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JPS6341909B2 |
This disclosure describes novel derivatives of alpha -(6-carboxyhexyl) furfuryl alcohol which are useful as intermediates for the preparation of natural prostaglandins and their congeners.
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JPS63501871A |
Carbacycline derivatives of general formula (I), in which Y1 is the residue of Formula (II), R9 is the residue -(CH2)m-R6 or the residue -(CH2)m-o-[Z1-(CH2)m-p]x-[Z2-(CH2)m-q]y-R6, m = 2-20; o, p and q <= 19; x, y = 0, 1 or 2; Z1 is a ci...
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JPS63174938A |
PURPOSE: To obtain the titled substance contained as a partial structure of prostaglandins in high stereoselectivity and yield, by reacting an optically active alcohol and water with lithium aluminum hydride and reducing an enone using t...
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JPS63139144A |
This disclosure describes novel compounds which are useful as precursors in the synthesis of 9-oxo-11 alpha , 16-dihydroxy-16-vinyl-5-cis-13-trans-prostadienoate esters which possess activity as hypotensive agents and/or as vasodilators.
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JPS63122665A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS63122663A |
Compounds of the general formula (1) in which n is 1 or 2; m is 2-5 and X is -CH=CH- or -CH2-CH2-; or m is 1-4 and X is -CH=C=CH-; R<1> is phenyl, substituted phenyl or naphthyl; Y is substituted or unsubstituted 3-phenoxy-2-hydroxypropy...
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JPS63122664A |
Compounds are described of formula wherein n is 1 or 2; m is 2-5 and X is -CH=CH- or -CH2-CH2-; or m is 1-4 and X is -CH=C=CH-; Z is -CH2OH, -CHO or -CONHR<1> [where R<1> is a hydrogen atom or C1-4 alkyl, aryl, -COR<2> (where R<2> is a h...
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JPS6321660B2 |
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JPS6377821A |
PURPOSE: To obtain prostaglandin E composition useful as a hypotensor, antiulcer, antithrombotic agent, utero-evacuant agent or odynopoeia agent, by blending prostaglandin E with polyvinyl pyrrolidone. CONSTITUTION: Prostaglandin E is bl...
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JPS6372672A |
NEW MATERIAL:A compound expressed by formula I (R1 is 1W10C alkyl; R2 is alkyl or alkenyl; R3 is H, tri 1W7C hydrocarbon silyl or group capable of forming a acetal bond with O of group; A and B are respectively H and OH or one bonding ha...
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JPS6312051B2 |
Compounds of the formula wherein R1 is (a) hydrogen, (b) C1-10 alkyl, (c) C1-10 alkyl substituted by halogen; C1-4 alkoxy; C6-10 aryl; C6-10 aryl substituted by 1-3 halogen atoms, a phenyl group, 1-3 C1-4 alkyl groups or a chloromethyl, ...
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JPS6348230A |
PURPOSE: To obtain the titled compound useful as an intermediate for various fluorine-containing physiologically active compounds which have been hardly synthesized in the past in one stage, by fluorinating a β-ketocarboxylic acid deriv...
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JPS632972A |
NEW MATERIAL:A compound shown by formula I (R is H or lower alkyl; R1 is 5W7C alkyl; broken line is alpha steric configuration of bond between stoms, wedge line is beta steric configuration of bond between stoms and wavy line is alpha of...
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JPS6261593B2 |
The present invention relates to thienyl-prostaglandin derivatives and to a process for their manufacture. The compounds according to the invention have valuable pharmaceutical properties.
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JPS6261592B2 |
The present invention relates to thienyl-prostaglandin derivatives and to a process for their manufacture. The compounds according to the invention have valuable pharmaceutical properties.
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JPS6259700B2 |
Prostane derivatives of the formula I wherein R1 is OR2 or NHR3; R2 is hydrogen, C1-10 alkyl, C4-10 cycloalkyl, C6-10 aryl, or a 5 or 6 membered heterocyclic ring having 1-3 hetero atoms selected from O, N and S; R3 is the residue of a h...
