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WO/2012/028676A1 |
The invention relates to new compounds of the formula (I) to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
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WO/2012/029942A1 |
Provided is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, A represents a C6-10 arylene group or the like; R1a, R1b and R1c each independently represents a hydrogen atom, a halogen ...
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WO/2012/029035A1 |
The invention relates to the use of diazonium salts for the formation of thick layers on at least one surface of a substrate. The diazonium salts used in the invention have the following formula (I): wherein R is a group that can be elec...
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WO/2012/025861A1 |
The invention provides a process for the manufacture of a compound of formula (I) using an enzyme catalysed reduction of a compound of formula (lla) or llb). Compounds of formula (I) are useful for preparing pregabalin.
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WO/2012/017932A1 |
A novel process for preparing a substituted aromatic compound such as a halogenated aromatic compound or a salt thereof from an aromatic amino compound via the decomposition of an aromatic diazonium salt in a consistently high yield by u...
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WO/2012/017680A1 |
Provided is an organic electroluminescent element that is provided in the given order with a positive electrode, a light-emitting layer, an electron transport region, and a negative electrode, and the electron transport region contains a...
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WO/2012/013563A1 |
The invention relates to a method for producing 3-dimethlaminopropylamine (DMAPA) by reacting 3- demethylaminopropionitrile (DMAPN) with hydrogen in the presence of a catalyst, characterized in that the DMAPN used has a 2-(dimethylaminom...
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WO/2012/014696A1 |
An organic electroluminescent element with significantly improved durability relative to conventional elements using charge transport materials, and a compound having a p-dicyanobenzene structure and a specific substituent. The organic e...
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WO/2012/014889A1 |
A process for producing compounds represented by formula (III), which comprises a step (1) of reacting a compound represented by formula (I) with bromine in the presence of both water and a bromide salt to form a compound represented by ...
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WO/2012/010472A1 |
The present invention relates to a process for producing 2-cyanoacetic acid anhydride, comprising the steps of a) preparing a reaction mixture, containing as reactants 2-cyanoacetic acid, and at least one C4-20 carboxylic acid anhydride ...
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WO/2012/010413A1 |
The invention relates to aryloxy-alkylene substituted hydroxyphenyl hexynoic acid derivatives of formula (I) and to their physiologically compatible salts. The compounds are suitable for, for example, the treatment of diabetes, because t...
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WO/2012/012278A2 |
Disclosed are compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically related to GPR35, and/or GPR35-hERG signaling complex. For example, disclosed are compounds for preventing and/or treat...
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WO/2012/011125A1 |
The present invention relates to compounds that have the ability to modulate the activity of GPR40 and are therefore useful in the treatment of GPR40 related disorders. In addition the invention relates to the compounds, methods for thei...
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WO/2012/007644A1 |
The invention relates to novel arylamide derivatives having formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, where R1 - R11, R', R", z and X are as defined in the claims. The arylamide derivatives of formula (...
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WO/2012/005913A1 |
Adiponitrile is made by reacting 3-pentenenitrile with hydrogen cyanide. The 3- pentenenitrile is made by reacting 1,3-butadiene with hydrogen cyanide. The 1,3- butadiene feed includes a small amount of tertiary-butylcatechol. The cataly...
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WO/2012/005918A1 |
A hydrocyanation reaction is used to react 1,3-butadiene with hydrogen cyanide in the presence of a catalyst to produce pentenenitrles, as well as reaction byproducts, such as methylglutaronitrile (MGN). The effluent from the hydrocyanat...
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WO/2012/005919A1 |
An improved multi-reaction zone process provides improved nitrile product quality and yield. In a first reaction zone, 1,3-butadiene is reacted with hydrogen cyanide in the presence of a catalyst to produce pentenenitriles comprising 3- ...
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WO/2012/005917A1 |
Adiponitrile is made by reacting 3-pentenenitrile with hydrogen cyanide. The 3- pentenenitrile is made by reacting 1,3-butadiene with hydrogen cyanide and by isomerizing 2-methyl-3-butenenitrile. Phenolic compounds, such as phenol and cr...
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WO/2012/005916A1 |
Adiponitrile is made by reacting 3-pentenenitrile with hydrogen cyanide. The 3- pentenenitrile is made by reacting 1,3-butadiene with hydrogen cyanide and by isomerizing 2-methyl-3-butenenitrile. Both reactions take place in the presence...
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WO/2012/004269A1 |
The invention relates to substituted (2-aryloxy-acetylamino)-phenyl-proprionic acid derivatives of formula I and the physiologically tolerable salts thereof. The compounds are suitable, for example, for treating diabetes, because they ef...
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WO/2012/005911A1 |
Adiponitrile is made by reacting 3-pentenenitrile with hydrogen cyanide. The 3- pentenenitrile is made by reacting 1,3-butadiene with hydrogen cyanide. The catalyst for the reaction of 1,3-butadiene with hydrogen cyanide to make 3-penten...
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WO/2012/005910A1 |
Adiponitrile is made by reacting 3-pentenenitrile with hydrogen cyanide. The 3- pentenenitrile is made by reacting 1,3-butadiene with hydrogen cyanide. The catalyst for the reaction of 1,3-butadiene with hydrogen cyanide to make 3-penten...
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WO/2012/005912A1 |
An improved multi-reaction zone process provides for improved nitrile product quality and yield. In a first reaction zone, 1,3-butadiene is reacted with hydrogen cyanide in the presence of a catalyst to produce pentenenitriles comprising...
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WO/2012/004270A1 |
The invention relates to spirocyclically substituted 1,3-propane dioxide derivatives and to their physiologically compatible salts. The invention relates to compounds of formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, A and X have ...
