Title:
SEMI-SYNTHETIC SAPONIN ANALOGS WITH CARRIER AND IMMUNE STIMULATORY ACTIVITIES FOR DNA AND RNA VACCINES
Document Type and Number:
WIPO Patent Application WO2004092329
Kind Code:
A3
Abstract:
The present invention discloses novel saponin derivatives for use with nucleic acids that induce an immune response when administered to animals and humans. The novel saponin derivatives disclosed comprise (a) a saponin aglycone core, wherein the aglycone core is covalently linked to one or more oligosaccharide chains; (b) a positively charged cationic chain, and optionally (c) a naturally occurring or synthetic lipophilic chain. Pharmaceutical and veterinary compositions comprising one or more of the novel saponin derivatives and saponin derivative/polynucleotide complexes are also disclosed. Disclosed as well are methods of using the novel saponin derivatives to deliver a polynucleotide molecule to cells of an animal, to stimulate or generate an immune response in an animal, and to generate a detectable immune response in an animal.
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Inventors:
MARCIANI DANTE J (US)
Application Number:
PCT/US2004/010609
Publication Date:
February 17, 2005
Filing Date:
April 08, 2004
Export Citation:
Assignee:
GALENICA PHARMACEUTICALS INC (US)
MARCIANI DANTE J (US)
MARCIANI DANTE J (US)
International Classes:
A61K31/70; A61K31/704; C07G3/00; C07G11/00; C07H15/24; C07J17/00; C12N; (IPC1-7): C07G3/00; C07G11/00; A61K31/70
Domestic Patent References:
| WO2002102407A1 | 2002-12-27 |
Other References:
SASAKI ET AL.: "Induction of Systemic and Mucosal Immune Responses to Human Immunodeficiency Virus Type I by a DNA Vaccine Formulated with QS-21 Saponin Adjuvant via Intramuscular and Intranasal Routes", J. VIROLOGY, vol. 72, no. 6, June 1998 (1998-06-01), pages 4931 - 4939, XP002121092
SINGH ET AL.: "Advances in vaccine adjuvants", NATURE BIOTECHNOLOGY, vol. 17, November 1999 (1999-11-01), pages 1075 - 1081, XP000999107
SAHU ET AL.: "Triterpenoid Saponins From GYMNEMA SYLVESTRE", PHYTOCHEMISTRY, vol. 41, no. 4, March 1996 (1996-03-01), pages 1181 - 1185, XP002983390
SINGH ET AL.: "Advances in vaccine adjuvants", NATURE BIOTECHNOLOGY, vol. 17, November 1999 (1999-11-01), pages 1075 - 1081, XP000999107
SAHU ET AL.: "Triterpenoid Saponins From GYMNEMA SYLVESTRE", PHYTOCHEMISTRY, vol. 41, no. 4, March 1996 (1996-03-01), pages 1181 - 1185, XP002983390
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