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WO/2009/140145A1 |
A one-pot process of preparing a substituted 7-cyano quinone methide in which i) a substituted phenol is chloromethylated to form a substituted 4-chloromethylphenol; ii) converting the substituted 4-chloromethylphenol to a substituted 4-...
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WO/2009/137413A1 |
Compounds comprising formula (I) or a pharmaceutically acceptable salt thereof, are disclosed, wherein B, Y, and A are as described in claims 1-10. Methods, compositions, and medicaments related thereto are also disclosed, for treating b...
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WO/2009/137294A1 |
Processes are provided for synthesizing substituted cyclohexane carbonitriles, particularly 1-(2-ethylbutyI)cyclohexane carbonitrile. Such processes comprise deprotonizing cyclohexane carbonitrile with chloro magnesium N,N-diisopropylami...
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WO/2009/137411A1 |
Compounds comprising Formula (I) or a pharmaceutically acceptable salt thereof, are disclosed, wherein J1, J2, U1, B, Y, and A are as described in claims 1-16. Methods, compositions, and medicaments related thereto are also disclosed, fo...
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WO/2009/136646A1 |
Disclosed is a method for producing an unsaturated organic compound represented by the following formula (3): (Y1)m-1-R1-R2-(Y2)n-1 (3) (wherein Y1 represents R2 or X1; and Y2 represents R1 or B(X2)2), wherein a compound represented ...
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WO/2009/137412A1 |
Compounds comprising formula (I) or a pharmaceutically acceptable salt thereof, a dashed line represent the presence or absence of a double bond, are disclosed, wherein J1, J2, U1, B, Y, and A are as described in claims 1-12. Methods, co...
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WO/2009/132453A1 |
Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity are disclosed. Specifically, a series of compounds of subs...
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WO/2009/131246A1 |
This invention relates to a new sordarin derivative or a pharmaceutically acceptable salt thereof, which has antimicrobial activities (especially, antifungal activities), to process for preparation thereof, to a pharmaceutical compositio...
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WO/2009/129938A1 |
The present invention relates to substituted phenoxybenzamide compounds of general formula (I) : in which R1, R2, R3, R4, R5, X, R6 and q are as defined in the claims, to methods of preparing said compounds, to pharmaceutical composition...
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WO/2009/128390A1 |
Disclosed is a method for producing an optically active cyanohydrin compound represented by formula (3) (wherein Q1 and Q2 are as defined below, and * represents that the carbon atom is the optically active center), which is characterize...
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WO/2009/128326A1 |
Provided is a method of producing a 2-cyanoacrylate in which polycondensation, desolvation and depolymerization steps can be continuously carried out and thus a 2-cyanoacrylate having a high monomer purity can be effectively obtained at ...
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WO/2009/125416A2 |
The present invention provides a process for preparation of a key intermediate of valsartan in a pure form and use of this intermediate for the preparation of valsartan or a pharmaceutically acceptable salt in pure form.
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WO/2009/125853A1 |
Disclosed is a homocysteine synthase inhibitor which is useful for the prevention or treatment of a disease associated with homocysteine synthase. Specifically disclosed is a compound represented by general formula (I) [wherein each symb...
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WO/2009/124022A1 |
The invention provides amino- and amido-aminotetralin compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, and n are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opio...
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WO/2009/123109A1 |
A photosensitive transparent resin composition which is reduced in the dependence on exposure illuminance and which can stably form patterns excellent in resolution with high retention of film thickness and nearly without scum; color fil...
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WO/2009/121788A1 |
A process for the preparation of a compound of formula (Ia): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
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WO/2009/116687A2 |
There is provided a nitrile compound having an excellent controlling effect on arthropod pests represented by the formula (I): wherein m represents in integer of 0 to 4; n represents an integer of 1 to 4; q represents an integer of 0 to ...
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WO/2009/117467A2 |
Compounds comprising or a pharmaceutically acceptable salt thereof, are disclosed, wherein Y, A, R1, R2, Z and G as described in claims 1-12. Methods, compositions and medicaments related thereto are also disclosed, for treating gloucoma...
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WO/2009/114633A1 |
The present invention relates to a process for the preparation of (2S,3S)-3-amino-N- cyclopropyl-2-hydroxyalkanamides, and their use in the preparation of HCV inhibitors and cathepsin inhibitors.
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WO/2009/111553A1 |
Disclosed is a method for preparing a compound of Formula (1) comprising contacting a compound of Formula (2) with a metal cyanide reagent, a copper (I) salt reagent, an iodide salt reagent and at least one compound of Formula (3), where...
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WO/2009/106779A2 |
The invention relates to novel photosensitising compounds derived from DCA, and to methods using the same.
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WO/2009/102034A1 |
Disclosed is a commercially suitable method for efficiently producing fluoro-compounds having various molecular structures, in which two fluorine atoms are bonded to a carbon atom, in a single-step reaction. Specifically disclosed is a m...
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WO/2009/099538A1 |
A process for the ammoxidation of a saturated or unsaturated hydrocarbon to form an unsaturated nitrile, the process including the steps of contacting the hydrocarbon with ammonia, an oxygen-containing gas, and steam, in the presence of ...
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WO/2009/095324A1 |
The present invention provides novel compounds of the general formula (I), and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel compounds and medicaments, containing them. The compounds of the prese...
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WO/2009/092637A1 |
The invention relates to a method for producing hydrocarbon compounds including at least one nitrile function. The invention more particularly relates to a method for producing nitrile compounds by the hydrocyanation of compounds contain...
