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JP2012513445A |
Chiral compounds of the formula (1), which are optically pure or highly optically enriched in which R 0 is C 1 -C 12 -alkyl which is unsubstituted or substituted by 1 to 2 C 1 -C 4 -alkoxy; cyclopentyl or cyclohexyl, which is unsubstitut...
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JP2012513481A |
The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-±) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I)-(VIII) and by Compounds (I)-(I),...
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JP2012111717A |
To provide a method for obtaining a compound containing a dichloromethyl group from a compound containing a trichloromethyl group, capable of efficiently eliminating chlorine by cutting one carbon-chlorine bond in the trichloromethyl gro...
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JP4948030B2 |
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JP4947996B2 |
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JP2012512263A |
The invention relates to a catalytic method for the industrial production of a diol compound, such as 2-methyl-2-4-pentanediol, also called 2,4-hexylene glycol (HGL), from a beta-hydroxy carbonyl compound, Formula (I), in particular diac...
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JP4935763B2 |
There are provided a fluorine-containing ethylenic monomer having hydroxyl group or fluoroalkyl carbonyl group and represented by the formula (1): and the formula ( 14): respectively, wherein X<1> and X<2> are the same or different and e...
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JP2012510953A |
The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reduci...
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JP2012087138A |
To provide a hydrogenation method useful for the hydrogenation of substrates having a carbon-hetero atom double bond.The catalysts of formula (II): [Ru(L)m(L')wXY] are used to reduce a compound having the carbon-hetero atom double bond b...
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JP4928798B2 |
Compounds represented by the following general formula (1a) or (1b). A complex comprising a center metal of rhodium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for optically active bet...
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JP2012082142A |
To provide a practical method for preparing a benzene carbinol derivative.The method for preparing the benzene carbinol derivative represented by a corresponding structure comprises carrying out an oxidation reaction of an α,α-alkyl-su...
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JP4919562B2 |
trans-RuH(eta<1>-BH4)[(S)-xylbinap][(S,S)-dpen] (0.00125 mmol), acetophenone (5.0 mmol), and 2-propanol (2.5 mL) were placed in an autoclave, and the resulting solution was repeatedly subject 5 times to a procedure of performing pressure...
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JP4910186B2 |
A cyclopentadienyl ruthenium (II) complex or (iv) complex having an ±-imino acid type ligand or an ±-amino acid type ligand.
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JP2012055882A |
To prevent the aging deterioration of catalyst activity caused by the melt-out of an active metal of an oxidation catalyst composed of an alloy carrying material.The alloy carrying material is formed in such a manner that alloy particles...
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JP4902840B2 |
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JP4892195B2 |
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JP4892808B2 |
A process for the production of a fluorinated organic compound, characterized by fluorinating an organic compound having a hydrogen atoms using IF5; and a novel fluorination process for fluorinating an organic compound having a hydrogen ...
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JP4890258B2 |
A new method for preparing lithium phosphate catalysts is disclosed. The method comprises precipitating a lithium phosphate from a mixture comprising a first aqueous solution which contains lithium and sodium ions and a second aqueous so...
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JP4884656B2 |
Pyran compounds having exocyclic double bonds are new. Pyran compounds of formula (I) having exocyclic double bonds are new. [Image] a-e : 0 or 1; W : -CH 2- or -C(=O)-; R 11>H, 1-15 C alkyl optionally substituted by halo or CN and optio...
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JP4887720B2 |
A fluorine-containing benzaldehyde is reacted with an alkyl Grignard reagent to convert it to a magnesium alkoxide of racemic, fluorine-containing, benzyl alcohol, and subsequently the magnesium alkoxide is reacted with phthalic anhydrid...
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JP4885389B2 |
A silicone composition prepared by mixing (A) 100 parts by weight of an organopolysiloxane containing an average of at least two silicon-bonded alkenyl groups per molecule, (B) an organohydrogenpolysiloxane containing an average of at le...
