Title:
PROCESS FOR PRODUCING AVERMECTIN DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2001/062939
Kind Code:
A1
Abstract:
22,23-Dihydroavermectin B1a, which is useful in drugs, veterinary drugs and pesticides, can be produced by direct fermentation. Thus, the troublesome and difficult industrial steps of purifying avermectin B1a and chemically modifying avermectin B1a involved in the conventional are can be omitted and therefore 22,23-dihydroavermectin B1a can be industrially produced while largely saving the cost and time. Moreover, a preparation containing 22,23-dihydroavermectin B1a alone, which is highly efficacious as a drug, can be produced.
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Inventors:
ENDO HIROFUMI (JP)
YAMAGUCHI HIROYUKI (JP)
KANDA YUTAKA (JP)
HASHIMOTO SHINICHI (JP)
OMURA SATOSHI (JP)
IKEDA HARUO (JP)
YAMAGUCHI HIROYUKI (JP)
KANDA YUTAKA (JP)
HASHIMOTO SHINICHI (JP)
OMURA SATOSHI (JP)
IKEDA HARUO (JP)
Application Number:
PCT/JP2001/001381
Publication Date:
August 30, 2001
Filing Date:
February 23, 2001
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
KITASATO INST (JP)
ENDO HIROFUMI (JP)
YAMAGUCHI HIROYUKI (JP)
KANDA YUTAKA (JP)
HASHIMOTO SHINICHI (JP)
OMURA SATOSHI (JP)
IKEDA HARUO (JP)
KITASATO INST (JP)
ENDO HIROFUMI (JP)
YAMAGUCHI HIROYUKI (JP)
KANDA YUTAKA (JP)
HASHIMOTO SHINICHI (JP)
OMURA SATOSHI (JP)
IKEDA HARUO (JP)
International Classes:
C07C327/30; C12N1/21; C12N15/52; C12N15/53; C12N15/54; (IPC1-7): C12N15/54; C12N15/53; C12N9/10; C12N9/14; C12N1/21; C07C327/30; C12P17/08
Domestic Patent References:
| WO2000050605A1 | 2000-08-31 |
Foreign References:
| EP0997528A1 | 2000-05-03 | |||
| JPH06189774A | 1994-07-12 | |||
| EP0391594A2 | 1990-10-10 |
Other References:
A.F.A. MARSDEN ET AL.: "Engineering broader specificity into an antibiotic-producing polyketide synthase", SCIENCE, vol. 279, no. 5348, 1998, pages 199 - 202, XP002941701
H. IKEDA ET AL.: "Avermectin biosynthesis", CHEM. REV., vol. 97, no. 7, 1997, pages 2591 - 2609, XP002941702
H. IKEDA ET AL.: "Strategic strain improvement of antibiotic producer", ACTINOMYCETOLOGICA, vol. 5, no. 2, 1991, pages 86 - 99, XP002941703
Y.S. TSANTRIZOS ET AL.: "Biosynthesis of the hypotensive metabolite oudenone by oudemansiella radicata. 1. Intact incorporation of a tetraketide chain elongation intermediate", J. ORG. CHEM., vol. 60, no. 21, 1995, pages 6922 - 6929, XP002941704
Y. LIU ET AL.: "Biosynthetic incorporation of advanced precursors into dehydrocurvularin, a polyketide phytotoxin from alternaria cinerariae", TETRAHEDRON, vol. 54, no. 52, 1998, pages 15937 - 15958, XP002941705
H. IKEDA ET AL.: "Avermectin biosynthesis", CHEM. REV., vol. 97, no. 7, 1997, pages 2591 - 2609, XP002941702
H. IKEDA ET AL.: "Strategic strain improvement of antibiotic producer", ACTINOMYCETOLOGICA, vol. 5, no. 2, 1991, pages 86 - 99, XP002941703
Y.S. TSANTRIZOS ET AL.: "Biosynthesis of the hypotensive metabolite oudenone by oudemansiella radicata. 1. Intact incorporation of a tetraketide chain elongation intermediate", J. ORG. CHEM., vol. 60, no. 21, 1995, pages 6922 - 6929, XP002941704
Y. LIU ET AL.: "Biosynthetic incorporation of advanced precursors into dehydrocurvularin, a polyketide phytotoxin from alternaria cinerariae", TETRAHEDRON, vol. 54, no. 52, 1998, pages 15937 - 15958, XP002941705
Attorney, Agent or Firm:
Hiraki, Yusuke (17-1 Toranomon 1-chome Minato-ku, Tokyo, JP)
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