Title:
REDUCED HYALURONATE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/125957
Kind Code:
A1
Abstract:
The present application provides a preparation method for reduced hyaluronate. The method comprises the following steps: reacting sodium ascorbate with haloalkyl alcohol in water; and adding a hyaluronic acid or a salt thereof and an activator for reaction, so as to obtain reduced hyaluronate. The reduced hyaluronate of the present application not only has the efficacy of the hyaluronic acid such as the moisturizing effect, anti-inflammation, and promoting cell growth, but also has the efficacy of vitamin C such as brightening the skin, promoting collagen formation, and inhibiting melanin, and the substance improves the stability of vitamin C, and improves the penetration of vitamin C in the skin at the same time.
Inventors:
WANG CHENGSHAN (CN)
WEI JIAN (CN)
GUO XUEPING (CN)
ZHU LIANMING (CN)
BIAN ZHAOQUAN (CN)
WEI JIAN (CN)
GUO XUEPING (CN)
ZHU LIANMING (CN)
BIAN ZHAOQUAN (CN)
Application Number:
PCT/CN2022/144027
Publication Date:
July 06, 2023
Filing Date:
December 30, 2022
Export Citation:
Assignee:
BLOOMAGE BIOTECHNOLOGY CORP LTD (CN)
DONGYING FIRST BIOCHEM IND CO LTD (CN)
DONGYING FIRST BIOCHEM IND CO LTD (CN)
International Classes:
C08B37/08
Foreign References:
| CN113527537A | 2021-10-22 | |||
| CN101801947A | 2010-08-11 | |||
| CN101130534A | 2008-02-27 | |||
| CN101824011A | 2010-09-08 | |||
| CN104436203A | 2015-03-25 | |||
| CN106565646A | 2017-04-19 | |||
| CN110343096A | 2019-10-18 | |||
| CN110467689A | 2019-11-19 | |||
| FR3080765A1 | 2019-11-08 | |||
| JP2010064966A | 2010-03-25 | |||
| US20070093425A1 | 2007-04-26 | |||
| JP2005320310A | 2005-11-17 | |||
| US20120283428A1 | 2012-11-08 | |||
| RU2008122424A | 2009-12-10 |
Other References:
POSS A. J., BELTER R. K.: "The C-Alkylation of Ascorbic Acid", SYNTHETIC COMMUNICATIONS, TAYLOR & FRANCIS INC., US, vol. 18, no. 4, 31 December 1988 (1988-12-31), US , pages 417 - 423, XP009546758, ISSN: 0039-7911, DOI: 10.1080/00397918808064004
TAHIR HASAN, OLE HINDSGAUL: "Regio- and Chemoselective Alkylation of L-Ascorbic Acid under Mitsunobu Conditions", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 65, no. 3, 19 January 2000 (2000-01-19), pages 911 - 913, XP093075102, DOI: 10.1021/jo990606+
TAHIR HASAN, OLE HINDSGAUL: "Regio- and Chemoselective Alkylation of L-Ascorbic Acid under Mitsunobu Conditions", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 65, no. 3, 19 January 2000 (2000-01-19), pages 911 - 913, XP093075102, DOI: 10.1021/jo990606+
Attorney, Agent or Firm:
BEIJING TANGSONG IP FIRM (CN)
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