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JPH024215B2 |
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JPH0222226A |
PURPOSE: To obtain the title remedy effective for treating osteopathic disease such as osteoporosis containing a PGD analog compound such as PGD2 or 12-PGJ2 or PGD1 as an active ingredient. CONSTITUTION: A remedy for osteropathic disease...
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JPH02167A |
NEW MATERIAL:5-Thia-Δ7-prostaglandin Es expressed by formula I [R1 is H or 1-10C alkyl; R2 is (substituted) 1-10C alkyl or (substituted) cycloalkyl; R3 and R4 are H or protecting group; indication of formula II denotes 7Z, 7E isomer or ...
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JPH0159256B2 |
NEW MATERIAL:The compound of formula I and formula II (A is O, H or OH; B is -CH=CH- or -C C-; R<1>-R<3> are H or 1-4C alkyl; R<4> is H, OH or protected hydroxyl group; R<5> is 1-10C (substituted) hydrocarbon group; R<6> is H, 1-6C alkyl...
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JPH0159255B2 |
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JPH0149264B2 |
A novel prostaglandin analogue of the formula:(wherein the symbol ◄ represents β-configuration, the dotted linie ----- represents a-configuration, and the double bond between (C13-C14 represents transconfiguration) and cyclodextrin cl...
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JPH0149127B2 |
Stable compositions of PGE-type compounds are achieved by dissolving those compounds in carbonate diester solvents which may contain water up to the solubility limit of the carbonate diester.
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JPH0148266B2 |
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JPH0148256B2 |
A process for preparing a 3-oxo-7-hydroxy-bicyclo[3,3,0]octan-2-ylcarboxylic acid ester of the formula wherein R1 is alkyl of 1-6 carbon atoms or phenalkyl of 7-10 carbon atoms and R2 is hydrogen, alkyl or 1-6 carbon atoms, phenalkyl of ...
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JPH0146499B2 |
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JPH0144699B2 |
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JPH0144172B2 |
An E-type prostaglandin in a solvent comprising a mixture of triacetin and ethanol, which has good stability and is rapidly miscible with water.
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JPH01502750A |
PCT No. PCT/DE88/00151 Sec. 371 Date Nov. 23, 1988 Sec. 102(e) Date Nov. 23, 1988 PCT Filed Mar. 11, 1988 PCT Pub. No. WO88/07037 PCT Pub. Date Sep. 22, 1988.The invention relates to 6-oxo-prostaglandin E1 derivatives of formula I, (I) i...
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JPH0142938B2 |
A novel 13-aza-14-oxo-TXA2 analogue of general formula:[wherein symbol A represents(i) a group of general formula: -CH2CH2-(CH2)m-,(ii)) a group of general formula: cis-CH=CH-(CH2)17,(iii) a group of general formula: -CH2O-(CH2)m-,(iv) a...
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JPH0141625B2 |
The present invention is directed to new 16-methoxy-16-methyl prostaglandin E1 derivatives of the following general formula wherein R stands for a (C1-4) alkyl group or a non-toxic pharmaceutically acceptable cation, to a process for pre...
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JPH0141139B2 |
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JPH0141147B2 |
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JPH0141144B2 |
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JPH0141146B2 |
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JPH0141145B2 |
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JPH0141140B2 |
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JPH0141142B2 |
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JPH0141143B2 |
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JPH0140824B2 |
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JPH0140825B2 |
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JPH0140813B2 |
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JPH0140021B2 |
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JPH0140020B2 |
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JPH0138104B2 |
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JPH01502117A |
Therapeutical compositions containing products obtained from the addition of thiols to prostaglandines or analogues of prostaglandines. These compositions have an antitumoral activity.
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JPH0129168B2 |
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JPH01501360A |
Process for the manufacture of (-)-oxabicyclo[3.3.0]octanolones of formula (-)-I, where R is hydrogen or the residue (a), in which R1 has the notation of a hydrogen, alkyl with 1-7 C atoms, or phenyl. The process is characterized in that...
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JPH01501281A |
PCT No. PCT/DE87/00517 Sec. 371 Date Jul. 13, 1988 Sec. 102(e) Date Jul. 13, 1988 PCT Filed Nov. 12, 1987 PCT Pub. No. WO88/03568 PCT Pub. Date May 19, 1988.A microbiological process for sterospecific monoketo reduction of racemic 3-keto...
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JPH0123445B2 |
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JPH01110644A |
NEW MATERIAL:A compound shown by formula I (R1 is H, alkyl, aralkyl, cycloalkyl, phenyl or 1 equivalent cation; X is O-CH2 or CH2-O; B is trans CH=CH or C≡C; R2 is alkyl, aryloxy, cycloalkyl, alkenyl or phenyl; R1 is H, methyl or vinyl...
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JPH01501229A |
PCT No. PCT/DE87/00515 Sec. 371 Date Jul. 13, 1988 Sec. 102(e) Date Jul. 13, 1988 PCT Filed Nov. 12, 1987 PCT Pub. No. WO88/03526 PCT Pub. Date May 19, 1988.The invention relates to a process for manufacturing optically active carbacycli...
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JPH01102059A |
NEW MATERIAL:A compound of formula I (A is carbonyl, hydroxymethylene; R1 is 1W10C alkyl, 5W6-membered cycloalkyl; R2 is H, 1W10C alkyl; R3, R4 and H, protecting group; R5 is H, hydroxy; broken lines means single or double bonds) and its...
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JPH0115517B2 |
Compounds of the formula wherein R is phenyl cyclohexyl or lower alkyl containing 1-6 carbon atoms; R'' is hydrogen or methyl; R''' is alkenyl or alkynyl having 3-5 carbon atoms; R' is hydrogen, tetrahydrofuran-2-yl tetrahydropyran-2-yl ...
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JPH0114910B2 |
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JPS6411620B2 |
Novel 7-hydroxyprostaglandins E1, or stereoisomers thereof, or protected derivatives thereof, having the following formula: …… wherein R<8> represents H, CH3 or C2H5, R<9> represents H or CH3, R<1><0> and R<1><1> are identical or dif...
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JPS6411018B2 |
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JPS646181B2 |
This disclosure describes novel 2,5-dihydro-2,5-dialkoxyfuran derivatives useful as intermediates for the preparation of the natural prostaglandins and their congeners.
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JPS6366832B2 |
4,5-Unsaturated 16-hydroxy prostanoic acid derivatives displaying valuable pharmacological properties, e.g. gastric antisecretory, are described herein.
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JPS63287747A |
The present invention relates to allenic prostacyclin derivatives of the formula: wherein: n is 0, 1,2 R<1> is hydrogen, lower alkyl, lower hydroxyalkyl, or a pharmaceutically acceptable cation; R<2> is hydrogen, lower alkyl, cycloalkyl,...
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JPS63287751A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS63246331A |
Prostaglandin E1 derivatives as pharmacological active compounds and medicaments containing these compounds are described, in particular for transcutaneous application.
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JPS6344743B2 |
An improved method for the preparation of prostaglandin analogs which comprises preparation of two equivalents of an alkyl or alkenyl lithium reagent in an aprotic solvent mixture such as pentane or hexane and tetrahydrofuran, conversion...
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JPS6344143B2 |
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JPS6343385B2 |
PCT No. PCT/JP84/00294 Sec. 371 Date Jun. 11, 1985 Sec. 102(e) Date Jun. 11, 1985 PCT Filed Jun. 7, 1984 PCT Pub. No. WO84/04917 PCT Pub. Date Dec. 20, 1984.7-Fluoroprostaglandins represented by the following formula (I): (I) In the form...
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JPS63502184A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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