Heterocyclic Compounds

Matches 101 - 150 out of 615	< 1 2 3 4 5 6 7 8 9 10 11 12 13 >

Document	Document Title
WO/2002/012184A1	PROCESS FOR PREPARING ALPHA-AMINO ACIDS AND THEIR DERIVATIVES INCLUDING PHENYLALANINE AND HOMOPHENYLALANINE AND THEIR INTERMEDIATES The invention relates to (D)- or (L)-alpha-amino acids and their derivatives comprising phenylalanine or homophenylalanine having formula (I) or (II) and a process for the preparation thereof by stereoselective synthesis from aziridine h...
WO/2002/012186A1	OPTICALLY ACTIVE AZIRIDINE-2-CARBOXYLATE DERIVATIVES AND A PROCESS FOR PREPARING THEM This invention relates to compounds of formula (I) having an aziridine-2-carboxylic group and a menthol group, a process for preparing such compounds, a method for obtaining optically active aziridine-2-carboxylate derivatives by optical...
WO/2002/012181A1	NOVEL DIAMINES HAVING A CASR MODULATING ACTIVITY The invention concerns diamines of general formula (I), wherein: A represents a group A1 or A2 of general formula (II); B represents a group B1 or B2 of general formula (III); X represents a SO¿2?, CH¿2?, C=O or COO; Y------Z represent...
WO/2002/000590A1	SYNTHESIS OF FUNCTIONALIZED AND UNFUNCTIONALIZED OLEFINS VIA CROSS AND RING-CLOSING METATHESIS The invention is directed to the cross-metathesis and ring-closing metathesis reactions between geminal disubstituted olefins and terminal olefins, wherein the reaction employs a Ruthenium or Osmium metal carbene complex. Specifically, t...
WO/2001/060795A1	PROCESSES FOR PREPARING OPTICALLY ACTIVE AMINO ACID DERIVATIVES An optically active amino acid derivative is prepared either by subjecting an optically active 3-haloalanine derivative (1) to N-protection followed by cyclization or cyclization followed by N-protection to prepare an optically active az...
WO/2001/032617A1	PROCESS FOR THE PREPARATION OF 7-AZABICYCLO[4.1.0]-HEPT-3-ENE-3-CARBOXYLIC ACID ESTERS A process for preparing 7-azabicyclo[4.1.0]hept-3-ene-3-carboxylic acid esters (VII) inexpensively, industrially advantageously, efficiently and on a large scale. This process is characterized by comprising reacting an epoxide (I) with a...
WO/2001/021585A2	BIS(1-AZIRIDINO-1-HYDROXYIMINOMETHYL)-DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF AS ANTI-TUMORAL AGENTS Disclosed are novel 1-aziridino-1-hydroxyiminomethyl derivatives of general formula (I), wherein R represents any organic group which can covalently bond to two aziridinoxim groups, R¿1? and R¿2? independently represent a hydrogen atom...
WO/2001/012599A1	NEW ETHYLAZIRIDINE DERIVATIVES AND THEIR PREPARATION METHODS This invention is related to new ethylaziridine derivatives of formula (I) and their preparation. The compounds are useful synthetic intermediates for the synthesis of HIV protease inhibitors and oligopeptide mimetics.
WO/2001/000545A1	PRODUCTION OF OPTICALLY ACTIVE $g(a)-HYDROXYACETALS Process for the heterogeneous and enantioselective hydrogenation of prochiral organic $g(a)-keto compounds with platinum as the catalyst in the presence of a soluble or immobilised chiral aromatic nitrogen base with at least one basic ni...
WO/2000/056708A1	CATALYTIC ASYMMETRIC SYNTHESIS OF CHIRAL AZIRIDINES The present invention relates to the synthesis of chiral cis-aziridines (IIIa and IIIb) by reacting an imine (I) with a diazo compound (II) in the presence of a chiral vaulted biaryl-Lewis Acid complex as shown.
WO/2000/055153A1	AMIDE DERIVATIVES The invention concerns amide derivatives of Formula (Ia) wherein X is - NHCO- or -CONH-; m is 0-3; R?1¿ is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0-2; R?2¿ is a gr...
