POLYMORPH OF KRAS INHIBITOR OR SALT THEREOF AND PREPARATION OF FORMULATION OF POLYMORPH

Title:

POLYMORPH OF KRAS INHIBITOR OR SALT THEREOF AND PREPARATION OF FORMULATION OF POLYMORPH

Document Type and Number:

WIPO Patent Application WO/2023/226630

Kind Code:

A1

Abstract:

Provided is a polymorph of a cycloalkyl and heterocycloalkyl inhibitor or a salt thereof. Specifically, the present invention relates to a polymorph of (S)-2-(4-(7-(8-chloro-7-fluoronaphthalen-1-yl)-2-(1-((dimethylamino)methyl)cyclopropyl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile, or a pharmaceutically acceptable salt thereof, or a solvate thereof, i.e., a polymorph of a compound as represented by formula I or a salt thereof, or a solvate thereof. The polymorph is suitable for preparing a pharmaceutical composition of KRAS inhibitor.

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Inventors:

LV BINHUA (CN)
FENG WEIDONG (CN)
CUI DAWEI (CN)
MA WENDI (CN)
WANG CAI (CN)
LIAN CHANGMING (CN)
YE WEI (CN)
ZHAO YANFU (CN)

Application Number:

PCT/CN2023/089031

Publication Date:

November 30, 2023

Filing Date:

April 18, 2023

Export Citation:

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Assignee:

SUZHOU ZELGEN BIOPHARMACEUTICALS CO LTD (CN)
SHANGHAI ZELGEN PHARMA TECH CO LTD (CN)

International Classes:

C07D471/04; A61K31/519; A61P35/00; C07D519/00

Foreign References:

CN112694475A	2021-04-23
CN113666923A	2021-11-19
CN112778301A	2021-05-11
CN113105448A	2021-07-13
CN113801113A	2021-12-17
US20140288045A1	2014-09-25

Attorney, Agent or Firm:

XU & PARTNERS, LLC. (CN)

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