Title:
PHARMACEUTICAL COMPOSITION, ADSORPTION METHOD, TREATMENT METHOD AND PREVENTION METHOD
Document Type and Number:
WIPO Patent Application WO/2023/204278
Kind Code:
A1
Abstract:
One purpose of the present disclosure is to provide a novel pharmaceutical composition, and preferably, to provide a pharmaceutical composition which makes it possible to adsorb various disease-causing substances inside an organism. A pharmaceutical composition which comprises two-dimensional particles having one or more layers which include a layer body represented by the formula MmXn (in the formula, M is at least one type of metal belonging to group 3, 4, 5, 6, or 7, X is a carbon atom, a nitrogen atom, or a combination thereof, n is 1-4, inclusive, and m is greater than n and at most 5), and a modification or terminal T (T is at least one group or atom selected from the group consisting of a hydroxyl group, a fluorine atom, a chlorine atom, an oxygen atom, and a hydrogen atom) present on the surface of the layer body, said pharmaceutical composition being configured so as to be administered orally and as a result, adsorb disease-causing substances inside the organism.
Inventors:
KIMURA YUKI (JP)
KOBAYASHI YUSUKE (JP)
WAKUI HIROMICHI (JP)
AZUSHIMA KENGO (JP)
TAMURA KOUICHI (JP)
TAKASE HAJIME (JP)
KOBAYASHI YUSUKE (JP)
WAKUI HIROMICHI (JP)
AZUSHIMA KENGO (JP)
TAMURA KOUICHI (JP)
TAKASE HAJIME (JP)
Application Number:
PCT/JP2023/015821
Publication Date:
October 26, 2023
Filing Date:
April 20, 2023
Export Citation:
Assignee:
MURATA MANUFACTURING CO (JP)
International Classes:
A61K33/00; A61K9/14; A61M1/16; A61M1/36; A61P7/00; A61P13/12; A61P39/02; B01D15/00; B01D69/10; B01D69/12; B01D71/02; B01J20/02; B01J20/20; B01J20/30
Foreign References:
| CN115531411A | 2022-12-30 |
Other References:
ZHAO QI, SEREDYCH MYKOLA, PRECETTI ELIOT, SHUCK CHRISTOPHER E., HARHAY MEERA, PANG RUI, SHAN CHONG-XIN, GOGOTSI YURY: "Adsorption of Uremic Toxins Using Ti 3 C 2 T x MXene for Dialysate Regeneration", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 14, no. 9, 22 September 2020 (2020-09-22), US , pages 11787 - 11798, XP093100634, ISSN: 1936-0851, DOI: 10.1021/acsnano.0c04546
OZULUMBA TOCHUKWU, INGAVLE GANESH, GOGOTSI YURY, SANDEMAN SUSAN: "Moderating cellular inflammation using 2-dimensional titanium carbide MXene and graphene variants", BIOMATERIALS SCIENCE, R S C PUBLICATIONS, GB, vol. 9, no. 5, 10 March 2021 (2021-03-10), GB , pages 1805 - 1815, XP093100637, ISSN: 2047-4830, DOI: 10.1039/D0BM01953D
WANG TIANYI, SUN XIAOYU, GUO XIN, ZHANG JINQIANG, YANG JIAN, TAO SHOUXUAN, GUAN JUN, ZHOU LIN, HAN JIE, WANG CHENGYIN, YAO HANG, W: "Ultraefficiently Calming Cytokine Storm Using Ti 3 C 2 T x MXene", SMALL METHODS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 5, no. 5, 1 May 2021 (2021-05-01), DE , pages 2001108, XP093100642, ISSN: 2366-9608, DOI: 10.1002/smtd.202001108
SUGURU YAMAMOTO: "Molecular mechanisms underlying uremic toxin-induced diseases in chronic kidney diseaseand therapeutic interventions", vol. 58, no. 8, 1 January 2016 (2016-01-01), pages 1250 - 1254, XP009549653
F. DURANTON, G. COHEN, R. DE SMET, M. RODRIGUEZ, J. JANKOWSKI, R. VANHOLDER, A. ARGILES: "Normal and Pathologic Concentrations of Uremic Toxins", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 23, no. 7, 1 July 2012 (2012-07-01), pages 1258 - 1270, XP055176137, ISSN: 10466673, DOI: 10.1681/ASN.2011121175
SHARMA GEETU, MUTHUSWAMY ELAYARAJA, NAGUIB MICHAEL, GOGOTSI YURY, NAVROTSKY ALEXANDRA, WU DI: "Calorimetric Study of Alkali Metal Ion (K + , Na + , Li + ) Exchange in a Clay-Like MXene", THE JOURNAL OF PHYSICAL CHEMISTRY C, AMERICAN CHEMICAL SOCIETY, US, vol. 121, no. 28, 20 July 2017 (2017-07-20), US , pages 15145 - 15153, XP093100680, ISSN: 1932-7447, DOI: 10.1021/acs.jpcc.7b02419
ZHAO XING, WANG LI‐YA, LI JIA‐MENG, PENG LI‐MEI, TANG CHUN‐YAN, ZHA XIANG‐JUN, KE KAI, YANG MING‐BO, SU BAI‐HAI, YANG WEI: "Redox‐Mediated Artificial Non‐Enzymatic Antioxidant MXene Nanoplatforms for Acute Kidney Injury Alleviation", ADVANCED SCIENCE, vol. 8, no. 18, 1 September 2021 (2021-09-01), pages 2101498, XP093100686, ISSN: 2198-3844, DOI: 10.1002/advs.202101498