WO/2000/044720A1	SYNTHESIS OF ETHYLENEIMINE DIMER The invention provides a method to synthesizing ethyleneimine dimer. This method of synthesis provides several advantages over previous methods: (1) the starting compounds are all relatively inexpensive; (2) the yield of product is great...
WO/2000/043549A1	LIPOPHILIC QUENCHING OF VIRAL INACTIVATING AGENTS Methods and compositions for the inactivation and removal of contaminants of a biological composition are disclosed. The methods include the steps of: (a) contacting the biological composition with an inactivating agent including an azir...
WO/2000/040557A1	PROCESS FOR THE FORMATION OF INTERMEDIATES USEFUL FOR THE PREPARATION OF PHARMACEUTICALS The invention relates to a synthetic chemical process for forming an intermediate useful in manufacturing certain known nerve growth stimulatory and neuroprotective compounds and certain known multidrug resistance inhibitors.
WO/2000/013683A2	NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS A range of aziridin-1-yl nitrobenzamides (A-C) are provided for use as prodrugs in conjunction with nitroreductase (NR) enzymes. The amides may have 1 or 2 N-substituents which may be bulky and polar. For example, 5-(aziridin-1-yl) -N-[2...
WO/2000/014063A1	THERAPEUTIC COMPOUNDS AND METHODS The invention provides agents and compounds (see (I) and (II)) for use in the treatment or prophylaxis of disease conditions caused or exacerbated by mammalian papillomaviruses, such as human papillomaviruses, as well as methods for the ...
WO/2000/010985A1	ENANTIOSELECTIVE CHIRAL SULPHIDE CATALYSTS AND A METHOD FOR THE MANUFACTURE THEREOF The invention relates to a chiral sulphide catalyst, having the structure of formula (IIa) or (IIb) or (IIc) or (IId), wherein X represents a hydrogen atom, alkyl, alkoxy, aryl or alkylaryl group, or a dialkyl nitrogen; Y is a side chain...
WO/2000/009463A1	STEREOSELECTIVE RING OPENING REACTIONS The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile, selected from the group consisting of water, alcohols, carboxylic acids, and thiols, an...
WO/1999/054319A1	12,13-MODIFIED EPOTHILONE DERIVATIVES The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives and intermediates therefor.
WO/1999/054318A1	12,13-CYCLOPROPANE EPOTHILONE DERIVATIVES The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives and intermediates therefor.
WO/1999/047491A1	FLUOROVINYLOXYACETAMIDES, PROCESS FOR PREPARING SAME AND HERBICIDAL COMPOSITION COMPRISING SAME Herbicidal fluorovinyloxyacetamide compounds of formula (I) are useful for protecting crops from weeds, wherein: R?1¿ is a phenyl group optionally having one or more substituents selected from the group consisting of C¿1-6? alkyl, halo...
WO/1999/031047A1	CYCLOHEXENE CARBOXYLATES AS NEURAMINIDASE INHIBITORS Novel compounds of Formula (I) are described. R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and R?6¿ are described in this specification. Synthetic intermediates and pharmaceutical compositions comprising the inhibitors of the invention are also de...
WO/1999/029661A1	ADAMANTANE DERIVATIVES The invention provides adamantane derivatives, a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy. A compound for general formul...
WO/1999/017802A1	METHODS AND COMPOSITIONS FOR THE SELECTIVE MODIFICATION OF NUCLEIC ACIDS Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having formula (I), where each of R¿1?, R¿2?, R¿3?, R¿4?, R¿6?, R�...
WO1998051660A9	METHODS AND COMPOSITIONS FOR THE SELECTIVE MODIFICATION OF NUCLEIC ACIDS This invention provides means and methods of inactivating viruses and other organisms in cell-containing or biopolymer-containing compositions without significant alteration of proteins or other biopolymers by contacting such composition...
WO/1999/014185A1	COMPOUNDS CONTAINING SIX-MEMBERED RINGS, PROCESSES FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibit...