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JPS62277352A |
NEW MATERIAL:A compound of formula I [R1 is amino acid residue; R2 is single bond or 1W4C alkylene; R3 is 1W8C alkyl, 4-7C cycloalkyl which may be substituted with 1W8C alkyl or phenyl or phenoxy which may be substituted with Cl, CF3 or ...
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JPS6254789B2 |
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JPS6252745B2 |
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JPS6248668B2 |
Prostane derivatives of the formula wherein R1 is (a) hydrogen, (b) C1-10 alkyl, (c) C1-10 alkyl substituted by halogen; C1-4 alkoxy; C6-10 aryl; C6-10 aryl substituted by 1-3 halogen atoms, a phenyl group, 1-3 C1-4 alkyl groups or a chl...
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JPS62234060A |
NEW MATERIAL:A compound expressed by formula I (R1WR3 are lower alkyl). EXAMPLE: Methyl (5S,6R)-5,6-diacetoxy-(7E)-7[(2S)-2-hydroxy-2-n-octyl-4-chlo
ro-5- oxo-3-cyclopentene-1-ylidene]heptanoate. USE: An anticancer agent. PREPARATION: A ...
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JPS6247869B2 |
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JPS6244533B2 |
A novel 3-endo-protected hydroxyl-tricyclo[3,2,0,02,7]heptan-6-one is described which can be alkylated stereospecifically to give a 5-endo-protected hydroxyl-bicyclo[2,2,1]heptan-2-one which may then be converted via a sequence of reacti...
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JPS62201817A |
PURPOSE: The titled composition useful as an inhibitor of blood platelet aggregation, hypotensor, etc., having extremely improved stability, by adding a preservative and/or an antioxidant to a solution of a 15-deoxy-16-hydroxyprostagland...
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JPS62201842A |
This disclosure describes novel derivatives of alpha -(6-carboxyhexyl) furfuryl alcohol which are useful as intermediates for the preparation of natural prostaglandins and their congeners.
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JPS6241207B2 |
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JPS6236012B2 |
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JPS62153259A |
NEW MATERIAL:A compound expressed by formula I [R1 is -CH2CH2CH2CH2 COOR5, -CH2CH2-O-CH2COOR5, etc., (R5 is H or 1W6C alkyl); R2 is H, 1W7C acyl, etc.; R3 is 3W10C alkyl, 3W12C alkenyl, etc.]. EXAMPLE: 3-(4-Ethoxycarbonyl-1-butynyl)-6-ex...
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JPS6228788B2 |
Prostaglandin I2 analogues of the formula: II [wherein R1 represents hydrogen, alkyl of 1 to 12 carbon atoms, aralkyl of 7 to 12 carbon atoms, cycloalkyl of 4 to 7 carbon atoms optionally substituted by alkyl of 1 to 4 carbon atoms, phen...
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JPS6228937B2 |
Carbacyclin derivatives of Formula I (I) wherein R1 is OR2, wherein R2 is hydrogen, alkyl, cycloalkyl, aryl, a heterocyclic residue, or NHR3, wherein R3 is an acid residue or hydrogen; X is oxygen; A is -CH2-CH2-, trans-CH=CH-, or -C 3BO...
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JPS62501500A |
Compounds having thromboxane antagonist activity are of use in the treatment of hormone-dependent neoplasias, for example oestrogen-dependent neoplasias.
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JPS6228140B2 |
Aldol derivatives of the formula, …… wherein C = W is a carbonyl group or a protected carbonyl group are intermediates for producing methanoprostacyclin derivatives which are useful medicines for prevention of thrombosis. Such a comp...
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JPS6228134B2 |
Prostaglandin I2 analogues of the general formula [wherein R1 represents a hydrogen atom, an alkyl group containing from 1 to 12 carbon atoms, an aralkyl group containing from 7 to 13 carbon atoms, a cycloalkyl group containing from 4 to...
