THROMBOLYTIC ENZYME AND METHOD OF OBTAINING SAME

WIPO Patent Application WO/1996/019999

A1

The proposed thrombolytic enzyme is capable of hydrolysing exo- and endo-'epsilon'-('gamma'-Glu)-Lys-isopeptide bonds in synthetic substrates, in stabilised fibrin and its D-D-fragment with a partial amino acid sequence and the structure of the corresponding gene and two additional genes of the same family; glycine residues are found in the primary structure of the protein at positions 15, 21, 24, 28, 33, 46, 49, 50. The proposed method of obtaining the thrombolytic enzyme from saliva or preparations containing the same from medicinal leeches involves affine chromatography on antibodies to the native enzyme immobilised on a solid substrate, followed by purification of the enzyme by ion-exchange chromatography and gel filtration.

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WO/2003/018829	6299, A HUMAN ZINC CARBOXYPEPTIDASE FAMILY MEMBER AND USES THEREFOR

SVERDLOV EVGENY DAVIDOVICH (RU)
BASKOVA IZOLDA PORFIRIEVNA (RU)
ZAVALOVA LYUDMILA LVOVNA (RU)
LUKYANOV SERGEI ANATOLIEVICH (RU)
BARSOVA EKATERINA VLADIMIROVNA (RU)
BOGDANOVA EKATERINA ANDREEVNA (RU)

PCT/RU1995/000102

July 04, 1996

May 25, 1995

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INST BIOORG CHIMII (RU)
SVERDLOV EVGENY DAVIDOVICH (RU)
BASKOVA IZOLDA PORFIRIEVNA (RU)
ZAVALOVA LYUDMILA LVOVNA (RU)
LUKYANOV SERGEI ANATOLIEVICH (RU)
BARSOVA EKATERINA VLADIMIROVNA (RU)
BOGDANOVA EKATERINA ANDREEVNA (RU)

C12N9/48; A61K35/62; A61K38/00; A61P7/02; C07K1/16; C07K1/18; C07K1/22; C07K14/435; C12N9/64; (IPC1-7): A61K35/62; A61K38/00

EP0347376A2	1989-12-20
US5114922A	1992-05-19
DE3939801A1	1991-06-06

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