fusions (fusion proteins and fusion genes that encode the fusion proteins), which are new causative agents of cancer, are elucidated, and new fusions and derivatives are detected on the basis of the results; a kit and primer set for the aforementioned detection method; a method for screening inhibitors of the expression and/or activity of polypeptides which are the fusion proteins; and pharmaceutical compositions, which contain the aforementioned inhibitors, for treating cancer.　The fusion proteins comprise ZSCAB9 fusion proteins or ALK fusion proteins. In the screening method, the fusion proteins or fusion genes that encode the fusion proteins are detected in a sample obtained from a subject.

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Inventors:

TAKEUCHI KENGO (JP)
TOGASHI YUKI (JP)
SAKATA SEIJI (JP)
FUJITA NAOYA (JP)
KATAYAMA RYOHEI (JP)

Application Number:

PCT/JP2014/078728

Publication Date:

May 07, 2015

Filing Date:

October 29, 2014

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Assignee:

JAPAN FOUND CANCER (JP)

International Classes:

C12N15/09; A61K45/00; A61P1/00; A61P35/00; A61P43/00; C07K14/435; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12Q1/68; G01N33/15; G01N33/50; G01N33/574

Domestic Patent References:

WO2011043220A1

2011-04-14

Foreign References:

JP2009100783A

2009-05-14

Other References:

KENGO TAKEUCHI ET AL.: "Multiplex Reverse Transcription-PCR Screening for EML4-ALK Fusion Transcripts", CLINICAL CANCER RESEARCH, vol. 14, no. 20, 2008, pages 6618 - 6624, XP055052558, DOI: doi:10.1158/1078-0432.CCR-08-1018
KENGO TAKEUCHI ET AL.: "KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer", CLINICAL CANCER RESEARCH, vol. 15, no. 9, 2009, pages 3143 - 3149, XP055069999, DOI: doi:10.1158/1078-0432.CCR-08-3248
RUTH H. PALMER ET AL.: "Anaplastic lymphoma kinase: signalling in development and disease", BIOCHEMICAL JOURNAL, vol. 420, 2009, pages 345 - 361
PAULINE L. LEE ET AL.: "Three Genes Encoding Zinc Finger Proteins on Human Chromosome 6p21.3: Members of a New Subclass of the Kruppel Gene Family Containing the Conserved SCAN Box Domain", GENOMICS, vol. 43, 1997, pages 191 - 201, XP004459255, DOI: doi:10.1006/geno.1997.4806

Attorney, Agent or Firm:

MORITA Kenichi et al. (JP)
Ken-ichi Morita (JP)

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