Title:
A USE OF GALANTAMINE FOR THE TREATMENT OF NEUROPSYCHIATRIC BEHAVIOUR ASSOCIATED WITH ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO2001074339
Kind Code:
A3
Abstract:
Galantamine has been used in the treatment of a number of chronic diseases. Galantamine has been found to be safe and effective in the treatment of Alzheimer's disease. Neuropsychiatric disorders are often associated with Alzheimer's disease. It is demonstrated that galantamine is also effective in reducing or stabilizing the incidence of neuropsychiatric behaviour seen in Alzheimer's patients.
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Inventors:
PARYS WIM LOUIS JULIEN (US)
PONTECORVO MICHAEL (US)
PONTECORVO MICHAEL (US)
Application Number:
PCT/EP2001/003553
Publication Date:
September 12, 2002
Filing Date:
March 28, 2001
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NV (BE)
PARYS WIM LOUIS JULIEN (US)
PONTECORVO MICHAEL (US)
PARYS WIM LOUIS JULIEN (US)
PONTECORVO MICHAEL (US)
International Classes:
A61K31/55; A61K36/18; C07D491/08; A61P25/28; (IPC1-7): A61K31/55; A61P25/28
Domestic Patent References:
| WO1997025330A1 | 1997-07-17 | |||
| WO2000038686A1 | 2000-07-06 | |||
| WO2001074364A2 | 2001-10-11 | |||
| WO2001074365A2 | 2001-10-11 |
Foreign References:
| US4663318A | 1987-05-05 | |||
| US5877172A | 1999-03-02 |
Other References:
RAINER M ET AL: "LONG-TERM COGNITIVE BENEFIT FROM GALANTHAMINE IN ALZHEIMER'S DISEASE", INTERNATIONAL JOURNAL OF GERIATRIC PSYCHOPHARMACOLOGY, STOCKTON PRESS, BASINGSTOKE, GB, vol. 1, no. 4, 1998, pages 197 - 201, XP001022883, ISSN: 1364-8233
FULTON B ET AL: "GALANTHAMINE", DRUGS AND AGING, ADIS INTERNATIONAL LTD, NZ, vol. 9, no. 1, July 1996 (1996-07-01), pages 60 - 65, XP001022834, ISSN: 1170-229X
GREENWOOD D: "GALANTAMINE. A NOVEL TREATMENT FOR ALZHEIMER'S DISEASE", JOURNAL OF PHARMACY AND PHARMACOLOGY, LONDON, GB, vol. 50, no. SUPPL, September 1998 (1998-09-01), pages 20, XP001022488, ISSN: 0022-3573
HARVEY A L: "THE PHARMACOLOGY OF GALANTHAMINE AND ITS ANALOGUES", PHARMACOLOGY AND THERAPEUTICS, ELSEVIER, GB, vol. 68, no. 1, 1995, pages 113 - 128, XP000915592, ISSN: 0163-7258
SWEENEY J E ET AL: "EFFECTS OF DIFFERENT DOSES OF GALANTHAMINE, A LONG-ACTING ACETYLCHOLINESTERASE INHIBITOR, ON MEMORY IN MICE", PSYCHOPHARMACOLOGY, SPRINGER VERLAG, BERLIN, DE, vol. 102, no. 2, 1990, pages 191 - 200, XP001022830, ISSN: 0033-3158
KRALL W J ET AL: "CHOLINESTERASE INHIBITORS: A THERAPEUTIC STRATEGY FOR ALZHEIMER DISEASE", ANNALS OF PHARMACOTHERAPY, XX, XX, vol. 33, no. 4, April 1999 (1999-04-01), pages 441 - 450, XP001013144, ISSN: 1060-0280
NORDBERG A ET AL: "CHOLINESTERASE INHIBITORS IN THE TREATMENT OF ALZHEIMER'S DISEASE A COMPARISON OF TOLERABILITY AND PHARMACOLOGY", DRUG SAFETY, ADIS PRESS, AUCKLAND, NZ, vol. 19, no. 6, December 1998 (1998-12-01), pages 465 - 480, XP001037505, ISSN: 0114-5916
FULTON B ET AL: "GALANTHAMINE", DRUGS AND AGING, ADIS INTERNATIONAL LTD, NZ, vol. 9, no. 1, July 1996 (1996-07-01), pages 60 - 65, XP001022834, ISSN: 1170-229X
GREENWOOD D: "GALANTAMINE. A NOVEL TREATMENT FOR ALZHEIMER'S DISEASE", JOURNAL OF PHARMACY AND PHARMACOLOGY, LONDON, GB, vol. 50, no. SUPPL, September 1998 (1998-09-01), pages 20, XP001022488, ISSN: 0022-3573
HARVEY A L: "THE PHARMACOLOGY OF GALANTHAMINE AND ITS ANALOGUES", PHARMACOLOGY AND THERAPEUTICS, ELSEVIER, GB, vol. 68, no. 1, 1995, pages 113 - 128, XP000915592, ISSN: 0163-7258
SWEENEY J E ET AL: "EFFECTS OF DIFFERENT DOSES OF GALANTHAMINE, A LONG-ACTING ACETYLCHOLINESTERASE INHIBITOR, ON MEMORY IN MICE", PSYCHOPHARMACOLOGY, SPRINGER VERLAG, BERLIN, DE, vol. 102, no. 2, 1990, pages 191 - 200, XP001022830, ISSN: 0033-3158
KRALL W J ET AL: "CHOLINESTERASE INHIBITORS: A THERAPEUTIC STRATEGY FOR ALZHEIMER DISEASE", ANNALS OF PHARMACOTHERAPY, XX, XX, vol. 33, no. 4, April 1999 (1999-04-01), pages 441 - 450, XP001013144, ISSN: 1060-0280
NORDBERG A ET AL: "CHOLINESTERASE INHIBITORS IN THE TREATMENT OF ALZHEIMER'S DISEASE A COMPARISON OF TOLERABILITY AND PHARMACOLOGY", DRUG SAFETY, ADIS PRESS, AUCKLAND, NZ, vol. 19, no. 6, December 1998 (1998-12-01), pages 465 - 480, XP001037505, ISSN: 0114-5916
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