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JP2012504596A |
The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of specific ruthenium catalysts or pre-catalysts in hydrogenation processes for the reduction of ketones, aldehydes, esters or lacto...
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JPWO2010032712A1 |
In the present invention, in a microreactor having a reaction liquid introduction port, a reaction liquid flow path, and a reaction liquid discharge port, the thin film forms a surface acoustic wave, and the thin film forms a surface aco...
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JP4873206B2 |
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JP2012020977A |
To provide a new method of organic reaction carrying out a carbon-carbon bond-forming reaction or the like without using an organic solvent which has daily been utilized in an organic synthesis at all.The organic reaction is carried out ...
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JP4867904B2 |
A conductive pattern formation ink capable of forming a conductive pattern having high reliability, a conductive pattern having high reliability, a method of forming a conductive pattern having high reliability, and a wiring substrate pr...
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JP4867905B2 |
A conductive pattern formation ink which can be stably ejected in the form of liquid droplets and form a conductive pattern having high reliability, a conductive pattern having high reliability, and a wiring substrate provided with the c...
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JP4864252B2 |
To provide a composition manifesting an excellent effect by using a compound or a fraction having excellent anti-inflammatory effect obtained from vegetables which have been used in traditional medical treatment. This composition manifes...
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JP2012502124A |
Polymer obtainable by polycondensation or polyadduct formation from monomeric compounds, wherein accompanying use is made as monomeric compound of substituted 2-aryl-2-alkyl-1,3-propanediols of the formula I or substituted 2-cyclohexyl-2...
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JP4862162B2 |
Provided are a hydrogenation catalyst for carbonyl groups which can produce an unsaturated alcohol by hydrogenating an unsaturated carbonyl compound with high selectivity by a simple process at low cost, a method of efficiently producing...
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JP4859461B2 |
The present invention provides an industrially safe, easily operable process for producing an optically active epoxy alcohol derivative useful as an intermediate for pharmaceuticals from inexpensively available materials, and also provid...
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JP4857676B2 |
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JP4855368B2 |
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases m...
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JP4853757B2 |
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JP4844969B2 |
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JP4841954B2 |
The invention relates to a phosphonium borate compound represented by Formula (I) (hereinafter, the compound (I)). The invention has objects of providing (A) a novel process whereby the compound is produced safely on an industrial scale,...
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JP2011246412A |
To provide a ruthenium complex utilizable as a reduction catalyst of an organic compound by utilizing water as a hydrogen source.The ruthenium complex is represented by formula (11) or (12).
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JP2011241191A |
To provide a method for producing an optically active alcohol in high yield with high enantio-selectivity from a ketone compound.The method for producing an optically active alcohol includes a step of allowing a ketone compound to react ...
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JP4825969B2 |
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JP4824740B2 |
The present invention is related to novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of formula (I) wherein W represents -C(=O)- or -CH(OH)-; R 1 represents hydrogen o...
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JP2011236165A |
To provide a method for producing alkene for allowing production of a target compound under a mild condition in excellent yield when producing the corresponding alkene by deoxidation of an epoxy compound.In the method for producing alken...
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JP4821459B2 |
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JP2011231048A |
To provide a method of manufacturing an α-aryl alcohol by making an alkyl aryl ketone to be hydrogenated industrially advantageously.The environmental harmony type production method of an α-aryl alcohol comprises as follows. In a hydro...
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JP4815984B2 |
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JP4815926B2 |
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JP4802521B2 |
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JP4796303B2 |
The present invention relates to processes for preparing peptides and to intermediates involved in such processes, e.g. a process for preparing a compound of formula VIII wherein R12 and R13 are as defined herein.
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JP4786804B2 |
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JP4780959B2 |
A process for the manufacture of an acetylenically unsaturated alcohol comprising reacting formaldehyde, an aldehyde or a ketone (a carbonyl compound) with acetylene in the presence of ammonia and an alkali metal hydroxide, the molar rat...
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JP4779294B2 |
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