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Title:
PHARMACEUTICAL COMPOSITION FOR TREATING HYPERAMMONEMIA
Document Type and Number:
WIPO Patent Application WO/2020/209059
Kind Code:
A1
Abstract:
This disclosure provides a pharmaceutical composition for treating hyperammonemia that contains α-ketoglutaric acid or dimethyl-α-ketoglutaric acid, or a pharmaceutically acceptable salt thereof.

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Inventors:
YOSHINO MAKOTO (JP)
TAKAHASHI TOMOYUKI (JP)
FUKUI KAORI (JP)
ISHIHARA NAOTADA (JP)
NAGASHIMA HIROSHI (JP)
Application Number:
PCT/JP2020/013220
Publication Date:
October 15, 2020
Filing Date:
March 25, 2020
Export Citation:
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Assignee:
UNIV KURUME (JP)
UNIV MEIJI (JP)
International Classes:
A61P1/16; A61K31/194; A61K31/225; A61P3/00; A61P7/00; A61P13/02
Domestic Patent References:
WO2016083399A12016-06-02
Foreign References:
US3441650A1969-04-29
DE19929993A12001-01-11
Other References:
DAVULURI, G. ET AL.: "Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress", THE JOURNAL OF PHYSIOLOGY, vol. 594, no. 24, 2016, pages 7341 - 7360, XP055748357, ISSN: 1469-7793
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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