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WO/2000/027795A1 |
Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having general structure (A).
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WO/2000/027814A1 |
A covalent conjugate of a 4'-hydroxyazobenzene-2-carboxylic acid derivative (HABA) and an avidin-type molecule, of formula (I), wherein A is (CH¿2?)¿n? or -CH=CH-, wherein n is an integer from 0-10; B is (CH¿2?)¿n? wherein n is an in...
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WO/2000/026201A1 |
The invention relates to benzoyl pyridazine derivatives of formula (I), wherein R?1¿, R?2¿, R?3¿ and Q have the meaning defined in claim 1. Said derivatives have a phosphodiesterase IV inhibiting effect and can be used in the tr...
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WO/2000/023429A2 |
This invention provides processes for preparing cryptophycin compounds of formula (II).
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WO/2000/023425A1 |
The present invention relates to compounds of general formula (Ia). The compounds are useful in the treatment and/or preventionof conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PP...
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WO/2000/021942A1 |
The invention relates to azadioxacycloalkenes of formula (I) in which the substituents R?1¿ to R?5¿ and X, the index n and the binding link W have the following meanings: R?1¿ represents C¿1?-C¿4?-alkyl, halogen, cyano, ha...
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WO/2000/018391A1 |
Drugs for improving vesical excretory strength which contain a non-carbamate amine compound having an acetylcholinesterase inhibitory effect.
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WO/2000/014079A1 |
The invention relates to new aza-cyclodepsipeptides of formula (I) in which X?1¿, X?2¿, X?3¿ and X?4¿ independently of each other are N or C-H and at least one of these variables X represents nitrogen. The invention also relates to a...
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WO/2000/012084A1 |
The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treat...
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WO/2000/008004A1 |
A non-aqueous, particle-forming, fused pyrrolocarbazole-containing composition is disclosed. Upon contact with an aqueous medium, the particle-forming composition spontaneously disperses into suspended particles, thereby forming a stable...
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WO/1999/067281A1 |
The invention relates to new substituted cyclooctadepsipeptides of formula (I) wherein R?1¿, R?2¿, m and n are as defined in the description, a method for their preparation and their use for fighting endoparasites, as well as drugs con...
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WO/1999/063825A1 |
Compositions containing the compounds of Formula (I) and methods of their use as arthopodicides in non-agronomic environments and in animal health environments are disclosed.
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WO/1999/064406A1 |
The present invention relates to processes for the preparation of macrocyclic molecules containing anti-succinate residues which inhibit metalloproteinases such as aggrecanase, and the production of tumor necrosis factor (TNF). The anti-...
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WO1999051222A9 |
The present invention describes an isolated macrocycle having formula (I), where d is an integer from 0 to about 100; A, B, and each D are the same or different and are selected from the group consisting of formula (II) and formula (III)...
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WO1999051565A9 |
Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to ...
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WO/1999/055665A1 |
The invention relates to novel azines, to a method for producing said azines and to their use as fungicides.
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WO/1999/047520A1 |
A process for the production of a compound of formula (I), wherein R¿1? is hydrogen or C¿1?-C¿4?-alkyl; R¿2? is hydrogen, C¿1?-C¿6?-alkyl, C¿2?-C¿6?-alkenyl, C¿2?-C¿6?-alkinyl, C¿3?-C¿6?-cycloalkyl or a radical -CH¿2?B; A is...
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WO/1999/047525A1 |
Compounds of formula (I), in which the subsituents are as defined in claim 1, are suitable for use as herbicides, in particular in combination with herbicide-antagonistically effective compounds.
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WO/1999/047506A1 |
The invention relates to novel cyclooctadepsipeptides of formula (I), wherein R?1¿ represents cyano, C-C-bonded heterocyclyl or optionally, substituted alkenyl, alkinyl or aryl and R?2¿ represents hydrogen or the same radical as R?1¿....
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WO/1999/041245A1 |
Insecticidal dihydro-oxadiazine compounds having formula (I): wherein X is O, N or S; R is a substituted or unsubstituted phenyl or C¿4?-C¿5? heterocyclic group; R?2¿, R?3¿, R?4¿, and R?5¿ are one of the following: a) R?2¿, R?3¿,...
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WO/1999/032463A1 |
This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
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WO/1999/025701A1 |
The invention relates to carboxylic acid derivatives of formula (I) wherein A represents NR?8¿R?9¿, azido, OR?10¿, SR?10¿ or C¿1?-C¿4? alkyl, R?1¿ represents tetrazole or a group (1), wherein R has the following meaning: a) a radi...
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WO/1999/024412A1 |
A novel crystal of the depsipeptide derivative represented by chemical formula (IV). The crystal is excellent in the filtrability during crystallization and improved in the efficiency and yield of production.
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WO/1999/019312A1 |
The invention relates to compounds of formula (I) in which Q represents a single bond of oxygen or sulfur, R represents alkyl or optionally substituted cycloalkyl with 3 to 5 carbon atoms, Z represents each optionally substituted cycloal...
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WO/1999/019311A1 |
The invention relates to novel azines of formula (I), wherein G stands for a single bond or group (a) wherein R?1¿means respectively optionally substituted alkyl, alkenyl, alkinyl or cycloalkyl, R represents alkyl or optionally substitu...
