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Matches 201 - 250 out of 615

Document Document Title
JP2015510509A
Methods and intermediates useful for preparing compounds of formula I and salts thereof. In the formula, R1aAnd R1bAre independently amine protecting groups or R1aIs an amine protecting group, R1bIs H and R1cIs -C (O) O (C1~ C6) Alkyl an...  
JP2015500905A
The present invention relates to modifications of polymeric materials containing reactive carbon-carbon unsaturateds and amines containing aziridine used for such modifications. Polymeric materials containing carbon-carbon bonds can be m...  
JP5555919B2  
JP5550880B2
The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy...  
JP5475863B2
The present invention relates to an improved method for preparing dipeptidyl peptidase-IV inhibitor which is able to reduce preparations costs by using low cost reagents in the reaction steps and is able to be used in mass production by ...  
JP5368803B2
There is provided 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide for various uses, as well as pharmaceutical compositions and devices comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide. There is also provided a method for ...  
JP5268912B2
Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-Beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11...  
JP2013107844A
To provide a method that synthesizes an optical activity aziridine compound through one step, using a compound that has not optical activity as a raw material compound.The manufacturing method of a compound of formula (3) comprises as fo...  
JP2013075272A
To provide a catalyst for producing an aziridine compound, which has specific composition and a specific ratio of the acid strength amount thereof to the base strength amount, and to provide a technique for producing the aziridine compou...  
JP5188706B2
There is provided a polydiacetylene supramolecule comprising diacetylene molecules, capable of immobilizing a receptor molecule having a thiol group. Since the polydiacetylene supramolecule has a receptor immobilized thereon having a thi...  
JP5122275B2
The invention provides novel inhibitors of IAP that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: X1 and X2 are independently O or S; L is a bond or -C(X3)-, -C(X3)NR12, -C(X...  
JP5086513B2
N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.  
JP2012529473A
The invention relates to nitrogen-containing inorganic carrier materials, more particularly to inorganic carrier materials containing organically bonded nitrogen, to their preparation and also to their use for stabilizing iodine-containi...  
JP2012192337A
To provide a catalyst that can effectively produce an aziridine while maintaining performance even under such reaction conditions that water vapor is contained in reaction gas in particular regarding the catalyst for producing the azirid...  
JP4954378B2
The invention provides a multistep synthesis for the preparation of 4,5-diamino shikimic acid derivatives of formula starting from furan. 4,5-Diamino shikimic acid derivatives are potent inhibitors of viral neuraminidase.  
JP4896350B2
The invention concerns diamines of general formula (I), wherein: A represents a group A1 or A2 of general formula (II); B represents a group B1 or B2 of general formula (III); X represents a SO2, CH2, C-O or COO; YZ represents a group of...  
JP4860865B2
Described are new 1-aziridino-1-hydroxyiminomethyl derivatives with the general formula (I), wherein R is able to is a single bond or a linker moiety capable of covalently bonding two aziridine oxime groups, R1 and R2 independently of on...  
JP2012006921A
To provide a new high-yield and practical chemical synthetic method of oseltamivir phosphate, with which the oseltamivir phosphate is obtained from an easily available raw material compound with high optical purity.In the new chemical sy...  
JP2011224551A
To enhance an aziridine production efficiency, by restraining catalyst activity from getting low caused by selection of a carrier and a firing temperature.This catalyst is a catalyst for producing the aziridine compound by a gas-phase in...  
JP4767399B2
There is provided a method of efficiently removing polymer stuck to the inside and/or on the surface of packings of a distillation tower, when nitrogen-containing polymerizable monomers (for example, ethyleneimine) are distilled. Said me...  
JP4760712B2
The present invention relates to novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs in hypoxic tumours, and to their use in cel...  
JP4759129B2
In order to carry out various vapor-phase reactions (e.g., the preparation of aziridine compounds by a vapor-phase intramolecular dehydration reaction) with industrial advantages, there is provided a process which can effectively prevent...  
JP2011512412A
This invention is directed to a 3-(amido or sulphamido)-4-(4-substituted-azinyl)benzamide or benzsulphonamide compound as defined herein. The 3-(amido or sulphamido)-(4-substituted-azinyl)benzamide or benzsulphonamide compound is useful ...  
JP4619545B2
The invention concerns amide derivatives of Formula (Ia) wherein X is -NHCO- or -CONH-; m is 0-3; R1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0-2; R2 is a group suc...  
JP4594386B2
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/...  