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WO/2009/092639A1 |
The present invention relates to a process for producing compounds comprising at least one nitrile function by hydrocyanation of a compound comprising at least one non-conjugated unsaturation. The invention proposes a process for produci...
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WO/2009/087941A1 |
Disclosed is a method for producing a cyclopropane carboxylic acid compound represented by Formula (VI), which is characterized in that a compound represented by Formula (V) and an alkali metal borohydride compound are reacted in the pre...
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WO/2009/087650A2 |
A novel process of preparation of racemic pregabalin from comprising an intermediate of structure III comprising reductive ring opening to form a structure IV followed few alternative routes that yield racemic pregabalin that is resolved...
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WO/2009/085816A1 |
Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with a metal cyanide reagent, a copper(I) salt reagent, an iodide salt reagent and at least one compound of Formula 3 wherein R1 is...
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WO/2009/086277A1 |
Tetrasubstituted benzenes that act as modulators of gamma secretase and their use in the treatment of one or more symptoms of treating neurodegenerative disorders, e.g., Alzheimer's disease, are described.
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WO/2009/084031A2 |
The present invention relates to an improved, cost effective, eco-friendly and easy t handle process to manufacture substantially pure form of (2E)-2-Cyano-3-(3,4-dihydroxy-5 nitrophenyl)-N,N-diethyl-2-propenamide or (E)- N,N-diethyl-2-c...
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WO/2009/081956A1 |
Disclosed is a method for producing a conjugated aromatic compound, which is characterized in that an aromatic compound (A) having one or two leaving groups bonded to an aromatic ring is reacted with another aromatic compound (A) having ...
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WO/2009/081758A1 |
[PROBLEMS] To provide a process for producing an oxide catalyst for use in a vapor-phase catalytic oxidation or a vapor-phase catalytic ammoxidation reaction of propane or isobutane, which process can stably produce a catalyst that can r...
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WO/2009/081483A1 |
Oxime esters represented by the general formula (I) which are useful as photopolymerization initiator; and photopoly- merization initiators containing the oxime esters as the active ingredient, which can be activated through efficient li...
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WO/2009/077186A1 |
The present invention relates to nonsteriodal progesterone receptor modulators of the general formula 1, the use of the progesterone receptor modulators for producing medicaments and also pharmaceutical compositions containing these comp...
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WO/2009/067797A1 |
Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions. Inhibition or decreasing function of these proteases can be useful in the treatment and/or prevention of these para...
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WO/2009/067597A1 |
Compounds of the formula: (I) are disclosed. The compounds act as phosphodiesterase-4 modulators, and useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions. Other embodiments are also disclosed.
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WO/2009/063120A1 |
The invention relates to a catalytic method for the production of nitriles form alcohols, such as polyols, for example glycerol, a reaction known as ammoxidation. For this purpose, the alcohol is reacted with a nitrogen source, such as, ...
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WO/2009/064025A1 |
There is provided a novel cyclopropanecarboxyate of the formula (1): wherein R1 represents a hydrogen atom, a fluorine atom, a C1-C4 alkyl group, a C2-C4 alkenyl group, a C2-C4 alkynyl group, a C1-C4 alkoxy group, a (C1-C4 alkyl)oxymethy...
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WO/2009/061991A1 |
Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with at least one alkali metal cyanide of Formula 3 and a compound of Formula 4 wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H...
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WO/2009/060173A1 |
The present invention relates to imidazoline derivatives and their use as insecticidal and acaricidal agents. The invention also extends to insecticidal and acaricidal compositions comprising such imidazoline derivatives, and to methods ...
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WO/2009/060174A1 |
The present invention relates to novel imidazoline derivatives and their use as insecticidal, acaricidal, molluscicidal and nematocidal agents. The invention also extends to insecticidal, acaricidal, molluscicidal and nematicidal composi...
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WO/2009/060378A2 |
The present invention relates to the field of perfumery. More particularly, it concerns α-substituted cyclopentanecarbonitriles or cyclohexanecarbonitriles. Said compounds are valuable perfuming ingredients having fruity and/or jasminic...
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WO/2009/055278A1 |
Cyhalofop esters are prepared by coupling 2-(4-hydroxyphenoxy)-propionic acid with 3,4-difluorobenzonitrile with base in a polar aprotic solvent (optionally including a phase-transfer catalyst), alkylating with alkyl halide, removing the...
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WO/2009/054202A1 |
A method of organic-compound reaction and a process for producing an organic compound. By the method and process, high reaction selectivity and a high yield of a target substance can be ensured according to purposes. At least two fluids ...
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WO/2009/053484A2 |
This invention relates to novel electron deficient olefins, such as certain 2-cyanoacrylates and methylidene malonates, prepared using an imine or an iminium salt.
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WO/2009/054356A1 |
Disclosed is a process for producing a cyanohydrin compound, which comprises reacting a carbonyl compound (e.g., an aldehyde compound) with hydrogen cyanide in the presence of a basic catalyst, wherein the amount of the carbonyl compound...
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WO/2009/054355A1 |
Disclosed is a process for producing a cyanohydrin compound, which is characterized by flow-reacting a carbonyl compound with hydrogen cyanide in the presence of a catalyst and can therefore reduce the retention time. The process enables...
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WO/2009/053545A2 |
The invention relates to a method for the industrial synthesis of a compound of the formula (I). The invention can be used for the synthesis of agomelatine.
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WO/2009/053482A2 |
This invention relates to novel compounds with ester linkage (s) capped with either electron deficient olefinic linkage (s) or group (s) or reactive functional groups (termed herein as 'active methylene reagents'), and curable compositio...
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