Title:
RECOMBINANT MUTANT MICROORGANISM HAVING MALONIC ACID PRODUCTION CAPABILITY AND METHOD FOR PRODUCING MALONIC ACID USING SAME
Document Type and Number:
WIPO Patent Application WO/2017/122984
Kind Code:
A1
Abstract:
The present invention relates to a recombinant mutant microorganism having malonic acid production capability, and a method for producing malonic acid using the same and, more particularly, to a mutant microorganism having malonic acid production capability, resulting from the introduction of a semialdehyde dehydrogenase-encoding gene into a microorganism capable of producing malonic semialdehyde, and a method for producing malonic acid using the same. Biologically expressing an enzyme having semialdehyde dehydrogenase activity, the mutant microorganism according to the present invention is useful for effectively producing malonic acid from beta alanine or various carbon sources, with malonic semialdehyde used as an intermediate.
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Inventors:
LEE SANG YUP (KR)
SONG CHAN WOO (KR)
KO YOOSUNG (KR)
KIM JE WOONG (KR)
SONG CHAN WOO (KR)
KO YOOSUNG (KR)
KIM JE WOONG (KR)
Application Number:
PCT/KR2017/000319
Publication Date:
July 20, 2017
Filing Date:
January 10, 2017
Export Citation:
Assignee:
KOREA ADVANCED INST SCI & TECH (KR)
HANWHA CHEMICAL CORP (KR)
HANWHA CHEMICAL CORP (KR)
International Classes:
C12N15/63; C12N9/02; C12P7/46
Domestic Patent References:
| WO2013134424A1 | 2013-09-12 |
Foreign References:
| JP2015531237A | 2015-11-02 | |||
| KR20080069678A | 2008-07-28 | |||
| KR20100015743A | 2010-02-12 | |||
| KR20120108538A | 2012-10-05 |
Other References:
SONG ET AL.: "Metabolic Engineering of Eschehchia Coli for the Production of 3-hydroxypropionic Acid and Malonic Acid through beta-alanine Route", ACS SYNTHETIC BIOLOGY, vol. 5, 29 February 2016 (2016-02-29), pages 1256 - 1263, XP055398757
See also references of EP 3415628A4
See also references of EP 3415628A4
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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