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WO/1999/015530A1 |
A compound having formula (I) or a pharmaceutically acceptable salt or prodrug thereof, is an immunomodulatory agent and is useful in the treatment of restenosis and immune and autoimmune diseases. Also disclosed are cancer-, fungal grow...
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WO/1999/009026A1 |
The invention relates to new methoximinomethyloxadiazines, two methods for their production, and their use as pesticides. The invention also relates to new intermediary products and a method for their production.
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WO/1999/005131A1 |
Compounds of formula (I) are useful as nitric oxide synthase inhibitors.
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WO/1999/003468A1 |
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compounds of formulae (I), (II), (III) and (IV) have structures wherein X, X¿...
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WO/1999/002514A2 |
The present invention relates to compounds of formula (V).
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WO/1998/055469A1 |
The invention relates to novel desoxycyclodepsipeptides of formula (I) in which C=X?1�, C=X?2�, C=X?3� and C=X?4� independently of each other respectively represent one of the CO, CS or CH�2? groups, with at least one of these ...
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WO/1998/054211A2 |
This invention relates to the cyclodepsipeptide represented by formula (1), wherein R?1a�, R?1b� and R?1c� are a hydrogen atom or a methyl group, R?2� and R?4� lower alkyl groups, and R?3� a lower alkyl group or an aralkyl gr...
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WO/1998/051665A2 |
This invention relates to macrocyclic molecules of formula (I) which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). The present invention also relates to pharmaceutical compositions ...
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WO/1998/046581A1 |
A composition for providing a synergistic treatment for cancer comprising a compound selected from the group consisting of Compound I, Compound II, Compound III, Compound IV, Compound V or a related cryptophycin compound and one or more ...
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WO/1998/045397A1 |
Novel bleaches, a method for bleaching substrates using these materials and bleaching compositions containing same are reported. The bleaches are N-acyl oxaziridines. Substrates such as fabrics may be bleached in an aqueous solution cont...
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WO/1998/045289A1 |
The invention concerns novel methoximinomethyldioxazines of formula (I), a plurality of processes for their preparation, and their use as fungicides, as well as novel intermediate products and a process for their preparation.
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WO/1998/043965A1 |
The invention relates to cyclic thiodepsipeptides, especially 18 to 24-link cyclothiodepsipeptides, cyclic thiodepsipeptides and their salts. These cyclic thiodepsipeptides are of general formula (I), wherein R?1�, R?4�, R?7� and R...
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WO/1998/040365A1 |
The invention relates to novel alkoximinomethyldioxazine derivatives of formula (I), a method for the production and the use thereof as fungicides, in addition to novel intermediate products and several methods for the production thereof.
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WO/1998/038178A1 |
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as antineoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering the...
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WO/1998/031682A1 |
The invention concerns 4-(3-heterocyclyl-1-benzoyl)pyrazoles of formula (I) in which the variables have the following meanings: R?1�, R?3�: hydrogen, nitro, halogen, cyano, alkyl, alkyl halide, alkoxy, alkoxy halide, alkylthio, alkyl...
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WO/1998/031681A1 |
The invention concerns benzoyl derivatives of formula (I) in which the variables have the following meanings: R?1�, R?2�: hydrogen, nitro, halogen, cyano, alkyl, alkyl halide, alkoxy, alkoxy halide, alkylthio, alkylthio halide, alkyl...
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WO/1998/030551A1 |
Macrocyclic compounds of formula (I) are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting comp...
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WO/1998/024877A2 |
Novel bleaches, a method for bleaching substrates using these materials and detergent compositions containing same are reported. The bleaches are thiadiazole dioxide derived mono- and di-oxaziridines. Substrates such as fabrics may be bl...
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WO/1998/017653A1 |
The invention relates to novel oxime derivatives of formula (I) , in which A stands for alkadiyl, Ar for optionally substituted aryls or heteroaryls respectively, G for a single bond, optionally an alkandiyl interrupted by heteroatoms (i...
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WO/1998/017617A1 |
The use of a fluorocompound comprising a perfluoropolyoxyalkyl/alkylene chain with an average molecular weight of not less than 800 and an atomic group of a cyclic/noncyclic polyether as a low-scattering lubricant/surface modifier (such ...
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WO/1998/016503A2 |
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-$g(a) converting enzyme (TACE, tumor necrosis fa...
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WO/1998/015523A1 |
An industrially excellent alternative process for producing cyclodepsipeptide derivatives, as represented in formula (1), having an excellent vermicidal activity as an animal and human anthelmintic, wherein R�1? represents hydrogen or ...
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WO/1998/014433A1 |
Compounds of the formula (I) wherein R?1� is a group of formula G?1�, G?2�, G?3�, G?4�, G?5�, G?6� or G?7�; Y is an optionally substituted (C�1?-C�4?) heteroalkyl bridge that, together with the atoms to which it is at...
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WO/1998/009955A1 |
This invention provides intermediates and processes useful for the preparation of crytophycin compounds.
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WO/1998/009988A1 |
This invention provides a process for preparing diastereomerically pure cryptophycin compounds.
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