SYNTHESIS METHOD FOR LOW-TRANSOLEATE CONTENT POLYSORBATE 80 FOR INJECTION

Title:

SYNTHESIS METHOD FOR LOW-TRANSOLEATE CONTENT POLYSORBATE 80 FOR INJECTION

Document Type and Number:

WIPO Patent Application WO/2020/024500

Kind Code:

A1

Abstract:

A synthesis method for low-transoleate content polysorbate 80 for injection, comprising the following synthesis steps: mixing polyoxyethylene (20) sorbitol anhydride and high-purity low-carbon oleic acid alcohol ester according to a certain ratio, performing transesterification reaction under the action of a catalyst and in vacuum, and then performing refinement, sterilization, and removal of a pyrogen to obtain the polysorbate 80 for injection. The mass ratio of the polyoxyethylene (20) sorbitol anhydride to the high-purity low-carbon oleic acid alcohol ester ranges from 1:0.3 to 1:0.5. Compared with other methods, the method has the advantages as follows: the reaction temperature is lowered, conversion between cis-trans isomers of the oleic acid is effectively inhibited, so that the content of transoleate in the polysorbate 80 is reduced to be lower than or equal to 0.3%, and the chroma (APHA) is reduced to be lower than or equal to 30, and the biosafety of the polysorbate 80 is improved, moreover, the process operations are simplified, the process production efficiency is improved, and the production costs are reduced.

More Like This:

WO/2016/063875	MALEIMIDE RESIN COMPOUND HAVING EXCELLENT STORAGE STABILITY
JP3023053	AZIDE POLYMER DERIVATIZED WITH DIPOLAROPHILE
JP3930575	COPOLYMER, PREPARATION THEREOF AND USE OF THIS COPOLYMER IN PREPARATION OF IONICALLY CONDUCTIVE MATERIAL

Inventors:

WU MINGLANG (CN)
FU XIN (CN)
ZHU BING (CN)
PAN JINGJING (CN)
GAO ZHENGSONG (CN)
SHI CHEN (CN)
WANG BAOCHENG (CN)
LI HONGLI (CN)
WU YANGBO (CN)

Application Number:

PCT/CN2018/119068

Publication Date:

February 06, 2020

Filing Date:

December 04, 2018

Export Citation:

Click for automatic bibliography generation Help

Assignee:

NANJING WEIER PHARMACEUTICAL CO LTD (CN)

International Classes:

C08G65/332; C08G65/26

Foreign References:

CN107325274A	2017-11-07
CN106519201A	2017-03-22
CN102127217A	2011-07-20

Attorney, Agent or Firm:

JIANGSU CO-FAR LAW FIRM (CN)

Download PDF:

View/Download PDF PDF Help

Previous Patent: FUNCTIONAL HEAT INSULATION DEVICE FOR LITHIUM BATTERY

Next Patent: SMART LOCK COMPRISING INDEPENDENT PUSH-PULL MODULE