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WO/2014/202597A1 |
Disclosed is a compound having the formula a) or b); a: R = CH3; b: R = CH2CH3, and its use in the prevention and/or treatment of Alzheimer's disease.
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WO/2014/195327A1 |
The present invention relates to a compound of formula (I): wherein: R8 and R9, independently of each other, are hydrogen, fluorine or C1-C3alkyl; R10 is hydrogen or methyl (preferably hydrogen); and the other substituents are as defined...
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WO/2014/197514A1 |
The present disclosure generally relates to the production of fuels, gasoline additives, and/or lubricants, and precursors thereof. The compounds used to produce the fuels, gasoline additives, and/or lubricants, and precursors thereof ma...
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WO/2014/191535A1 |
The present invention relates to a compound of formula (I): wherein: X is methyl or chlorine; R1 is fluorine or bromine; R2 is ethynyl, C1-C3alkoxy, C1-C3haloalkoxy, or C1-C3alkoxy-C1-C3alkoxy-; and Q is a pyran-3,5-dione-4-yl, a thiopyr...
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WO/2014/191256A1 |
The invention relates to a method for producing photo-cleavable fragrance pre-cursors, to agents containing said fragrance pre-cursors and to the use of the fragrance pre-cursors for prolonging the fragrant effect in the agent and on sur...
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WO/2014/191534A1 |
The present invention relates to a compound of formula (I): wherein: X is methyl or chlorine; R1 is fluorine or bromine; R2 is ethynyl, C1-C3alkoxy, C1-C3haloalkoxy, or C1-C3alkoxy-C1-C3alkoxy-; and Q is a pyran-3,5-dione-4-yl, a thiopyr...
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WO/2014/191187A1 |
The present invention concerns compounds of formula (I) in the form of any one of its stereoisomers or a mixture thereof, and wherein each R, independently from each other, represents a hydrogen atom or a methyl or ethyl group provided t...
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WO/2014/191457A1 |
The present invention relates generally to methods of synthesis of diterpene heterocylic compounds. More particularly, the present invention relates to efficient methods of synthesis of ingenol (Formula (21), CAS 30220-46-3), from a comp...
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WO/2014/193837A1 |
The present disclosure provides methods of preparing glucagon-like peptide-1 (GLP-1) receptor modulators, such as compounds of Formula (II) or (VI), or intermediates thereof. The compounds that may be prepared by the described methods ar...
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WO/2014/190276A1 |
A cleaner composition with improved cleaning of hydrophobic contaminants typically found on used brake assemblies and parts, including one or more low vapor pressure hydrocarbon solvents, one or more exempted volatile organic compounds, ...
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WO/2014/189623A1 |
In a process for producing phenol and cyclohexanone, reaction components comprising cyclohexylbenzene hydroperoxide and an acid catalyst are supplied to a cleavage reaction zone, mixed under mixing conditions effective to combine the rea...
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WO/2014/184416A1 |
The invention relates to the synthesis and use of compounds comprising squaramide for the treatment of diseases of parasitic origin, such as American trypanosomiasis also known as Chagas disease, or leishmaniasis.
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WO/2014/185561A1 |
The present invention relates to a pharmaceutical composition for preventing or treating diseases associated with UCH-L1, containing an UCH-L1 inhibitor compound and a pharmaceutically acceptable salt thereof as active ingredients. The c...
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WO/2014/177593A1 |
The present invention relates to Amorfrutin analogues and stereoisomeric forms, solvates, hydrates, conjugates and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of ...
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WO/2014/175670A1 |
The present invention relates to a method for synthesizing acetophenone by selective oxidation of ethylbenzene. According to the present invention, provided is a method enabling mass synthesis of acetophenone in a higher yield through a ...
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WO/2014/170422A1 |
The present invention concerns a method of oxidizing a cycloalkane to form a product mixture containing a corresponding alcohol and ketone, said method comprising contacting a cycloalkane with an oxidant agent in the presence of catalyti...
