Title:
TRANSDERMAL COMPOSITION CONTAINING THERAPEUTIC AGENT FOR PARKINSON'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2011/111384
Kind Code:
A1
Abstract:
Disclosed is a transdermal pharmaceutical which uses non-ergot antidopaminergic D2 receptor agonists such as ropinirole hydrochlorides or pramipexole hydrochlorides. The disclosed pharmaceutical takes into account skin safety and drug stability, exhibits excellent skin permeability, and uses the non-ergot antidopaminergic D2 receptor agonists such as ropinirole that are currently used as oral preparations in a new manner as transdermal agents. The disclosed transdermal pharmaceutical is formed by combining a non-ergot antidopaminergic D2 receptor agonist with a hydrophobic solvent and surfactant to form a minute micelle in a water-polyhydric alcohol solvent, and then preparing a colloidal solution containing the non-ergot antidopaminergic D2 receptor agonist. By selecting and adjusting the pH of the colloidal solution, the non-ergot antidopaminergic D2 receptor agonists project from the exterior of the micelle, increasing the transdermal absorbability and the initial permeability of the non-ergot antidopaminergic D2 receptor agonists.
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Inventors:
YAMASAKI KEIKO (JP)
Application Number:
PCT/JP2011/001381
Publication Date:
September 15, 2011
Filing Date:
March 09, 2011
Export Citation:
Assignee:
MEDRX CO LTD (JP)
YAMASAKI KEIKO (JP)
YAMASAKI KEIKO (JP)
International Classes:
A61K45/08; A61K9/107; A61K31/404; A61K47/04; A61K47/10; A61K47/12; A61K47/14; A61K47/16; A61K47/34; A61P25/14; A61P25/16; A61P43/00; C07D209/34
Domestic Patent References:
| WO2008108286A1 | 2008-09-12 |
Other References:
AZEEM A. ET AL.: "Nanocarrier for the transdermal delivery of an antiparkinsonian drug.", AAPS PHARMSCITECH, vol. 10, no. 4, 2009, pages 1093 - 1103
AZEEM A. ET AL.: "Nanoemulsion components screening and selection: a technical note.", AAPS PHARMSCITECH, vol. 10, no. 1, 2009, pages 69 - 76, XP055229545, DOI: doi:10.1208/s12249-008-9178-x
DIXIT N. ET AL.: "Nanoemulsion system for the transdermal delivery of a poorly soluble cardiovascular drug.", PDA JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, vol. 62, no. 1, 2008, pages 46 - 55
KUMAR D. ET AL.: "Investigation of a nanoemulsion as vehicle for transdermal delivery of amlodipine.", PHARMAZIE, vol. 64, no. 2, 2009, pages 80 - 85
BABOOTA S. ET AL.: "Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib.", ACTA PHARMACEUTICA, vol. 57, no. 3, 2007, pages 315 - 332, XP055045444, DOI: doi:10.2478/v10007-007-0025-5
SHAKEEL F. ET AL.: "Preparation and In Vivo Evaluation of Indomethacin Loaded True Nanoemulsions.", SCIENTIA PHARMACEUTICA, vol. 78, no. 1, November 2009 (2009-11-01), pages 47 - 56
AZEEM A. ET AL.: "Nanoemulsion components screening and selection: a technical note.", AAPS PHARMSCITECH, vol. 10, no. 1, 2009, pages 69 - 76, XP055229545, DOI: doi:10.1208/s12249-008-9178-x
DIXIT N. ET AL.: "Nanoemulsion system for the transdermal delivery of a poorly soluble cardiovascular drug.", PDA JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, vol. 62, no. 1, 2008, pages 46 - 55
KUMAR D. ET AL.: "Investigation of a nanoemulsion as vehicle for transdermal delivery of amlodipine.", PHARMAZIE, vol. 64, no. 2, 2009, pages 80 - 85
BABOOTA S. ET AL.: "Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib.", ACTA PHARMACEUTICA, vol. 57, no. 3, 2007, pages 315 - 332, XP055045444, DOI: doi:10.2478/v10007-007-0025-5
SHAKEEL F. ET AL.: "Preparation and In Vivo Evaluation of Indomethacin Loaded True Nanoemulsions.", SCIENTIA PHARMACEUTICA, vol. 78, no. 1, November 2009 (2009-11-01), pages 47 - 56
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