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Title:
SOLID PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2016/063544
Kind Code:
A1
Abstract:
[Problem] Provided is a pharmaceutical composition which suppresses gelation of the 7-{(3S,4S)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride and which suppresses elution delay. [Solution] This solid pharmaceutical composition is obtained by using crystals (B-form crystals) of a hydrate of 7-{(3S,4S)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride, having peaks at 9.4 and 17.7 degrees (±0.2 degrees for each) as 2θ diffraction angles in X-ray powder diffraction using CuKα emission.

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Inventors:
UCHIDA HIROSHI (JP)
HANADA MASATAKA (JP)
Application Number:
PCT/JP2015/005344
Publication Date:
April 28, 2016
Filing Date:
October 23, 2015
Export Citation:
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Assignee:
KYORIN SEIYAKU KK (JP)
International Classes:
A61K31/4709; A61K9/20; A61P31/04
Domestic Patent References:
WO2013069297A12013-05-16
WO2013145749A12013-10-03
WO2013145750A12013-10-03
WO2006059716A12006-06-08
WO2006059716A12006-06-08
Foreign References:
JP2013043834A2013-03-04
JP2002505290A2002-02-19
Other References:
See also references of EP 3210608A4
Attorney, Agent or Firm:
MIZUNO, Katsufumi et al. (JP)
Katsufumi Mizuno (JP)
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