Title:
SPHINGOLIPID COMPOUND, LIPOSOME CONTAINING SPHINGOLIPID COMPOUND, AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2023/193341
Kind Code:
A1
Abstract:
Provided are a sphingolipid compound shown in formula (I), a liposome containing the sphingolipid compound, and an application. The sphingolipid compound is prepared by taking a long-chain alkyl group as a hydrophobic tail part, and bonding same to a hydrophilic head part by means of a connecting arm. The sphingolipid compound is applied to a cationic liposome to obtain a low-toxicity cationic liposome having high transfection efficiency and good stability.
Inventors:
JIANG ZHI-HONG (CN)
BAI LI-PING (CN)
XU TING (CN)
ZHOU XIAOBO (CN)
GUO YONG (CN)
BAI LI-PING (CN)
XU TING (CN)
ZHOU XIAOBO (CN)
GUO YONG (CN)
Application Number:
PCT/CN2022/098765
Publication Date:
October 12, 2023
Filing Date:
June 14, 2022
Export Citation:
Assignee:
UNIV MACAU SCI & TECH (CN)
International Classes:
C07D249/04; A61K9/127; A61K31/337; A61K47/20; A61K47/22; A61P9/00; A61P29/00; A61P31/00; A61P35/00; C07C231/12; C07C237/10; C07C335/32; C07D233/64; C07D317/28; C07D403/12
Domestic Patent References:
| WO2000037046A1 | 2000-06-29 | |||
| WO1995032002A1 | 1995-11-30 |
Foreign References:
| CN1148391A | 1997-04-23 | |||
| CN113121381A | 2021-07-16 | |||
| CN1829535A | 2006-09-06 | |||
| CN105152939A | 2015-12-16 |
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
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