Title:
PACAP STABILIZED PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2019/098254
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a PACAP peptide having increased stability. The problem is solved by the discovery that substituting a carboxy group of the position 3 and/or position 8 aspartic acid in the PACAP sequence by tetrazole significantly enhances stability.
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Inventors:
MACHIDA SHINNOSUKE (JP)
NAKAJIMA TAKESHI (JP)
NAKAJIMA TAKESHI (JP)
Application Number:
PCT/JP2018/042196
Publication Date:
May 23, 2019
Filing Date:
November 14, 2018
Export Citation:
Assignee:
SENJU PHARMA CO (JP)
International Classes:
C07K14/47; A61K38/22; A61P25/00; A61P27/02; A61P27/04; A61P29/00; A61P43/00; C12N15/12
Domestic Patent References:
WO2005102375A1 | 2005-11-03 | |||
WO2017027848A1 | 2017-02-16 |
Foreign References:
JPH10505863A | 1998-06-09 | |||
JP2013509450A | 2013-03-14 | |||
JPH09110729A | 1997-04-28 | |||
JP2004256547A | 2004-09-16 | |||
JPH07228581A | 1995-08-29 | |||
JP2009269818A | 2009-11-19 | |||
JP2014510101A | 2014-04-24 | |||
JP2012232952A | 2012-11-29 | |||
JP2009269818A | 2009-11-19 |
Other References:
S. BOURGAULT, CURRENT MEDICINAL CHEMISTRY, vol. 16, 2009, pages 4462 - 4480
LOUISE DICKSON, PHARMACOLOGY & THERAPEUTICS, vol. 12, 2009, pages 294 - 316
LOUISE DICKSON, PHARMACOLOGY & THERAPEUTICS, vol. 12, 2009, pages 294 - 316
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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