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WO/2014/170915A1 |
Disclosed herein are the novel insect repellents of formula (I) to control the spread of various tropical diseases and to the process of preparation thereof wherein R, Rl, R3, R4 represents hydrogen or alkyl; R2 is selected from hydrogen...
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WO/2014/167481A1 |
The present invention relates to novel synthetic analogues of xanthohumol and the use thereof.
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WO/2014/168056A1 |
According to the present invention, a hydrate of 1,1,1,5,5,5-hexafluoroacetylaceton can be produced by a method comprising: a first step of reacting a 3,3,3-trifluoropropenyl metal with a trifluoroacetate ester to produce a reaction mixt...
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WO/2014/165633A1 |
The present invention is directed to compounds of formula I: wherein A is n is 0, 1, or 2; m is 0 or 1; R1 is H or C1-6alkyl and R2 is H, C1-6alkyl, C1-6alkaryl, aryl, or heteroaryl; and X is O or NH. Tautomers, enantiomers, and diastere...
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WO/2014/163643A1 |
This invention relates to geranylgeranyl acetone (GGA) derivatives and the use of GGA, its isomers, and GGA derivatives in methods for inhibiting neural death, increasing neural activity, increasing axon growth and cell viability, and in...
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WO/2014/163080A1 |
The purpose of the present invention is to provide a method for producing a cyclohexanone compound, e.g., cyclohexanone, in an economically advantageous manner and with high efficiency. The method for producing a cyclohexanone compound a...
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WO/2014/165339A1 |
A process for producing phenol and/or cyclohexanone by cleaving cyclohexylbenzene hydroperoxide in a loop cleavage reactor comprising multiple reaction zones connected in series. In desirable embodiments, fresh cyclohexylbenzene hydroper...
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WO/2014/165424A1 |
The present invention provides a process for preparing C10 to C30 alcohols, comprising the following steps: (i) reacting aliphatic, non-cyclic C10 to C30 olefins with N2O to obtain an oxidation reaction product comprising a C10 to C30 ca...
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WO/2014/165861A1 |
The coupling of aryl, heteroaryl, and vinyl halides with α,α-difluoroketones or silyl ethers or siylenol ethers of α,α-difluoroketones and α,α-difluoroamides and esters are described. Further derivatization of the coupling products...
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WO/2014/158242A1 |
The invention provides a method of treating, inhibiting and/or preventing fatty liver disease in a patient in need thereof, comprising administering an effective amount of a cyclohexenone compound of the following formula (I) to said pat...
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WO/2014/159508A1 |
The present disclosure provides methods for separating ketones and alcohols. In one embodiment, the methods and compositions disclosed are useful in separating cyclohexanol from cyclohexanone. In one embodiment, cyclohexanone is converte...
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WO/2014/156360A1 |
[Problem] To provide: a method for producing a novel acetophenone compound, which enables the production of an acetophenone compound, which is a compound that can be used as an intermediate raw material for the production of various biol...
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WO/2014/152850A1 |
A method of preparing a polymer is provided comprising preparing a Baylis-Hillman adduct by reacting an activated alkene with a carbon electrophile; and polymerizing the Baylis-Hillman adduct. The Baylis-Hillman reaction provides an effi...
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WO/2014/152366A1 |
Catalysts, methods and systems are provided for the production of primary alcohols, secondary alcohols, ketones, aldehydes, alkanes, alkenes, 1,ω-diols, cyclic ethers and lactones with utility as commodity chemicals, using furfural or h...
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WO/2014/151181A1 |
A process for the synthesis of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3
,4b,7,8,8a,9,10,10a-octahydrophenanthrene-2,6-dicarbonitrile
("TBE-31"), which is useful for the treatment of various diseases and disorder in m...
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WO/2014/140655A1 |
Described is a method of synthesizing 6-(5-ethoxyhept-1-yl)bicyclo[3.3.0] octan-3-one by reacting 3-(5-ethoxyhept-1-yl) cyclopentene with dichloroketene. The resulting reaction products are reacted with acetic acid and zinc to produce 4-...
