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JP3364205B2 |
To provide a new pyridazinone compound useful as a bactericide. The new pyridazinone compound expressed by formula (1) (A is -CHR-O-Z-, -CHR-S-Z-, -O-CHR-Z- or -CR=N-Z-; D is CR; Q is a heterocyclic ring-containing aromatic residue; and ...
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JP3354150B2 |
Decomposition-sensitive complex ligands can be stabilised by derivatisation with the aid of bulky secondary or tertiary carboxylic or sulphonic acids. These stabilised derivatives can be added to alignment layers and liquid-crystal mixtu...
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JP2002536354A |
The invention provides fungicidal compounds of formula (I) and salts thereof wherein: R1 is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted, or hydrogen; R2 and R3, which may be the same or differen...
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JP2002534522A |
Compounds of formula IwhereinW is optionally substituted alkylene;Y is N or CRa;Ra is hydrogen, halogen or alkyl;R1n represents hydrogen or 1 to 4 substituents;R2 is hydrogen, nitro, cyano, halogen, alkyl, haloalkyl, alkoxy, alkylthio or...
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JP2002275194A |
To provide FO-6979-M0 substance, FO-6979-M1 substance, FO-6979-M2 substance, FO-6979-M3 substance and FO-6979-M4 substance having an inhibitory activity for acyl-coenzyme A(acyl-CoA) cholesterol acyltransferase and a method for producing...
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JP3328343B2 |
PURPOSE: To obtain a new compound, excellent in curability, drying properties, flexibility and compatibility and useful as a curing agent, a coating, etc. CONSTITUTION: This compound of formula I {R1 and R2 are 2-12C alkylene; at least o...
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JP2002527507A |
The present invention relates to compounds of general formula (Ia). The compounds are useful in the treatment and/or preventionof conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PP...
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JP2002527509A |
This invention provides processes for preparing cryptophycin compounds of formula (II).
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JP2002527427A |
The present invention relates to azadioxacycloalkenes of the formula Iin which the substituents R1 to R5 and X, the index n and the bridge member W have the following meanings:R1 is C1-C4-alkyl, halogen, C1-C4-haloalkyl, C3-C6-cycloalkyl...
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JP2002524453A |
The invention relates to new aza-cyclodepsipeptides of formula (I) in which X<1>, X<2>, X<3> and X<4> independently of each other are N or C-H and at least one of these variables X represents nitrogen. The invention also relates to a met...
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JP2002523455A |
The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treat...
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JP3307687B2 |
PURPOSE: To provide a new compound useful as a highly selective ion sensor (ion electrode) in the field of industrial process, food, basic medical research, etc. CONSTITUTION: The compound of formula I (R1 to R6 are H or hydrocarbon grou...
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JP3299752B2 |
The present invention relates to the use of cyclic depsipeptides having 18 ring atoms of the general formula (I) (I) in which R1 to R6 have the meaning given in the description, and to their optical isomers and racemates, in medicine and...
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JP2002518520A |
The invention relates to new substituted cyclooctadepsipeptides of formula (I) wherein R<1>, R<2>, m and n are as defined in the description, a method for their preparation and their use for fighting endoparasites, as well as drugs conta...
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JP2002173488A |
To provide an organic electroluminescent element having high luminous efficiency and long service life and capable of emitting blue-color light and solving problems that conventional hole transport material used for organic EL elements d...
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JP2002517416A |
[Chemical 1]
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JP2002517488A |
The present invention is directed to a process for the preparation of a compound of formula (X-a):or a pharmaceutically acceptable salt form thereof, wherein:R1 is selected from the group consisting of:C1-5 alkyl substituted with 0-5 R1a...
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JP2002515043A |
Pharmacophore models of VLA-4 inhibitors, methods of identifying novel inhibitors and novel inhibitors identified by these methods.
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JP3282047B2 |
PURPOSE: To inexpensively purify a crown compound simply and efficiently. CONSTITUTION: A crown compound is made into a complex, dissolved in an organic solvent, purified, mixed with water and recovered to purify the crown compound. The ...
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JP2002512998A |
The invention relates to novel azines, to a process for their preparation and to their use as fungicides.
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JP2002510669A |
Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to ...
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JP3268461B2 |
There is proposed a novel process for the preparation of 1,3-disubstituted 2-nitroguanidines of the formula I in which R1 is hydrogen or C1-C4-alkyl, R2 is hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl or a radical -CH2B; A is an aromati...
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JP3263947B2 |
A compound of the formula : wherein A is benzyl group which has suitable substituent (s), A, B and D are each lower alkyl, C is hydrogen or lower alkyl, or a salt thereof. The compound or its salt of the present invention has excellent p...
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JP2002506866A |
A process for the production of a compound of formula (I)whereinR1 is hydrogen or C1-C4-alkyl;R2 is hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl, C3-C6-cycloalkyl or a radical -CH2B;A is selected from the group consisiting of 2-ch...
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JP2002506857A |
The invention relates to novel cyclooctadepsipeptides of formula (I), wherein R<1> represents cyano, C-C-bonded heterocyclyl or optionally, substituted alkenyl, alkinyl or aryl and R<2> represents hydrogen or the same radical as R<1>. Th...
