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Title:
ONCOLYTIC VIRUS
Document Type and Number:
WIPO Patent Application WO2002050304
Kind Code:
A3
Abstract:
Methods of reducing the viability of a tumor cell, infecting a neoplasm in a mammal with a virus, or treating a neoplasm in a mammal, utilizing certain non-naturally occuring viruses are disclosed. Viral reassortants, for example reovirus reassortants, and techniques for identifying PKR-sensitive viruses are also disclosed.

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Inventors:
BROWN EARL GARNET (CA)
BELL JOHN CAMERON (CA)
Application Number:
PCT/US2001/045108
Publication Date:
November 28, 2002
Filing Date:
December 03, 2001
Export Citation:
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Assignee:
PRO VIRUS INC (US)
BROWN EARL GARNET (CA)
BELL JOHN CAMERON (CA)
International Classes:
C12N15/09; A61K35/76; A61K35/765; A61P35/00; C12N7/00; A61K38/00; (IPC1-7): C12Q1/04; A61K35/76; A61P35/00
Domestic Patent References:
WO1999008692A11999-02-25
WO2000050051A22000-08-31
Other References:
STRONG J E ET AL: "The molecular basis of viral oncolysis: usurpation of the Ras signalling pathway by reovirus", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 17, no. 12, 1998, pages 3351 - 3362, XP002189893, ISSN: 0261-4189
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