Title:
RAAV-VECTORED RIBOZYME COMPOSITIONS AND METHODS FOR THE TREATMENT OF RETINAL DISEASES
Document Type and Number:
WIPO Patent Application WO2002088320
Kind Code:
A3
Abstract:
Disclosed are ribozymes, as well as compositions, vectors, virus particles, host cells, and therapeutic kits that comprise them, which have been shown to be useful in the manufacture of medicaments and in the treatment of diseases of the mammalian eye, and in particular retinopathy and macular degeneration. Also disclosed are methods and uses of these compositions in the reduction, elimination, and/or amelioration of symptoms of diseases of the human eye, including for example, loss of vision, retinitis, retinopathy, and blindness.
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Inventors:
LEWIN ALFRED S (US)
SHAW LYNN C (US)
GRANT MARIA B (US)
SHAW LYNN C (US)
GRANT MARIA B (US)
Application Number:
PCT/US2002/013679
Publication Date:
June 02, 2005
Filing Date:
May 01, 2002
Export Citation:
Assignee:
UNIV FLORIDA (US)
LEWIN ALFRED S (US)
SHAW LYNN C (US)
GRANT MARIA B (US)
LEWIN ALFRED S (US)
SHAW LYNN C (US)
GRANT MARIA B (US)
International Classes:
C12N15/113; A61K38/00; (IPC1-7): A61K48/00; C07H21/00; C12Q1/68
Other References:
CORDIERO M.F. ET AL: "Molecular Therapy in ocular wound healing", BJO ONLINE, vol. 83, 1999, pages 1219 - 1224
FARRAR ET AL: "On the Genetics of retinits Pignentosa and on Mutation-independent Approaches to Therapeutic Intervention", EMBO JOURNAL, vol. 21, no. 5, 2002, pages 857 - 864
BERGSLAND E. ET AL: "Update on Clinical Trials Targeting Vascular Endothelial Growth Factor in Cancer", AM. J. HEALTH SYST. PHARM., vol. 61, no. 5, November 2004 (2004-11-01), pages S12 - S20
FARRAR ET AL: "On the Genetics of retinits Pignentosa and on Mutation-independent Approaches to Therapeutic Intervention", EMBO JOURNAL, vol. 21, no. 5, 2002, pages 857 - 864
BERGSLAND E. ET AL: "Update on Clinical Trials Targeting Vascular Endothelial Growth Factor in Cancer", AM. J. HEALTH SYST. PHARM., vol. 61, no. 5, November 2004 (2004-11-01), pages S12 - S20
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