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WO/2019/151419A1 |
Provided are: a polycarbonyl compound, and a derivative of said polycarbonyl compound. The polycarbonyl compound includes a chemical structure represented by formula (1n). Also provided are: a furan compound including a chemical structur...
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WO/2019/152546A2 |
A salt compound of 4-(2-((4-bromophenyl)thio)acetamido)-1-phenethyl-1H-pyrazole
-3- carboxylic acid is disclosed. Also disclosed are methods for making the salt compound and formulations of the salt compound into dosage forms for clinica...
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WO/2019/148136A1 |
The present invention provides compounds, compositions thereof, and methods of using the same. Compounds of this invention, and pharmaceutically acceptable compositions thereof, are effective as inhibitors of GCN2 kinase.
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WO/2019/144765A1 |
Provided in the present application are an aromatic heterocyclic substituted olefin compound, a preparation method for same, a pharmaceutical composition of same, and applications thereof. The aromatic heterocyclic substituted olefin com...
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WO/2019/142107A1 |
The present invention relates to a novel and improved process for preparation of methyl [2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)phenyl]m
ethoxycarbamate (Pyraclostrobin)of formula (I) in free form or in agrochemically accepta...
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WO/2019/144041A1 |
Provided are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein A, Z, B, R1, R2, R3, G1, G2, and G3 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of ...
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WO/2019/141259A1 |
Provided are a heterocyclic compound, a preparation method and the use thereof in medicine, and particularly involved are a heterocyclic compound for preventing and/or treating hyperuricemia and gout, a preparation method and the use the...
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WO/2019/142191A1 |
Novel compounds capable of inhibiting methionine metabolic pathway are provided. These compounds are used in inhibiting cystathionin y-synthase (CGS) in general, and in plants, fungi and bacteria, in particular. These compounds of the in...
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WO/2019/142192A1 |
Novel compounds capable of inhibiting methionine metabolic pathway are provided. These compounds are used in inhibiting cystathionin γ-synthase (CGS) in general, and in plants, fungi and bacteria, in particular. These compounds of the i...
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WO/2019/136314A1 |
Provided are compounds having Formula (1), compositions thereof, and methods of modulating CFTR activity. Also provided are methods of treating a condition associated with decreased CFTR activity comprising administering to a subject an ...
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WO/2019/131922A1 |
The present invention provides a compound that has β2-adrenergic receptor antagonist activity and carbonic anhydrase-inhibitory activity, and that exhibits excellent ocular antihypertensive activity. Specifically provided is a compound ...
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WO/2019/128871A1 |
Disclosed are an N-alkyl-N-cyanoalkylbenzamide compound: general formula (I), and an intermediate with general formula (II) used for preparing the compound, wherein: R1 is selected from halogen or C1-C3alkyl; R2 is selected from halogen ...
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WO/2019/128918A1 |
Disclosed in the present invention are an aromatic vinyl or aromatic ethyl derivative, a preparation method therefor, an intermediate, a pharmaceutical composition, and an application. The aromatic vinyl or aromatic ethyl derivative in t...
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WO/2019/119516A1 |
Disclosed are a tetramethylspiroindene skeleton-based bisoxazoline ligand compound, an intermediate thereof, a preparation method therefor, and a use thereof. The bisoxazoline ligand compound is a compound having a structure as shown in ...
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WO/2019/122204A1 |
Disclosed are processes for the manufacture of pyrazole compounds of formula (I) and their application in the manufacture of pyrazole derivatives, in particular in processes for the manufacture of pharmaceutically or agrochemically activ...
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WO/2019/123375A1 |
This invention, in at least some embodiments, relates to an inventive molecule, compositions comprising same, and methods of use therof for treatment of a neurological disorder.
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WO/2019/121159A1 |
The present invention relates to the compounds of formula (I), and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein the variables are defined according to the description, formula...
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WO/2019/126613A1 |
Provides herein are novel compounds, compositions, and methods useful for inhibiting bacteria, such as Mycobacterium tuberculosis. These compositions and methods find many uses in medicine and research, e.g., treating subjects afflicted ...
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WO/2019/123368A1 |
The present invention relates to an improved and efficient process for the synthesis of 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropy
l]-2,4-dihydro-3H-1,2,4- triazole-3-thione, compound of formula (I) (Prothioconazole). T...
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WO/2019/126431A1 |
The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the tr...
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WO/2019/126424A1 |
The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the tr...
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WO/2019/124537A1 |
Provided is an agricultural and horticultural fungicide manifesting a high control effect against a wide range of plant pathogens. The compound represented by formula (1): (in the formula, each symbol is as described in the specification...
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WO/2019/119481A1 |
Provided is a kinase inhibitor, comprising a compound of formula (I), or a pharmaceutically acceptable salt, a solvate, an ester, an acid, a metabolite, or a prodrug thereof. Further provided are a pharmaceutical composition comprising t...