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JP3262277B2 |
PCT No. PCT/EP97/00151 Sec. 371 Date Jul. 16, 1998 Sec. 102(e) Date Jul. 16, 1998 PCT Filed Jan. 15, 1997 PCT Pub. No. WO97/27189 PCT Pub. Date Jul. 31, 1997Compounds of the formula (I) in which A represents optionally substituted alkane...
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JP3257784B2 |
To provide a compound having an excellent arthropod-killing activity, and to provide an arthropod-killing agent containing the compound as an active ingredient. A compound of formula (I) [Q is a group of formula (II) (R1 and R2 are each ...
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JP2002502398A |
The invention relates to novel deoxycyclodepsipeptides which are prepared from cyclodepsipeptides having 24 ring members which are constructed from alternating alpha-aminocarboxylic acids and alpha-hydroxycarboxylic acids, by complete or...
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JP2001354694A |
To provide a new compound useful as a medicine, especially as a histon-deacetylating enzyme(HDAC) inhibitor.This dithiol derivative or its pharmaceutically permissible salts has the HDAC-inhibiting activity and also a cytotoxcic activity...
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JP3242140B2 |
PURPOSE: To obtain a bactericidal compsn. having an improved effect. CONSTITUTION: A new bactericidal compsn. comprising one or more compound(s) selected from specified 6-aryl-2-(2-'-alkynyl)pyridazinones and/or 6-aryl-2-(2'- alkynyl)-4,...
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JP2001524952A |
The present invention relates to cyclic thiodepsipeptides, in particular 18 to 24-membered cyclothiodepsipeptides, their endoparasitical compositions, and methods of making and using the same.
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JP2001524949A |
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...
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JP2001523671A |
The present invention relates to carboxylic acid derivatives of the formula Ithe substituents having the meanings explained in the description, preparation and use as endothelin receptor antagonists.
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JP2001519420A |
The present invention is directed to compounds of having the formula (I)in whichG represents a single bond or a grouping andZ represents alkyl or halogenoalkyl or cycloalkyl or cycloalkylalkyl or heterocyclyl or heterocyclylalkyl or aryl...
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JP2001519421A |
The invention relates to new thioimides, a process for their preparation and their use as fungicides.
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JP2001518887A |
The invention relates to novel methoximinomethyldioxazines,to a plurality of processes for their preparation and to their use as fungicides, and also to novel intermediates and to a process for their preparation.
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JP2001518446A |
1,2,4-oxa-diazolino and 1,2,4-oxa-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
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JP2001518082A |
The invention relates to alkoximinomethyldioxazine compounds and intermediates thereof, and to process for the preparation of the alkoximinomethyldioxazine compounds and intermediates thereof. The alkoximinomethyldioxazine compounds have...
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JP2001515076A |
A compound of the formula (I)whereinZ represents a moiety selected from the group consisting of cycloalkyl having 3 to 7 carbon atoms in the cycloalkyl moiety or cycloalkylalkyl having 3 to 7 carbon atoms in the cycloalkyl moiety and 1 t...
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JP3210676B2 |
Compounds of formula (Ia) wherein Z is (a), wherein x is an integer from 0 to 4, n is an integer from 0 to 5 and R is defined below; or (b), wherein n is an integer from 0 to 5 and R is defined below; R is selected from the group consist...
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JP3207870B2 |
PURPOSE: To provide a novel compound useful as an anthelminthic. CONSTITUTION: A cyclic depsipeptide PF1022B of the formula. The substance is obtained by a PF-1022B substance-producing microorganism in an aconidial imperfect fungus is ae...
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JP2001513775A |
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as antineoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering the...
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JP2001510154A |
Compounds having kappa opioid agonist activity, compositions containing them and 5 method of using them as analgesics and pruritic agents are provided. The compounds of formulae I, II, III and IV have the structure: wherein X, X4, X5, X7...
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JP2001207073A |
To obtain an azomechine pigment precursor which exhibits a good developed color with less energy and becomes extremely good in storage stability of an image obtained, and to obtain a monochromatic or polychromatic image-forming material ...
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JP2001509151A |
Macrocyclic compounds of formula (I) are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting comp...
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JP2001172268A |
To provide a new cyclic polyether compound useful as a discotic liquid crystal material, and to provide an electrolyte which has anisotropic ion conductivity.This cyclic polyether compound represented by general formula (II) (X is CO or ...
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JP2001139597A |
To provide a new compound having antifungal activity. This compound is represented by the formula (I) or its salt.
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JP3166782B2 |
PURPOSE: To provide a new compd. for fungicide, especially useful for agricultural fungicide. CONSTITUTION: The compd. represented by formula I (the ring formed with D-NR1-A is dihydropyridazin-3-one, pyridazin-3-one, etc.; R1 is a lower...
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JP3159859B2 |
PURPOSE: To obtain a new compound useful as an agricultural and horticultural insecticide and its intermediate. CONSTITUTION: This nitro compound is expressed by formula I (A is 6-chloro3- pyridyl or 2-chloro-5-thiazolyl; R1 is H or meth...
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JP2001504809A |
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF- alpha converting enzyme (TACE, tumor necrosis f...
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