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WO/2014/138666A1 |
The presently disclosed and/or claimed inventive concept(s) relates generally to retro-aldol reaction products and methods of making and using same. More particularly, but without limitation, the methods disclosed herein for producing th...
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WO/2014/131764A1 |
A Process for preparing ketene in the presence of a fluidized bed material with a surface area of up to about 600 m2/g. The process is further defined as a process for preparing ketene from a sugar or glycolaldehyde feedstock.
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WO/2014/124878A1 |
The present invention relates to a process for the preparation of bisdihaloalkyl pyrazoles of formula (V) starting from diketones and acylhalides reacted with a Lewis acid, and a subsequent reaction with a substituted hydrazine.
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WO/2014/122263A1 |
The present invention concerns a process for the isomerisation of an exo double bond toward an endo double bond being performed in the presence of a catalyst system comprising palladium (Pd) or platinium (Pt) and molecular hydrogen or a ...
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WO/2014/117070A1 |
Compounds having formulas (I) to (VIII), salts thereof, or combinations thereof and pharmaceutical compositions comprising one or more these compounds are described herein for the treatment of HIV and neurodegenerative effects caused by ...
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WO/2014/110036A1 |
Compounds of formula (I): [Formula should be inserted here]; where [Formula should be inserted here], n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed co...
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WO/2014/109712A1 |
The invention relates to new ligands that are used in a palladium source catalyst system and in palladium catalyzed method for asymmetric α-(hetero)arylation and a-vinylation of ketones. The invention further relates to a process for pr...
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WO/2014/104480A1 |
The present invention relates to a monomer for a hard mask composition expressed by chemical formula 1, to a hard mask composition comprising said monomer, and to a method for forming a pattern using said hard mask composition.
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WO/2014/096106A1 |
The present invention relates to a process of manufacturing compound having stereogenic centres from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired config...
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WO/2014/099426A1 |
A cleavage process for making phenol and/or cyclohexanone, the process comprising: (A) providing a feed comprising cyclohexylbenzene hydroperoxide; (B) contacting the feed with a catalyst under cleavage reaction conditions effective to p...
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WO/2014/097171A1 |
The present invention relates to a process of a cis/trans isomerization of an unsaturated compound A being selected from the group consisting of unsaturated ketones, unsaturated ketals, unsaturated aldehydes, unsaturated acetals, unsatur...
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WO/2014/096065A1 |
The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimetylpentadecan-2-one in a multistep synthesis from 6,10-dimetylundec-5-en-2-one or 6,10-dimetylundeca-5,9-dien-2-one. The process is very advantageous in th...
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WO/2014/097173A1 |
The present invention relates to a process of manufacturing (6R,10R) -6,10,14-trimethylpentadecan-2-one in a multistep synthesis from 6,10- dimethylundeca-3,5,9-trien-2-one. The process is very advantageous in that it forms in an efficie...
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WO/2014/097170A1 |
The present invention relates to a process of the asymmetric hydrogenation of an unsaturated ketone or aldehyde by molecular hydrogen in the presence of at least one chiral iridium complex and in the presence of at least one additive and...
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WO/2014/097172A1 |
The present invention relates to a process of a cis/trans isomerization of an unsaturated compound A being selected from the group consisting of unsaturated ketones, unsaturated ketals, unsaturated aldehydes, unsaturated acetals, unsatur...
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WO/2014/096107A1 |
The present invention relates to a process of manufacturing compound having stereogenic centres from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired config...
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WO/2014/096151A2 |
The present invention discloses the compound 6-chloro-3-(phenyl-d5)-inden-1-one (I) and routes of synthesis to obtain (I). In a further aspect the present invention discloses the use of (I) for the synthesis of (S)-6-chloro-3-(phenyl-d5)...
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WO/2014/096098A1 |
The present invention relates to a process of manufacturing (6R,10R)- 6,10,14-trimetylpentadecan-2-one in a multistep synthesis from a mixture of (5E,9E)-, (5E,9Z)-, (5Z,9E)- and (5Z.9Z)- isomers of 6, 10, 14-trimetylpentadeca- 5,9,13-tr...
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