Title:
SULFONAMIDE DERIVATIVES HAVING CYCLIC STRUCTURES
Document Type and Number:
WIPO Patent Application WO/2000/046189
Kind Code:
A1
Abstract:
Sulfonamide derivatives having matrix metalloprotease inhibiting effects, which are compounds represented by general formula (I), optical isomers of the same, pharmaceutically acceptable salts of both, or hydrates of them: wherein A is a group represented by, e.g., formula (II) or (III): R?1¿ is -COOR?6¿ or the like; R?2¿ is optionally substituted arylene or the like; R?3¿ is -CO-NH- or the like; R?4¿ is optionally substituted aryl or the like; R?5¿ is hydrogen or the like; and m and n are each independently 0 or 1.
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Inventors:
WATANABE FUMIHIKO (JP)
TSUZUKI HIROSHIGE (JP)
TSUZUKI HIROSHIGE (JP)
Application Number:
PCT/JP2000/000446
Publication Date:
August 10, 2000
Filing Date:
January 28, 2000
Export Citation:
Assignee:
SHIONOGI & CO (JP)
WATANABE FUMIHIKO (JP)
TSUZUKI HIROSHIGE (JP)
WATANABE FUMIHIKO (JP)
TSUZUKI HIROSHIGE (JP)
International Classes:
A61P9/04; A61P13/12; A61P19/02; A61P35/00; A61P37/02; A61P43/00; C07C311/20; C07C311/29; C07C311/43; C07C311/46; C07C323/49; C07C327/30; C07D257/04; C07D271/07; C07D271/107; C07D307/91; C07D333/34; C07D409/04; C07D409/10; C07D413/04; C07D471/04; C07D493/08; C07D271/06; C07D271/10; (IPC1-7): C07C311/15; A61K31/18; A61K31/19; A61K31/34; A61K31/38; A61K31/40; A61K31/41; A61K31/42; A61K31/435; A61K31/44; A61K31/445; A61K31/535; A61P9/04; A61P13/12; A61P19/02; A61P35/00; A61P37/02; A61P43/00; C07C311/14; C07D257/04; C07D271/06; C07D271/10; C07D307/91; C07D333/34; C07D409/04; C07D409/10; C07D413/04; C07D471/04; C07D493/08
Domestic Patent References:
| WO1998016506A1 | 1998-04-23 |
Foreign References:
| JPH09241227A | 1997-09-16 | |||
| JPH0475589A | 1992-03-10 | |||
| JPH0377862A | 1991-04-03 | |||
| DE3720760A1 | 1989-01-05 |
Other References:
YOSHITSUGU ARAI ET AL.: "Novel route to some biologically important compounds starting with a common chiral, bicyclic, fused lactone: enantioselective synthesis of (-)-boschnialactone and two antithrombotics", J. CHEM. SOC., PERKIN TRANS. 1,, vol. 12, 1991, pages 2969 - 2975, XP002928240
ARTHUR G. SCHULTZ ET AL.: "Enatioselective conversion of anthranilic acid derivatives to chiral cyclohexanes. Total synthesis of (+)-pumiliotoxin C", J. AM. CHEM. SOC.,, vol. 109, no. 21, 1987, pages 6493 - 6502, XP002928239
ARTHUR G. SCHULTZ ET AL.: "Enatioselective conversion of anthranilic acid derivatives to chiral cyclohexanes. Total synthesis of (+)-pumiliotoxin C", J. AM. CHEM. SOC.,, vol. 109, no. 21, 1987, pages 6493 - 6502, XP002928239
Attorney, Agent or Firm:
Yamauchi, Hideaki (Patent Dept. 12-, Sagisu 5-chome Fukushima-ku Osaka-shi Osaka, JP)
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