JP4575666B2
The present invention provides a process for producing an aziridine-1-carboxamide of the formula:from an aziridine of the formula:and an isocyanate of the formula R5-N=C=O, where R1, R2, R3, R4 and R5 are those defined herein. In additio...  
JP4564010B2
This invention provides a method for producing an optically active aziridine compound or amine compound, which uses as a catalyst a Ru(salen)(CO) complex represented by the following formula (I) or its enantiomer having a high stability,...  
JP2010209090A
To provide an immediate release pharmaceutical formulation that contains a pharmaceutically acceptable diluent or carrier and is useful for treatment of cardiovascular diseases. The immediate release pharmaceutical formulation contains a...  
JP2010530864A
Preparation of N-unsubstituted aziridine (II) or N-substituted aziridine (III) comprises reacting an olefin compound (I) with ammonia or a primary amine compound (IV), in the presence of iodine or bromine, where the concentration of (IV)...  
JP2010522140A
The present invention relates to novel compounds suitable for or already radiolabelled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging.  
JP4476483B2
The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives and intermediates therefor.  
JP4422895B2
Novel compounds of Formula (I) are described. R1, R2, R3, R4, R5 and R6 are described in this specification. Synthetic intermediates and pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods o...  
JP4402462B2
The present invention relates to a process for the preparation of perfluoroalkanesulfonic acid esters and to the further conversion thereof into salts, and to the use of the resultant compounds in electrolytes and in batteries, capacitor...  
JP4374658B2  
JP4353901B2
The present invention relates to a composition comprising at least one polyfunctional aziridine compound and 1,4-diazabicyclo[2.2.2]octane. The present invention furthermore relates to the use of this composition as a curing component fo...  
JP2009167210A
To provide a new synthetic method and a composition and to provide a new method for preparing an intermediate useful in the synthesis of neuraminidase inhibitor and to provide a composition useful as an intermediate that is itself useful...  
JP4237224B2
The invention provides a multi-step process for preparing 1,2-diamino compounds of formula wherein R1, R1', R2, R2', R3 and R4 have the meaning given in the specification and pharmaceutically acceptable addition salts thereof, from 1,2-e...  
JP4234917B2
Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibit...  
JP4213435B2  
JP4205559B2  
JP4204069B2
PCT No. PCT/EP97/04166 Sec. 371 Date Jan. 29, 1999 Sec. 102(e) Date Jan. 29, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/05659 PCT Pub. Date Feb. 12, 1998Compounds of formula (3), and pharmaceutically acceptable salts and derivatives ...  
JP2008545706A
One aspect of the present invention relates to an asymmetric catalytic nitroaldol (Henry) reaction with a ketone, which is an electrophilic component. In one embodiment, the invention relates to an asymmetric nitroaldol reaction with an ...  
JP2008542415A
The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a pr...  
JP2008273841A
To provide an intermediate useful for producing a benzylamine derivative, and a method for producing the intermediate.The method for producing an ethylenediamine derivative represented by formula (6) is characterized by reacting an aziri...  
JP2008273948A
To provide inhibition of viruses (especially influenza virus), especially, inhibition of glycolytic enzymes such as neuraminidase, and, especially, viral or bacterial neuraminidase inhibitors, to provide a method for synthesizing the inh...  
JP2008266336A
To improve energy balance and a yield upon production of an alkylene imine by allowing a sulfate monoester of an aminoalkanol to react with an aqueous base at a temperature of 110C or higher and under pressure, reducing the pressure of t...  
JP4177483B2
Sulphonamide derivatives of formula (I) and their stereoisomers and salts are new. R1 = Ar or Het; Ar = phenyl (optionally substituted by 1 or 2 alkyl, 3-6C cycloalkyl, OH, alkyl-COO-, alkyl-O-, alkyl-O-(1-4C alkylene)-O-, halo, CF3, CN,...  
JP4163254B2
PCT No. PCT/EP96/05874 Sec. 371 Date Dec. 4, 1998 Sec. 102(e) Date Dec. 4, 1998 PCT Filed Dec. 19, 1996 PCT Pub. No. WO97/25309 PCT Pub. Date Jul. 17, 1997Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and ...  
JP4124736B2
The present invention provides compounds of formula (I) wherein A1, A2, A3, A4, A5, A6, A7, A8, A9, A10, U, V, W, m, n and p are as indicated in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful f...  
JP4115514B2
The invention provides a nitroreductase, obtainable from a bacterium having the following characteristics as exemplified by examples isolated from Escherichia coli B and Bacillus amyloliquifaciens: 1. It is a flavoprotein having a molecu...  

Matches 201 - 250 out of 615