PYRIDAZINONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT

WIPO Patent Application WO/2008/156094

A1

Disclosed is a novel pyridazinone derivative represented by the general formula (1) below, which is useful as a pharmaceutical product having phosphodiesterase inhibitory activity.

JP2023549074	Pyrimidine compounds, compositions and their pharmaceutical uses
WO/2006/082392	PYRAZOLYLAMINOPYRIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS

KOHNO YASUSHI (JP)
OCHIAI KOJI (JP)
TAKITA SATOSHI (JP)
KOJIMA AKIHIKO (JP)
EIRAKU TOMOHIKO (JP)
KISHI TETSUYA (JP)

PCT/JP2008/061087

December 24, 2008

June 18, 2008

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KYORIN SEIYAKU KK (JP)
KOHNO YASUSHI (JP)
OCHIAI KOJI (JP)
TAKITA SATOSHI (JP)
KOJIMA AKIHIKO (JP)
EIRAKU TOMOHIKO (JP)
KISHI TETSUYA (JP)

C07D401/14; A61K31/501; A61P1/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P11/16; A61P17/00; A61P17/04; A61P19/02; A61P25/00; A61P25/16; A61P25/24; A61P25/28; A61P27/16; A61P29/00; A61P37/08; A61P43/00; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D471/04

WO2006095666A1	2006-09-14
WO2008029882A1	2008-03-13

JP2007119397A	2007-05-17
JP2008024599A	2008-02-07
JP2008063265A	2008-03-21

VAN DER MEY ET AL.: "Synthesis and Structure-Activity Relationships of cis-Tetrahydrophthalazinone/Pyridazinone Hybrids: A Novel Series of Potent Dual PDE3/PDE4 Inhibitory Agents", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 10, 2003, pages 2008 - 2016, XP008126345

MIZUNO, Katsufumi et al. (2-3 Marunouchi 2-chome, Chiyoda-k, Tokyo 05, JP)

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