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JPS6225141B2 |
13-Thiaprostanoic acid derivatives of the general formula I (I) wherein A is -CO- or -CHOH-; B is -CH2CH2- or -CH=CH-; Q is 1,4-phenylene or 1,4-naphthylene; R1 is H or OH; R2 is H or CH3; R3 is alkyl with 1-8 carbon atoms or alkyl with ...
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JPS6224422B2 |
Compounds of the formula wherein the 9-chlorine atom can be in the alpha - or beta -position, R1 is OR2, or NHR3 wherein R3 is H or the acyl group of a C1-15 hydrocarbon carboxylic or sulfonic acid; A is -CH2-CH2- or cis-CH=CH-, B is -CH...
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JPS62103061A |
PURPOSE: To obtain the titled compound useful as pharmaceuticals from an easily available raw material in short steps and high yield, by selectively reducing the 7,8-double bond of a 16-substituted-Δ7-prostaglandin E compound. CONSTITUT...
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JPS6220989B2 |
Stabilized prostacyclins having a wide range of pharmacological activity and long duration of such activity, have the formula wherein R1 is (a) OR3, wherein R3 is hydrogen, alkyl, cycloalkyl, aryl or a heterocyclic residue; or (b) NHR4 w...
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JPS6218548B2 |
Procedure for the preparation of new cyclopentane derivatives of the formula I *** see image 01 in which R1 and R2 together signify oxygen or in each case hydrogen or a hydroxyl group, R1 and R2 being different; R3 means hydrogen or a st...
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JPS6216929B2 |
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JPS6259258A |
NEW MATERIAL:The compound of formula I (R1 is 1W10C alkyl; R2 is OH- protecting group or H; A is H and B is OH or A and B together form a bond; *represents optically active or inactive C atom). USE: A carcinostatic agent and antiviral ag...
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JPS6256469A |
This invention relates to novel acetylenic prostaglandin derivatives of the following structural formula: wherein R is hydrogen; or straight or branched chain alkyl of 1 to 6 carbon atoms; R1 is hydrogen; or straight or branched chain al...
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JPS6210226B2 |
The present invention provides novel prostaglandin analogs wherein the C-2 carboxyl is replaced by alkylcarbonyl, i.e., a C-2 ketone. These novel 2-decarboxy-2-alkylcarbonyl-PG-type compounds are disclosed as improved gastrointestinal cy...
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JPS6210227B2 |
Novel 16-phenoxy and 16-(o, m or p)-substituted phenoxy derivatives of (dl)-9-keto-11 alpha ,15 alpha -dihydroxy-17,18,19,20-tetranorprosta-4,5,13-trans-trienoic acid, the pharmaceutically acceptable, non-toxic lower alkyl esters and sal...
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JPS6210218B2 |
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JPS6210233B2 |
The present invention relates to thienyl-prostaglandin derivatives and to a process for their manufacture. The compounds according to the invention have valuable pharmaceutical properties.
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JPS6229568A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS625904B2 |
What is disclosed are prostaglandin-analogous cyclopentane derivatives of the formula I wherein R1 is hydrogen or a linear or branched, saturated or unsaturated aliphatic or cycloaliphatic radical having from 1 to 8 carbon atoms, or an a...
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JPS624390B2 |
Prostanoic acid derivatives of the formula wherein R1 is a hydrogen atom, alkyl of 1-10 carbon atoms, aryl or -CH2-U-V wherein U is a direct bond, carbonyl, or carbonyloxy and V is phenyl or substituted phenyl, e.g. substituted by at lea...
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JPS62887B2 |
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JPS62999B2 |
The invention concerns a new process for the preparation of 5-halo-6,9 alpha -oxido-prostaglandin derivatives of the general formula II (II) wherein R1 represents a hydrogen atom, an alkyl group optionally substituted by aryl, amino, hyd...
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