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WO/2012/080178A1 |
The application relates to the preparation of thiophenols by reacting the corresponding disulfide with hydrogen in the presence of a heterogeneous transition metal hydrogenation catalyst. If the reaction is carried out in the presence of...
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WO/2012/081712A1 |
The present process can prepare a hydroxycarboxylic acid compound of Formula (1): or a salt thereof by reacting a ketocarboxylic acid compound of Formula (2): or a salt thereof and hydrogen in the presence of a transition metal catalyst,...
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WO/2012/079164A1 |
The present invention is directed to activators of cylindrical proteases ("ACPs"), particularly ClpP, and the role thereof in the diagnosis and treatment of bacterial infections. A number of ACPs were identified that activate caseinolyti...
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WO/2012/076016A1 |
The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one anti...
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WO/2012/076560A1 |
The present invention provides a process for preparing primary amines, comprising the steps of A) providing a solution of a primary alcohol in a fluid, non-gaseous phase, B) contacting the phase with free ammonia and/or at least one ammo...
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WO/2012/072489A1 |
The invention relates to novel alpha,beta-unsaturated imines, to a method for producing same, to the use thereof for combating animal pests, including anthropods and in particular insects, and to the use thereof in vector control.
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WO/2012/068067A1 |
A mGlu2/3 receptor antagonist of the formula (I):, its uses, and methods for its preparation are described.
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WO/2012/062041A1 |
Disclosed are aromatic ketone compounds with para- or meso-substituted multifunctional groups as represented by the general formulae I-III, preparation methods thereof, and free-radical polymerization photoinitiators comprising the compo...
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WO/2012/055014A1 |
Phenylketone carboxylate compounds of Formula I, wherein n=2-6; R=C(0); -OC(O)- or -CH( OH)-; A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A snd B ...
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WO/2012/056166A1 |
A continuous process for obtaining acrolein by catalytic dehydration of glycerol or glycerin, in the presence of an acid catalyst, wherein said process comprises the concomitant regeneration of said catalyst and is carried out in a fluid...
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WO/2012/055034A1 |
Compounds of Formula I are disclosed: wherein L, A, R1, R2, R3A, R3B, R4A, R4B, R5, R6 and R7 are defined herein. The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be...
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WO/2012/039793A1 |
The present invention provides methods and compositions for treating lung cancer by cyclohexenone compounds.
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WO/2012/034472A1 |
Cyano benzenedicarboxamide compounds of formula (I), preparing methods and as agricultural insecticides uses thereof. The compounds have broad-spectrum insecticidal activities.
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WO/2012/033225A1 |
The present invention relates to a novel method for producing a pyridazinone compound and an intermediate thereof as shown in the following scheme: wherein the symbols are as defined in the specification.
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WO/2012/031307A1 |
Compounds selected from the group of N-unsubstituted or N-alkylated or N-acylated 14-O-[(amino(C0-4)alkyl-hydroxy-cycloalkyl- or bicycloalkylsulfanyl)-acetyl]-mutilins which are 14-O-[(amino(C0-4)alkyl-hydroxy-cyclobutylsulfanyl)-acetyl]...
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WO/2012/028162A1 |
A process for preparing compounds of the formula (4), wherein a mixture of an aniline (compound of the formula Q) is reacted with a thioether (compound of the formula W) in the presence of sulfuryl chloride as a chlorinating agent and of...
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WO/2012/025450A1 |
New phenylamidines are described, having general formula (I) and their use for the control of phytopathogenic fungi.
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WO/2012/026619A1 |
The present invention provides a novel process for preparing a sulfur-containing 2-ketocarboxylate compound without using any enzyme. The process comprises a step of oxidizing a hydroxyacetate compound having an optionally-substituted su...
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WO/2012/020061A1 |
The invention relates to compounds, of formula (I) in which X is CH3 or hydrogen, Z is a linear or branched C2 to C4 alkyl radical, R is a linear or branched, optionally heteroatom-substituted aliphatic, aromatic or araliphatic radical, ...
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WO/2012/016779A1 |
Sulphur-containing and sulphone-containing aromatic perfluoroalkane monomer that can be used for the manufacture of a polymer membrane intended for a fuel cell of PEM type, said functionalized monomer corresponding to the formula (I): E1...
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WO/2012/014994A1 |
Provided is a compound which can regulate a VCP activity. Specifically provided is a compound represented by formula (I) (wherein R is as defined in the description) or an oxide, ester, prodrug, pharmaceutically acceptable salt or solvat...
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WO/2012/010575A1 |
The invention relates to (4-halogenalkyl-3-thiobenzoyl)cyclohexanediones of general formula (I) and to the use thereof as herbicides. In said formula (I), X, Y, R1, R2, R3 and R4 represent radicals such as hydrogen and organic radicals s...
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WO/2012/010574A1 |
The invention relates to (4-trifluormethyl-3-thiobenzoyl)cyclohexanediones of general formula (I) and use thereof as herbicides. In said formula (I) X, R1, R2, R3 and R4 represent radicals such as hydrogen and organic radicals such as al...
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WO/2012/010644A1 |
Process for the synthesis of an isothiocyanate of general formula (I) SCN‑R1-R4-R2 in which R1 and R2 represent, independently of one another, an alkyl, aryl or alkylaryl group, R4 represents a carbonyl, sulphinyl or sulphonyl group or...
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WO/2012/005691A1 |
The present invention generally relates to processes and methods of peptide and protein synthesis. The present invention also relates to specific compounds for use in such processes and methods. It is shown herein that peptides with a C-...