WO/1999/000120A1	NOVEL CYANOAZIRIDINES FOR TREATING CANCER This invention relates to novel cyanoaziridines for treatment of cancer.
WO/1998/051666A2	PROCESS FOR THE PREPARATION OF AN OXIRANE, AZIRIDINE OR CYCLOPROPANE A process for the preparation of an oxirane, aziridine or cyclopropane of formula (I) wherein X is oxygen, NR?4� or CHR?5??; R?1� is hydrogen, alkyl, aryl, heteroaromatic, heterocyclic or cycloalkyl; R?2� is hydrogen, alkyl, aryl, ...
WO/1998/047886A1	SUBSTITUTED BENZYL OXIMINO COMPOUNDS, The invention relates to benzyl oximino compounds of formula (I), wherein the substituents have the following meanings: X = N(COOCH�3?)-OCH�3?, C(COOCH�3?)= CH-OCH�3?, C(COOCH�3?)=N- OCH�3?, C(CONHCH�3?)=N-OCH�3? or C(COO...
WO/1998/042657A1	SYNTHESIS OF $g(a),$g(b)-SUBSTITUTED AMINO AMIDES, ESTERS AND ACIDS $g(a),$g(b)-Unsaturated amides and esters are converted to $g(a),$g(b)-substituted amino amides, esters, and acids. An $g(a),$g(b)-unsaturated amide or ester is first converted to an $g(a), $g(b) hydroxysulfonamide or hydroxycarbamate am...
WO/1998/019983A1	FUNCTIONALIZATION OF HYDROCARBYL-CONTAINING COMPOUNDS This invention is directed to processes for producing acyclic or cyclic alcohols or glycols, carbonyls, oxiranes or aziridines from hydrocarbyl group-containing compounds, particularly lower alkanes such as methane, ethane, propane or bu...
WO/1998/015529A1	PREPARATION OF CAPROLACTAM The invention concerns the aminomethylation of pentenoic acid derivatives, by reaction with carbon monoxide, hydrogen and ammonia, for preparing caprolactam. More precisely it consists in a method for preparing caprolactam, characterised...
WO/1998/011064A1	STEREOSPECIFIC PREPARATION OF CHIRAL 1-ARYL- AND 1-HETEROARYL-2-SUBSTITUTED ETHYL-2-AMINES This invention is directed to methods for stereospecifically preparing [(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)]-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to ...
WO/1998/007685A1	PREPARATION OF CYCLOHEXENE CARBOXYLATE DERIVATIVES The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates such as those having formulas (I)-(IV), such as those having formulas (I)-(IV), useful in the synthesis of neura...
WO/1998/005659A1	AZABICYCLIC CARBAMOYLOXY MUTILIN DERIVATIVES FOR ANTIBACTERIAL USE Compounds of formula (3), and pharmaceutically acceptable salts and derivatives thereof, in which R?1� is vinyl or ethyl; and R?2� is a group R?3�, R?4�CH�2?-, or R?5�R?6�C=CH-; wherein each of R?3� and R?4� is an azabi...
WO/1998/005636A1	METHOD FOR PURIFYING LACTAMS A method for purifying lactams by liquid-liquid extraction and/or processing with an ion exchange resin is disclosed. The method is useful for purifying lactams produced by the cyclising vapour-phase hydrolysis of an aliphatic aminonitri...
WO/1997/025309A1	CARBAMOYLOXY DERIVATIVES OF MUTILINE AND THEIR USE AS ANTIBACTERIALS Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is unsubstituted, or mono- or di-substituted, are useful...
WO/1997/024390A1	LINEAR POLYMERS OF N-(2-1'-AZIRIDINO)ETHYL)FORMAMIDE, PROCESS FOR THEIR PRODUCTION AND THEIR USE Linear polymers of N-(2-(1'-aziridino)ethyl)formamide obtainable by the polymerisation of N-(2-(1'-ariridino)ethyl)formamide in aqueous or alcoholic solution or in mixtures of water and alcohols at temperatures of up to a maximum of 75 �...
