Title:
TALAROMYCES MARNEFFEI MANNAN PROTEIN AND USE THEREOF IN PREPARATION OF TALAROMYCES MARNEFFEI ANTIBODY TEST KIT
Document Type and Number:
WIPO Patent Application WO/2023/142410
Kind Code:
A1
Abstract:
Provided are a talaromyces marneffei mannan protein and a use thereof in preparation of a talaromyces marneffei antibody test kit. The amino acid sequence of the mannan protein is as shown in SEQ ID NO. 1. The mannan protein can bind to a talaromyces marneffei antibody and has good sensitivity and specificity, the sensitivity reaches 85.1%, and the specificity reaches 100%.
More Like This:
Inventors:
YANG GUANG (CN)
PENG JIE (CN)
YAN JUN (CN)
SHENG CHANGZHONG (CN)
SU YAN (CN)
ZHOU ZEQI (CN)
PENG JIE (CN)
YAN JUN (CN)
SHENG CHANGZHONG (CN)
SU YAN (CN)
ZHOU ZEQI (CN)
Application Number:
PCT/CN2022/108077
Publication Date:
August 03, 2023
Filing Date:
July 27, 2022
Export Citation:
Assignee:
DYNAMIKER BIOTECHNOLOGY TIANJIN CO LTD (CN)
International Classes:
C07K1/22; C07K14/385; C12N15/31; C12N15/70
Domestic Patent References:
| WO2021179246A1 | 2021-09-16 |
Foreign References:
| CN114106118A | 2022-03-01 | |||
| US5973131A | 1999-10-26 | |||
| US20120064093A1 | 2012-03-15 | |||
| CN113087779A | 2021-07-09 | |||
| CN108896761A | 2018-11-27 |
Other References:
DATABASE Protein 2 March 1998 (1998-03-02), CAO LIANG ET AL.: "cell wall antigen [Talaromyces marneffei]", XP093082082, retrieved from NCBI Database accession no. AAC39367.1
LIAO SHUANG, TUNG EDWARD T.K., ZHENG WEI, CHONG KEN, XU YUANYUAN, DAI PENG, GUO YINGYING, BARTLAM MARK, YUEN KWOK-YUNG, RAO ZIHE: "Crystal Structure of the Mp1p Ligand Binding Domain 2 Reveals Its Function as a Fatty Acid-binding Protein", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 285, no. 12, 1 March 2010 (2010-03-01), US , pages 9211 - 9220, XP093082083, ISSN: 0021-9258, DOI: 10.1074/jbc.M109.057760
SHI, GANGHONG ET AL.: "Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response", CELL CHEMICAL BIOLOGY, vol. 24, 16 February 2017 (2017-02-16), pages 182 - 194, XP029924428, DOI: 10.1016/j.chembiol.2016.12.014
LIAO SHUANG, TUNG EDWARD T.K., ZHENG WEI, CHONG KEN, XU YUANYUAN, DAI PENG, GUO YINGYING, BARTLAM MARK, YUEN KWOK-YUNG, RAO ZIHE: "Crystal Structure of the Mp1p Ligand Binding Domain 2 Reveals Its Function as a Fatty Acid-binding Protein", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 285, no. 12, 1 March 2010 (2010-03-01), US , pages 9211 - 9220, XP093082083, ISSN: 0021-9258, DOI: 10.1074/jbc.M109.057760
SHI, GANGHONG ET AL.: "Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response", CELL CHEMICAL BIOLOGY, vol. 24, 16 February 2017 (2017-02-16), pages 182 - 194, XP029924428, DOI: 10.1016/j.chembiol.2016.12.014
Attorney, Agent or Firm:
TIANJIN ZHIYUAN JUNZHENG PATENT AGENCY (SPECIAL GENERAL PARTNERSHIP) (CN)
Download PDF:
Previous Patent: METHOD AND APPARATUS FOR ADJUSTING PLAYBACK VOLUME, AND DEVICE AND STORAGE MEDIUM
Next Patent: FILTER DEVICE
Next Patent: FILTER DEVICE