Title:
PROCESS FOR THE SYNTHESIS OF PYRAZOLOPYRIMIDINES
Document Type and Number:
WIPO Patent Application WO2003022859
Kind Code:
A3
Abstract:
The present invention provides a nucleoside comprising a pyrazolopyrimidine base and a process for producing the same. In particular, the processes of the present invention comprises using a halogenated pyrazolopyrimidine base and removing the halogen after the base is coupled to a sugar moiety. The presence of the halogen on the nucleoside base allows facile and economical production of a large quantity of nucleosides.
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Inventors:
DEMPCY ROBERT O
ADAMS A DAVID
REED MICHAEL W
ADAMS A DAVID
REED MICHAEL W
Application Number:
PCT/US2002/028476
Publication Date:
December 04, 2003
Filing Date:
September 05, 2002
Export Citation:
Assignee:
EPOCH BIOSCIENCES INC (US)
International Classes:
C07H19/044; (IPC1-7): C07H19/00; C07D239/00; C07D473/00; C07H19/04
Other References:
SEELA ET AL.: "Oligonucleotides containing pyrazolo(3,4-d)pyrimidines: the influence of 7-substituted 8-aza-7-deaza-2'-deoxyguanosines on the duplex structure and stability", HELVETICA ACTA, vol. 82, 1999, pages 1640 - 1655, XP002176753
SEELA ET AL.: "Alternating d(G-C)3 and d(C-G)3 hexanucleotides containing 7-deaza-2'-deoxyguanosine or 8-aza-7-deaza-2'-deoxyguanosine in place of dG", NUCLEIC ACID RESEARCH, vol. 17, no. 3, 1989, pages 901 - 910, XP002078861
SEELA ET AL.: "131.8-Aza-7-deaza-2'-deoxyguanosine: phosphramidite synthesis and properties of octanucleotides", HELVETICA CHIMICA ACTA, vol. 71, 1988, pages 1191 - 1198, XP002078862
See also references of EP 1427743A4
SEELA ET AL.: "Alternating d(G-C)3 and d(C-G)3 hexanucleotides containing 7-deaza-2'-deoxyguanosine or 8-aza-7-deaza-2'-deoxyguanosine in place of dG", NUCLEIC ACID RESEARCH, vol. 17, no. 3, 1989, pages 901 - 910, XP002078861
SEELA ET AL.: "131.8-Aza-7-deaza-2'-deoxyguanosine: phosphramidite synthesis and properties of octanucleotides", HELVETICA CHIMICA ACTA, vol. 71, 1988, pages 1191 - 1198, XP002078862
See also references of EP 1427743A4
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