WO/1997/021674A1	NEW MARKER, PRODUCTION PROCESS AND USE THEREOF The invention relates to the trans isomer of 4-iodotamoxifenaziridine and particularly when it is marked by a radioactive isotope of iodine, more particularly iodine 125. The invention also relates to the preparation of said pure trans i...
WO/1997/016453A2	PANCRATISTATINS AND PROCESSES FOR THEIR PRODUCTION Disclosed are novel pancratistatins and methods for their total asymmetric synthesis. In particular embodiments, processes for the total asymmetric synthesis of (+)-pancratistatin, (-)-pancratistatin, (+)-7-deoxypancratistatin, (-)-7-deo...
WO/1997/007674A1	METHODS AND COMPOSITIONS FOR THE SELECTIVE MODIFICATION OF NUCLEIC ACIDS This invention provides means and methods of inactivating viruses and other organisms in cell-containing or biopolymer-containing compositions without significant alteration of proteins or other biopolymers by contacting such composition...
WO/1996/033018A1	CUP CATALYST AND PROCESS FOR PRODUCING AZIRIDINES A cup catalyst consisting of a glass substrate, the pores of which have a diameter of at least 10 nm and on which there is a catalytically active layer containing compounds of elements from the alkaline metal, alkali metal earth and/or l...
WO/1996/031473A1	NOVEL HETEROCYCLIC COMPOUNDS A compound of formula (I), in which Z is selected from (a), (b), (c), (d), (e), (f), (g), (h), (i), (j) and (k). The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substitu...
WO/1996/031474A1	NOVEL HETEROCYCLIC COMPOUNDS A compound of formula (I), in which Z is selected from (a), (b), (c), (d), (e), (f), (g), (h), (i), (j) and (k). The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substitu...
WO/1996/028420A2	PREPARATION OF N-ARYLMETHYL AZIRIDINE DERIVATIVES, 1,4,7,10-TETRAAZACYCLODODECANE DERIVATIVES OBTAINED THEREFROM AND N-ARYLMETHYL-ETHANOL-AMINE SULPHONATE ESTERS AS INTERMEDIATES Aziridines may be subjected to a cyclooligomerization reaction to produce polyazacycloalkane compounds useful for example in the preparation of chelating agents for use in diagnostic imaging contrast agents. N-benzyl-aziridine in particu...
WO/1996/026933A1	NOVEL SELECTIVE INHIBITORS OF VIRAL OR BACTERIAL NEURAMINIDASES Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibit...
WO/1996/026186A1	AZAFULLERENES, METHOD FOR PRODUCING THEM AND THEIR USE The invention pertains to a fullerene derivative of formula (I), wherein F is a fullerene radical of the formula C20+2m, with m = 2 to 100, and/or a fullerene adduct thereof, and n is a natural number from 1 to 10+m, with m = 2 to 100; t...
WO/1996/024644A1	PROCESS FOR THE PRODUCTION OF AN ARTICLE COATED WITH A CROSSLINKED PRESSURE SENSITIVE ADHESIVE This invention relates to a process in which a composition is coated onto a substrate and crosslinked so as to form a PSA by means of polymerizing free radically polymerizable monomers from covalently attached pendent unsaturation in the...
WO/1996/024061A1	METHODS AND APPARATUS FOR SYNTHESIZING LABELED COMBINATORIAL CHEMICAL LIBRARIES The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that spec...
WO/1996/022965A1	NOVEL AROMATIC AMIDES, METHOD FOR PREPARING AND COMPOSITIONS CONTAINING SAME, AND USE THEREOF AS PESTICIDES Compounds of formula (I), Q-(CH2)a-(X1)b-Q1-Q2-C(X2)-N(R1)(R2), wherein Q is an aryl radical, X1 is oxy, thio, sulphinyl or sulphonyl, X2 is oxygen or sulphur, Q1 is a cyclopropanediyl radical, Q2 is an arylene radical, and R1 and R2 are...

Matches 101 - 150 out of 615	< 1 2 3 4 5 6 7 8 9 10 11 12 13 >