Title:
TREATMENT AGENT FOR EPIDERMOLYSIS BULLOSA
Document Type and Number:
WIPO Patent Application WO/2018/235834
Kind Code:
A1
Abstract:
Provided is a cell preparation for treating epidermolysis bullosa, containing SSEA-3 positive pluripotent stem cells (muse cells) derived from a mesenchymal tissue of a live body or cultured mesenchymal cells. The epidermolysis bullosa is preferably epidermolysis bullosa simplex, junctional epidermolysis bullosa, or dystrophic epidermolysis bullosa.
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Inventors:
SHIMIZU HIROSHI (JP)
FUJITA YASUYUKI (JP)
MASUTOMI NAOYA (JP)
FUJITA YASUYUKI (JP)
MASUTOMI NAOYA (JP)
Application Number:
PCT/JP2018/023352
Publication Date:
December 27, 2018
Filing Date:
June 19, 2018
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
LIFE SCIENCE INST INC (JP)
LIFE SCIENCE INST INC (JP)
International Classes:
A61K35/545; A61K35/28; A61K35/33; A61K35/36; A61P17/00; A61P17/02; C12N5/071; C12N5/0775
Domestic Patent References:
| WO2012133948A1 | 2012-10-04 | |||
| WO2011007900A1 | 2011-01-20 |
Foreign References:
| JP2016056109A | 2016-04-21 | |||
| JP2016516394A | 2016-06-09 | |||
| JP5185443B2 | 2013-04-17 |
Other References:
TAMAI, KATSUTO: "comprehensive research report on practical use of mesenchymal stem cell transplantation regenerative medicine against epidermolysis bullosa", CLINICAL RESEARCH ON MESENCHYMAL STEM CELL TRANSPLANTATION, May 2015 (2015-05-01), pages 1 - 16, XP009518039
PETROF, G. ET AL.: "Potential of Systemic Allogenic Mesenchymal Stromal Cell Therapy for Children with Recessive Dystrophic Epidermolysis Bullosa", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 135, no. 9, September 2015 (2015-09-01), pages 2319 - 2321, XP055569826
TOLAR, J. ET AL.: "HEMATOPOIETIC AND MESENCHYMAL CELL TRANSPLANTATION AFTER MYELOABLATIVE AND NON- MYELOABLATIVE CONDITIONING FOR RECESSIVE DYSTROPHIC AND JUCTIONALEPIDERMOLYSIS BULOSA (RDEB, JEB)", WOUND REP. REG., vol. 20, 2012, pages A67, XP009518042, DOI: 10.1111/j.1524-475X.2012.00835.x
SHIN, K. C. ET AL.: "The Use of Cultured Allogenic Keratinocyte Grafting in a Patient with Epidermolysis Bullosa Simplex", ANN. DERMATOL., vol. 23, no. Suppl 3, 2011, pages S393 - S397, XP055569832
ZARE, S. ET AL.: "Application of Allogeneic Fibroblast Cells in Cellular Therapy of Recessive Dystrophic Epidermolysis Bullosa", J. SKIN STEM CELL, vol. 2, no. 3, September 2015 (2015-09-01), pages e30787, XP055569835
DEZAWA, M.: "Muse Cells Provide the Pluripotency of Mesenchymal Stem Cells; Direct Contribution of Muse Cells to Tissue Regeneration", CELL TRANSPLANTATION, vol. 25, no. 5, May 2016 (2016-05-01), pages 849 - 861, XP055569840
PAUNESCU, V. ET AL.: "In vitro differentiation of Human mesenchymal stem cells to epithelial lineage", J. CELL . MOL. MED., vol. 11, no. 3, May 2007 (2007-05-01), pages 502 - 508, XP055569844
ITOH, M. ET AL.: "817: Differentiation of human induced pluripotent stem cells into dermal fibroblast", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 132, no. Suppl 1, 2012, pages S140, XP055569850
FUJITA, Y. ET AL.: "186: CL2020, a human multilineage- differentiating stress enduring cells-rich product, has a potential to treat dystrophic epidermolysis bullosa", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 137, no. 10, October 2017 (2017-10-01), pages S224, XP055569852
YAMAUCHI, T. ET AL.: "The Potential of Muse cells for Regenerative Medicine of Skin: Procedures to Reconstitute Skin with Muse Cell -Derived Keratinocytes, Fibroblasts, and Melanocytes", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 137, no. 12, 14 October 2017 (2017-10-14), pages 2639 - 2642, XP055569856
TAMAI K., J NATL INST PUBLIC HEALTH, vol. 60, 2011, pages 118 - 124