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WO/2011/161101A1 |
The invention relates to selective estrogen receptor modulators (SERMs) and to processes for production thereof, to the use thereof for treatment and/or prophylaxis of disorders, and to the use thereof for production of medicaments for t...
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WO/2011/159840A2 |
Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of dis...
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WO/2011/157959A1 |
The invention relates to a process for preparing acrolein from glycerol or glycerin, according to which glycerol or glycerin is dehydrated in the presence of a catalyst, the active phase of which consists of at least a) a silicon oxide, ...
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WO/2011/152782A1 |
The present invention relates to dimeric pentadentate chelators with exceptionally strong binding of metal ions, for detection, immobilization and purification of biomolecules. Dimeric chelators offer a cooperativity of binding of two ad...
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WO/2011/152540A1 |
The present invention relates to a process for producing methionine, comprising a first step of reacting 2-amino-3-buten-1-ol with methanethiol, and a second step of oxidizing 2-amino-4-methylthio-1-butanol obtained in the first step. Th...
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WO/2011/146954A1 |
Process for the preparation of a Compound of formula I in the form of a single stereoisomer in crystalline form, comprising deprotecting the amine group in a Compound of formula IIa or in a mixture of a compound of formula IIa With a com...
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WO/2011/038385A9 |
Sulfur-containing ligands and methods of their utilization for binding metals and/or main group elements and removing them from fluids, solids, gases and/or tissues are disclosed. The ligands are of the general structure (A): or structur...
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WO/2011/141568A1 |
The present invention provides a method for the preparation of a radiolabeiied guanidine derivative, in particular wherein the radiolabeiied guanidine derivative is a positron emission tomography (PET) tracer. Certain intermediates usefu...
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WO/2011/139887A2 |
The present invention provides bis(hydroxyalkyl)mercaptosuccinates of the formula: (I) and derivatives thereof, where X1, X2, Z1, Z2, Y1, Y2, Ra, Rb, R1, and R2 are those defined herein. The present invention also provides methods for pr...
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WO/2011/132171A1 |
The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups ...
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WO/2011/132712A1 |
Provided is a novel compound that is useful as a medical drug in that said compound displays strong antimicrobial activity against gram-negative bacteria such as Pseudomonas aeruginosa and drug-resistant strains thereof, on the basis of ...
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WO/2011/130170A1 |
The present invention discloses compositions comprising oligomers derived from bis(beta-hydroxy) polysulfides, such as dihydroxydiethyl disulfide, and oligomerization processes for producing these compositions.
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WO/2011/126129A1 |
The present invention relates to a process for producing a sulfur-containing amino acid, comprising a step of oxidizing a 2-aminoethanol compound having, at position 2, a sulfur-containing hydrocarbon group having 1 to 24 carbon atoms in...
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WO/2011/126130A1 |
The present invention relates to a process for producing a sulfur-containing amino acid, comprising a step of oxidizing a 2-aminoethanol compound having, at position 2, a sulfur-containing hydrocarbon group having 1 to 24 carbon atoms in...
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WO/2011/122507A1 |
An ester compound represented by formula (1): wherein R1 represents hydrogen, fluorine, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkoxymethyl, or C1-C4 alkylthiomethyl; R3 represents hydrogen or methyl, R4 represents hydrogen or C1-C4 alkyl, and...
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WO/2011/118849A1 |
According to the present invention, a new process for producing a sulfur-containing amino acid without using of hydrogen cyanide or sodium azide which requires careful handling as a raw material can be provided. The present invention rel...
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WO/2011/119272A2 |
Macr-photoinitiators having defined polymer chain structure are provided. The macro-photoinitiators are terminated with residues of thiol and/or hydroxyl functional photoinitiators. The macro-photoinitiators may be prepared by controlled...
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WO/2011/119759A1 |
The invention provides a novel class of compounds viz. generally lipopeptides like Pam3CSK4, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent disea...
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WO/2011/118339A1 |
Disclosed is a complex comprising a thioether-containing organic compound represented by formula: X(OCH2CHR1)nOCH2CH(OH)CH2SZ [wherein X represents an alkyl group; R1 represents a hydrogen atom or a methyl group; n represents an integer ...
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WO/2011/114792A1 |
Disclosed are a dispersion of fine particles of a substituted benzenedithiol metal complex, which is maintained in a stable dispersion state without reaggregation for a long period of time, has long-lasting excellent light resistance, an...
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WO/2011/113774A1 |
The invention related to a process for the preparation of a bismercaptodiether by reacting a polysulfide with a monothiol in the presence of a base and to a process for the depolymerization of a polysulfide by reacting said polysulfide w...
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WO/2011/114955A1 |
Disclosed are: a diaryl sulfone compound represented by general formula (1); a manufacturing method for a diaryl sulfone compound represented by general formula (1) in which a 4,4'-dihalo aryl sulfone compound is reacted with a thiol sal...
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WO/2011/112535A2 |
The invention relates to propionic acids, propionic acid esters, and related compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds for the treatment of various diseases or conditions, inc...
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WO/2011/107877A2 |
A compound, composition and method of making and using a compound of formula (1) are disclosed. The compound of formula I also comprises of salts, polymorphs, solvates, mesylates, hydrochloric salt, solvates and hydrates thereof. The com...
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WO/2011/105524A1 |
An ester compound represented by formula (1): wherein R1 represents hydrogen, fluorine, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkoxymethyl, or C1-C4 alkylthiomethyl; and R2 represents C1-C4 alkyl, has an excellent pest control effect and is t...
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