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WO/2019/120218A1 |
A pyrazole amide microbicide, having a structural formula of N-[2-[2-bromo-4-(trifluoromethyl)phenoxy]phenyl]-1-methyl-3-
difluoromethyl-1H-pyrazole-4-carboxamide. The microbicide has significant control effect against soybean rust, corn...
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WO/2019/124538A1 |
Provided is an agricultural and horticultural fungicide exhibiting a high control effect against a wide range of plant pathogens. A compound represented by formula (1) or a salt thereof (in the formula, each symbol is as defined in the d...
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WO/2019/126098A1 |
The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhi...
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WO/2019/123378A1 |
This invention, in at least some embodiments, relates to an inventive molecule, compositions comprising same, and methods of use therof for treatment of a neurological disorder.
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WO/2019/122194A1 |
Process for the manufacture of iminium compounds and their application in the manufacture of pyrazole derivatives The present invention concerns processes for the manufacture of iminium compounds and their application in the manufacture ...
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WO/2019/122164A1 |
The present invention concerns processes for the manufacture of pyrazole carboxylic derivatives and precursors thereof.
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WO/2019/115404A1 |
A compound of formula I, (I), wherein the substituents are as defined in claim (1), and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.
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WO/2019/118648A1 |
This disclosure concerns electrically conducting poly(pyrazoles). The concept of oligomerizing and polymerizing substituted aminopyrazole derivatives combined with a monomer activation procedure involving base-mediated conversion of the ...
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WO/2019/114526A1 |
The present invention relates to the field of pesticides. Disclosed are a pyrazole amide compound and an application thereof, and a fungicide. The pyrazole amide compound has a structure as represented by the following formula (I). The p...
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WO/2019/115781A1 |
The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit t...
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WO/2019/110795A1 |
This invention concerns a process for the manufacture of carboxylic acids or carboxylic acid derivatives and a process for the manufacture of agrochemically and pharmaceutically active compounds comprising the process for the manufacture...
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WO/2019/108800A1 |
The invention relates to compounds that promote hematopoietic regeneration. The invention further relates to methods of promoting hematopoietic regeneration using the novel compounds of the invention.
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WO/2019/108565A1 |
Pyranoyrazoles and pyrazolopyridines of formula I or formula II are disclosed: (I), (II) These compounds inhibit Coagulation Factor Xlla in the presence of thrombin and other coagulation factors. They are useful to treat autoimmune disea...
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WO/2019/104067A1 |
Provided are methods of increasing a response to a chemotherapeutic agent or an immunotherapeutic agent in a patient in need thereof, and methods of treating cancer in a patient in need thereof, comprising administering to the patient a ...
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WO/2019/097515A1 |
The present invention relates to novel ACSS2 inhibitors having activity as anti-cancer therapy, treatment of alcoholism, and viral infection (e.g., CMV), composition and methods of preparation thereof, and uses thereof for treating viral...
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WO/2019/099314A1 |
Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder...
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WO/2019/092171A1 |
The present invention relates to sulfonylureas and sulfonylthioureas comprising a5-membered heteroaryl group substituted with a monovalent heteroaryl-containing group. The present invention further relates to salts, solvates and prodrugs...
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WO/2019/092172A1 |
The present invention relates to sulfonylureas and sulfonylthioureas comprising a 5-membered nitrogen-containing heteroaryl ring attached to the sulfonyl group, wherein the heteroaryl ring is substituted with at least one monovalent grou...
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WO/2019/091277A1 |
Provided are a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, ether, ester, prodrug and solvate thereof. The compound can be used for preventing and/or treating cancers.
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WO/2019/092170A1 |
The present invention relates to sulfonylureas and sulfonylthioureas comprising as-membered nitrogen-containing heteroaryl ring attached to the sulfonyl group, wherein the heteroaryl ring is substituted with at least one group containing...
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WO/2019/090818A1 |
The invention falls within the technical field of pesticides, and in particular relates to a 4-benzoylpyrazole compound and a preparation method therefor and the use thereof. The chemical structure of the 4-benzoylpyrazole compound is as...
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WO/2019/090082A1 |
Provided herein are compounds, compositions, and methods useful for the modulation of elF2B and the integrated stress response (ISR) signaling pathway and for treating related diseases, disorders and conditions.
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WO/2019/090069A1 |
Provided herein are compounds, compositions, and methods useful for the modulation of elF2B, for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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WO/2019/086494A1 |
Provided are compounds having the general formula I: wherein R1, R B1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds. The compound...
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WO/2019/090074A1 |
Provided herein are compounds of formula (I) and (II), compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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WO/2019/087548A1 |
Provided is a fluorine-containing ether compound which is capable of forming a lubricating layer that has excellent wear resistance even if the thickness thereof is thin, and which is suitable as a material for a lubricant for magnetic r...
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WO/2019/085876A1 |
The present invention discloses a continuous-flow clean production process for pyrazolone series products, comprising reacting an aromatic amine with an aqueous sulfuric acid solution for 0.5-2 h to obtain an aromatic amine sulfate solut...
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