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WO/2012/005915A1 |
Adiponitrile is made by reacting 3-pentenenitrile with hydrogen cyanide. The 3-pentenenitrile is made by reacting 1,3-butadiene with hydrogen cyanide and by isomerizing 2-methyl-3-butenenitrile. The reaction of 1,3-butadiene with hydroge...
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WO/2011/158758A1 |
Disclosed is a process for producing a cyanohydrin, the process comprising reacting a carbonyl compound with hydrocyanic acid in a buffer solution with a pH less than 7 to obtain the cyanohydrin.
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WO/2011/154677A1 |
The present invention provides compounds of formula (I) in which, n, R1, R2 and Q are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.
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WO/2011/154140A2 |
A novel process for the preparation of N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, also known as agomelatine, Compound (I), from 7-methoxy-tetralone as starting material, and to a new crystalline form X of agomelatine.
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WO/2011/154152A1 |
The present application discloses a process for demethylating aromatic methyl ethers by reaction with 3 -mercaptopropionic acid or salts thereof. One preferred example is the demethylation of venlafaxine forming 0 - desmethylvenlafaxine.
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WO/2011/146440A1 |
Processes include providing a clarified diammonium succinate (DAS)- or monoammonium succinate (MAS)- containing fermentation broth; distilling the broth of an overhead that includes water and ammonia, and a liquid bottoms that includes S...
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WO/2011/145352A1 |
A process for the preparation of optically active cyano compounds, which includes a step of reacting an α,β-unsaturated compound having a prescribed structure with a cyanating agent in the presence of a titanium-containing catalyst tha...
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WO/2011/142178A1 |
Provided is a mixed catalyst for gas-phase catalytic oxidation or gas-phase catalytic ammoxidation reaction of propane or isobutane, wherein it is possible to obtain, from propane or isobutane and at a high yield, unsaturated acid or uns...
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WO/2011/136217A1 |
Provided is an apparatus for efficiently removing substances (catalyst surface substances) exuding from and/or attached to a catalyst surface. An apparatus which is provided with a main body and which removes catalyst surface substances ...
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WO/2011/136484A1 |
Provided are novel organic electroluminescent compounds and an organic electroluminescent device using the same. Since the organic electroluminescent compound exhibits high luminous efficiency in blue color and excellent life property, i...
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WO/2011/132575A1 |
Disclosed is an organic electroluminescent element that satisfies at a high level the minimization of a decrease in luminous efficiency after high temperature storage of the element, the minimization of changes in chromaticity; and impro...
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WO/2011/122507A1 |
An ester compound represented by formula (1): wherein R1 represents hydrogen, fluorine, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkoxymethyl, or C1-C4 alkylthiomethyl; R3 represents hydrogen or methyl, R4 represents hydrogen or C1-C4 alkyl, and...
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WO/2011/122508A1 |
An ester compound represented by formula (1): wherein R1 represents R1 represents 2-propenyl or 2-propynyl; R3 represents hydrogen or methyl, R4 represents hydrogen or C1-C4 alkyl, and R5 represents hydrogen or C1-C4 alkyl; has an excell...
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WO/2011/113718A1 |
The present invention relates to a cosmetic composition containing a combination i) of at least one screening agent of the dibenzoylmethane derivative type and ii) of at least one particular hydrophilic or water-soluble merocyanin UV-scr...
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WO/2011/113719A2 |
The present invention relates to a cosmetic composition comprising the combination i) of at least one screening agent of the dibenzoylmethane derivative type and ii) of at least one specific merocyanine dicyano or cyanoacetate derivative...
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WO/2011/111460A1 |
Disclosed is a polymer supported boron catalyst where boron that may be used in a Michael addition reaction is supported on a polymer and a method for producing a carbon-carbon addition product by a Michael addition reaction using this p...
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WO/2011/105632A1 |
A process for producing a hydroxyiminoalkenyl cyclopropanecarboxylic acid ester represented by formula (3) (wherein R1 represents an alkyl group which may have a substituent, or a halogen atom; and R2 represents an alkyl group which may ...
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WO/2011/099645A1 |
A method for producing a salt of an amine and a cyanoalkenylcyclopropanecarboxylic acid, comprising: a first step for mixing in an organic solvent a carboxylic acid compound represented by formula (2C) with at least one amine selected fr...
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WO/2011/098417A1 |
Substituted cyanobutyrates of the formula I in which the variables are defined according to the description, processes and intermediates for preparing the compounds of the formula I and their N-oxides, their agriculturally suitable salts...
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WO/2011/095576A1 |
A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.
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WO/2011/095462A1 |
The present invention relates to certain bisamide derivatives of formula (I), to processes and intermediates for preparing them, to insecticidal, acaricidal, nematicidal or molluscicidal compositions comprising them and to methods of usi...
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WO/2011/092611A1 |
Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, met...
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WO/2011/090131A1 |
A method for supplying a raw material gas to a fluidized reactor through a raw material gas dispersion unit provided in the fluidized reactor and causing a gas-phase reaction of the raw material gas, wherein an inert gas is supplied to t...
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WO/2011/088616A1 |
A preparation method for acetonitrile and/or ethanol by mixing and dehydrogenating methanol and ammonia as reactants in presence of the solid catalyst wherein copper is the main component. The present method includes providing methanol i...
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WO/2011/086570A1 |
A process for preparation of the compound (I) and salts thereof is provided. The process comprises reacting an alkali cyanide and paraformaldehyde to form a slurry of glycolonitrile followed by neutralizing, mixing the neutralized slurry...
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WO/2011/086866A1 |
Disclosed is an organic electroluminescent element which has excellent luminous efficiency and excellent durability. Also disclosed is an organic electroluminescent element which has low driving voltage and excellent durability. Specific...
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