CHINO T ET AL., AM J PATHOL, vol. 173, 2008, pages 803 - 814
WAKAO S ET AL., PROC NATL ACAD SCI USA, vol. 108, 2011, pages 9875 - 9880
WAGNER JE ET AL., N ENGL J MED, vol. 363, 2010, pages 629 - 639
CONGET P ET AL., CYTOTHERAPY, vol. 12, 2010, pages 429 - 431
PETROF G ET AL., J INVEST DERMATOL, vol. 135, 2015, pages 2319 - 2321
EL-DAROUTI M ET AL., DERMATOL THER, vol. 29, 2016, pages 96 - 100
KURODA Y ET AL., PROC NATL ACAD SCI USA, vol. 107, 2010, pages 8639 - 8643
KURODA Y ET AL., NAT PROTC, vol. 8, 2013, pages 1391 - 1415
OGURA, F. ET AL., STEM CELLS DEV., 20 November 2013 (2013-11-20)
NAT MED., vol. 13, no. 3, March 2007 (2007-03-01), pages 378 - 83
See also references of EP 3643316A4
PETROF, G. ET AL.: "Potential of Systemic Allogenic Mesenchymal Stromal Cell Therapy for Children with Recessive Dystrophic Epidermolysis Bullosa", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 135, no. 9, September 2015 (2015-09-01), pages 2319 - 2321, XP055569826
TOLAR, J. ET AL.: "HEMATOPOIETIC AND MESENCHYMAL CELL TRANSPLANTATION AFTER MYELOABLATIVE AND NON- MYELOABLATIVE CONDITIONING FOR RECESSIVE DYSTROPHIC AND JUCTIONALEPIDERMOLYSIS BULOSA (RDEB, JEB)", WOUND REP. REG., vol. 20, 2012, pages A67, XP009518042, DOI: 10.1111/j.1524-475X.2012.00835.x
SHIN, K. C. ET AL.: "The Use of Cultured Allogenic Keratinocyte Grafting in a Patient with Epidermolysis Bullosa Simplex", ANN. DERMATOL., vol. 23, no. Suppl 3, 2011, pages S393 - S397, XP055569832
ZARE, S. ET AL.: "Application of Allogeneic Fibroblast Cells in Cellular Therapy of Recessive Dystrophic Epidermolysis Bullosa", J. SKIN STEM CELL, vol. 2, no. 3, September 2015 (2015-09-01), pages e30787, XP055569835
DEZAWA, M.: "Muse Cells Provide the Pluripotency of Mesenchymal Stem Cells; Direct Contribution of Muse Cells to Tissue Regeneration", CELL TRANSPLANTATION, vol. 25, no. 5, May 2016 (2016-05-01), pages 849 - 861, XP055569840
PAUNESCU, V. ET AL.: "In vitro differentiation of Human mesenchymal stem cells to epithelial lineage", J. CELL . MOL. MED., vol. 11, no. 3, May 2007 (2007-05-01), pages 502 - 508, XP055569844
ITOH, M. ET AL.: "817: Differentiation of human induced pluripotent stem cells into dermal fibroblast", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 132, no. Suppl 1, 2012, pages S140, XP055569850
FUJITA, Y. ET AL.: "186: CL2020, a human multilineage- differentiating stress enduring cells-rich product, has a potential to treat dystrophic epidermolysis bullosa", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 137, no. 10, October 2017 (2017-10-01), pages S224, XP055569852
YAMAUCHI, T. ET AL.: "The Potential of Muse cells for Regenerative Medicine of Skin: Procedures to Reconstitute Skin with Muse Cell -Derived Keratinocytes, Fibroblasts, and Melanocytes", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 137, no. 12, 14 October 2017 (2017-10-14), pages 2639 - 2642, XP055569856
TAMAI K., J NATL INST PUBLIC HEALTH, vol. 60, 2011, pages 118 - 124
CHINO T ET AL., AM J PATHOL, vol. 173, 2008, pages 803 - 814
WAKAO S ET AL., PROC NATL ACAD SCI USA, vol. 108, 2011, pages 9875 - 9880
WAGNER JE ET AL., N ENGL J MED, vol. 363, 2010, pages 629 - 639
CONGET P ET AL., CYTOTHERAPY, vol. 12, 2010, pages 429 - 431
PETROF G ET AL., J INVEST DERMATOL, vol. 135, 2015, pages 2319 - 2321
EL-DAROUTI M ET AL., DERMATOL THER, vol. 29, 2016, pages 96 - 100
KURODA Y ET AL., PROC NATL ACAD SCI USA, vol. 107, 2010, pages 8639 - 8643
KURODA Y ET AL., NAT PROTC, vol. 8, 2013, pages 1391 - 1415
OGURA, F. ET AL., STEM CELLS DEV., 20 November 2013 (2013-11-20)
NAT MED., vol. 13, no. 3, March 2007 (2007-03-01), pages 378 - 83
See also references of EP 3643316A4
Attorney, Agent or Firm:
SANUKI, Shinichi et al. (JP)
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