USE OF HEDGEHOG PATHWAY INHIBITORS IN SMALL-CELL LUNG CANCER

Title:

USE OF HEDGEHOG PATHWAY INHIBITORS IN SMALL-CELL LUNG CANCER

Document Type and Number:

WIPO Patent Application WO2005042700

Kind Code:

A3

Abstract:

Elevated Hedgehog (Hh) pathway activity, including ligand stimulated Hh pathway activity, was detected in small-cell lung cancer (SCLQ cells, and determined to be associated with growth and proliferation of the cancer cells. Accordingly, methods are provided for treating SCLC associated with elevated Hh pathway activity by reducing or inhibiting the Hh pathway activity. Also provided are methods of determining the responsiveness of SCLC to treatment with a Hh pathway antagonist.

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Inventors:

WATKINS DAVID N (US)
BERMAN DAVID M (US)
BAYLIN STEPHEN B (US)
BEACHY PHILIP A (US)

Application Number:

PCT/US2004/034534

Publication Date:

February 23, 2006

Filing Date:

October 20, 2004

Export Citation:

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Assignee:

UNIV JOHNS HOPKINS (US)
WATKINS DAVID N (US)
BERMAN DAVID M (US)
BAYLIN STEPHEN B (US)
BEACHY PHILIP A (US)

International Classes:

C12N; (IPC1-7): A61K38/00

Domestic Patent References:

WO2002080952A2

2002-10-17

Foreign References:

US20040011663A1

2004-01-22

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