PIENIAZEK ANNA, BERNASINSKA-SLOMCZEWSKA JOANNA, GWOZDZINSKI LUKASZ: "Uremic Toxins and Their Relation with Oxidative Stress Induced in Patients with CKD", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, no. 12, 8 June 2021 (2021-06-08), pages 6196, XP093100687, DOI: 10.3390/ijms22126196
XIONG WENFANG; WU YIZHANG; SUN KUO-YANG; WU X.S.; ZHOU YI-HUA; CAI HONG-LING; ZOU XIAOPING: "Ultrathin niobium carbide alleviates colitis through absorbing ROS", MATERIALS & DESIGN, ELSEVIER, AMSTERDAM, NL, vol. 213, 23 December 2021 (2021-12-23), AMSTERDAM, NL , XP086935602, ISSN: 0264-1275, DOI: 10.1016/j.matdes.2021.110351
HOU LINQIAN, GONG FEI, LIU BO, YANG XIAOYUAN, CHEN LINFU, LI GUANGQIANG, GONG YUEHAN, LIANG CHAO, YANG NAILIN, SHEN XIAN, LIU ZHUA: "Orally administered titanium carbide nanosheets as anti-inflammatory therapy for colitis", THERANOSTICS, IVYSPRING INTERNATIONAL PUBLISHER, AU, vol. 12, no. 8, 1 January 2022 (2022-01-01), AU , pages 3834 - 3846, XP093100691, ISSN: 1838-7640, DOI: 10.7150/thno.70668
OZULUMBA TOCHUKWU, INGAVLE GANESH, GOGOTSI YURY, SANDEMAN SUSAN: "Moderating cellular inflammation using 2-dimensional titanium carbide MXene and graphene variants", BIOMATERIALS SCIENCE, R S C PUBLICATIONS, GB, vol. 9, no. 5, 10 March 2021 (2021-03-10), GB , pages 1805 - 1815, XP093100637, ISSN: 2047-4830, DOI: 10.1039/D0BM01953D
WANG TIANYI, SUN XIAOYU, GUO XIN, ZHANG JINQIANG, YANG JIAN, TAO SHOUXUAN, GUAN JUN, ZHOU LIN, HAN JIE, WANG CHENGYIN, YAO HANG, W: "Ultraefficiently Calming Cytokine Storm Using Ti 3 C 2 T x MXene", SMALL METHODS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 5, no. 5, 1 May 2021 (2021-05-01), DE , pages 2001108, XP093100642, ISSN: 2366-9608, DOI: 10.1002/smtd.202001108
SUGURU YAMAMOTO: "Molecular mechanisms underlying uremic toxin-induced diseases in chronic kidney diseaseand therapeutic interventions", vol. 58, no. 8, 1 January 2016 (2016-01-01), pages 1250 - 1254, XP009549653
F. DURANTON, G. COHEN, R. DE SMET, M. RODRIGUEZ, J. JANKOWSKI, R. VANHOLDER, A. ARGILES: "Normal and Pathologic Concentrations of Uremic Toxins", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 23, no. 7, 1 July 2012 (2012-07-01), pages 1258 - 1270, XP055176137, ISSN: 10466673, DOI: 10.1681/ASN.2011121175
SHARMA GEETU, MUTHUSWAMY ELAYARAJA, NAGUIB MICHAEL, GOGOTSI YURY, NAVROTSKY ALEXANDRA, WU DI: "Calorimetric Study of Alkali Metal Ion (K + , Na + , Li + ) Exchange in a Clay-Like MXene", THE JOURNAL OF PHYSICAL CHEMISTRY C, AMERICAN CHEMICAL SOCIETY, US, vol. 121, no. 28, 20 July 2017 (2017-07-20), US , pages 15145 - 15153, XP093100680, ISSN: 1932-7447, DOI: 10.1021/acs.jpcc.7b02419
ZHAO XING, WANG LI‐YA, LI JIA‐MENG, PENG LI‐MEI, TANG CHUN‐YAN, ZHA XIANG‐JUN, KE KAI, YANG MING‐BO, SU BAI‐HAI, YANG WEI: "Redox‐Mediated Artificial Non‐Enzymatic Antioxidant MXene Nanoplatforms for Acute Kidney Injury Alleviation", ADVANCED SCIENCE, vol. 8, no. 18, 1 September 2021 (2021-09-01), pages 2101498, XP093100686, ISSN: 2198-3844, DOI: 10.1002/advs.202101498
PIENIAZEK ANNA, BERNASINSKA-SLOMCZEWSKA JOANNA, GWOZDZINSKI LUKASZ: "Uremic Toxins and Their Relation with Oxidative Stress Induced in Patients with CKD", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, no. 12, 8 June 2021 (2021-06-08), pages 6196, XP093100687, DOI: 10.3390/ijms22126196
XIONG WENFANG; WU YIZHANG; SUN KUO-YANG; WU X.S.; ZHOU YI-HUA; CAI HONG-LING; ZOU XIAOPING: "Ultrathin niobium carbide alleviates colitis through absorbing ROS", MATERIALS & DESIGN, ELSEVIER, AMSTERDAM, NL, vol. 213, 23 December 2021 (2021-12-23), AMSTERDAM, NL , XP086935602, ISSN: 0264-1275, DOI: 10.1016/j.matdes.2021.110351
HOU LINQIAN, GONG FEI, LIU BO, YANG XIAOYUAN, CHEN LINFU, LI GUANGQIANG, GONG YUEHAN, LIANG CHAO, YANG NAILIN, SHEN XIAN, LIU ZHUA: "Orally administered titanium carbide nanosheets as anti-inflammatory therapy for colitis", THERANOSTICS, IVYSPRING INTERNATIONAL PUBLISHER, AU, vol. 12, no. 8, 1 January 2022 (2022-01-01), AU , pages 3834 - 3846, XP093100691, ISSN: 1838-7640, DOI: 10.7150/thno.70668
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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