PEPTIDE IMAGING AGENTS - GE HEALTHCARE LTD

Title:

PEPTIDE IMAGING AGENTS

Document Type and Number:

WIPO Patent Application WO/2009/016180

Kind Code:

A3

Abstract:

The present invention relates to labelled cMet binding peptides suitable for optical imaging in vivo. The peptides are labelled with a benzopyrylium dye suitable for imaging in the red to near-infrared region. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods, especially of use in the detection, staging, diagnosis, monitoring of disease progression or monitoring of treatment of colorectal cancer (CRC).

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Inventors:

NAIRNE ROBERT JAMES DOMETT (GB)
HEALEY ANDREW JOHN (NO)
JOHANNESEN EDVIN WILHELM (NO)

Application Number:

PCT/EP2008/059941

Publication Date:

February 04, 2010

Filing Date:

July 29, 2008

Export Citation:

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Assignee:

GE HEALTHCARE LTD (GB)
NAIRNE ROBERT JAMES DOMETT (GB)
HEALEY ANDREW JOHN (NO)
JOHANNESEN EDVIN WILHELM (NO)

International Classes:

C09B23/02; A61K47/48; A61K49/00; C09B23/06; C09B23/08; C12Q1/68; G01N33/58

Domestic Patent References:

WO2004078778A2	2004-09-16
WO2005030266A2	2005-04-07
WO2001090253A1	2001-11-29
WO2008015415A2	2008-02-07
WO2008139207A2	2008-11-20
WO2009026177A1	2009-02-26

Foreign References:

EP1674478A1	2006-06-28
US20040162423A1	2004-08-19
US20040110161A1	2004-06-10

Other References:

M.-R. LISY, E. SCHÜLER, F. LEHMANN, P. CZERNEY, W. A. KAISER, I. HILGER: "Diagnosis of peritonitis using near-infrared optical imaging of in vivo labeled monocytes-macrophages", JOURNAL OF BIOMEDICAL OPTICS, vol. 11, no. 6, 2 January 2007 (2007-01-02), pages 064014-1 - 064014-9, XP002548665

Attorney, Agent or Firm:

CANNING, Lewis, Reuben (Amersham PlaceLittle Chalfont, Buckinghamshire HP7 9NA, GB)

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