| Document |
Document Title |
|
WO/1994/018164A1 |
Taxol (I) is a complex diterpene which is currently considered the most exciting lead in cancer chemotherapy. Taxol possesses high cytotoxicity and strong antitumor activity against different cancers which have not been effectively treat...
|
|
WO/1994/018186A1 |
An efficient protocol for the synthesis of taxol, taxol analogs and their intermediates is described. The process includes the attachement of the taxol A-ring side chain to baccatin III and for the synthesis of taxol and taxol analogs wi...
|
|
WO/1994/017052A1 |
Taxane derivatives having alternative C2 substituent which is -OCOR31 wherein R31 is substituted phenyl and the substituent is selected from the group consisting of alkanoxy, protected hydroxy, halogen, alkyl, aryl, alkenyl, acyl, acylox...
|
|
WO/1994/017051A1 |
Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C2 substituent other than benzoate and/or a C4 substituent other than acetate in which the C2 benzoate substituent and/or the C4 ...
|
|
WO/1994/017050A1 |
Taxane derivatives having alternative C7 substituents wherein the substituents are independently selected from the group consisting of hydrogen and acyloxy. The derivatives are valuable antileukemia and antitumor agents.
|
|
WO/1994/015929A1 |
A process for abstracting a C10 hydroxy, acyloxy or sulfonyloxy substituent from a taxane in which the C10 hydroxy, acyloxy or sulfonyloxy substituted taxane is reacted with samarium diiodide.
|
|
WO/1994/015599A1 |
Taxane derivatives substituted on the C10 position with novel substituents are disclosed. The novel compounds have utility as antileukemia and antitumor agents.
|
|
WO/1994/014787A1 |
Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoli...
|
|
WO/1994/013654A1 |
Novel taxoids of general formula (I), the preparation thereof and pharmaceutical compositions containing same. In general formula (I), Ar is an aryl radical; R is a hydrogen atom or an acetyl, alkoxyacetyl or alkyl radical; R1 is a benzo...
|
|
WO/1994/013655A1 |
This invention provides 7-deoxy-taxol analogs of formula (I). The compounds of formula (I) (including formulae II and III) are useful for the same cancers for which taxol has been shown active, including human ovarian cancer, breast canc...
|
|
WO/1994/013827A1 |
A process for the separation of taxanes, particularly taxol, cephalomanine, baccatin III and deacetylbaccatin III, from ornamental yew tissue is described. The process involves a specific solvent mixture in water and 50 to 95 percent by ...
|
|
WO/1994/012486A1 |
The present invention is a method that uses an absorption column for the cleavage and recovery of taxanes, which are not normally detected as free taxanes. The method processes a first solution that contains standard detectable taxanes a...
|
|
WO/1994/012268A1 |
A method of processing a feed liquid (122) containing taxane solutes as a solute constituent to remove at least one solute constituent utilizes a semipermeable membrane (115) to separate first adn second regions (116, 118). The feed liqu...
|
|
WO/1994/012030A1 |
A composition of taxol and polyethoxylated castor oil is pH balanced to have a pH less than 8.1 to improve stability. This composition can include an acid, preferably citric acid, to adjust the pH value. The invention includes a method o...
|
|
WO/1994/012485A1 |
Novel taxoids of general formula (I), the preparation thereof and pharmaceutical compositions containing them. In general formula (I), Ar is an aryl radical; R is a hydrogen atom or an acetyl radical; and R1, is optionally substituted al...
|
|
WO/1994/012484A1 |
Novel method for the preparation of taxane derivatives having the general formula (I) and pharmaceutical compositions which contain the novel derivatives thus obtained. In the general formula (I), R is hydrogen or acetyl, R1 is benzoyl o...
|
|
WO/1994/012031A1 |
A composition of taxol and polyethoxylated castor oil is pH balanced to have a pH less than 8.1 to improve stability. This composition can include an acid, preferably citric acid, to adjust the pH value. The invention includes a method o...
|
|
WO/1994/011366A1 |
A process for the conversion of glycoside substituted taxanes to taxol and related compounds that can serve as precursors to taxol. The process includes the oxidation of glycoside substituted taxanes to convert the glycoside to the hydro...
|
|
WO/1994/011547A1 |
Process for the electrochemical preparation of taxane derivatives of general formula (I), based on a taxane derivative of general formula (III). The invention also concerns pharmaceutical compositions with outstanding antitumour and anti...
|
|
WO/1994/010996A1 |
Taxane derivatives having a 3' butenyl substituted C13 side chain.
|
|
WO/1994/010997A1 |
Taxane derivatives having an alkyl substituted C13 side-chain.
|
|
WO/1994/011362A1 |
Taxane derivatives of formula (3) wherein R1 is phenyl or p-nitrophenyl, R3 is furyl or thienyl, T1 is hydrogen, hydroxyl protecting group, or -COT2, T2 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or monocyclic aryl, Ac is acetyl, an...
|
|
WO/1994/010995A1 |
Antitumour combinations consisting of taxol or Taxot�re or analogues thereof combined with at least one therapeutically useful substance for treating neoplastic diseases.
|
|
WO/1994/010169A1 |
A method for preparing taxane derivatives of general formula (I) by esterifying protected baccatine III or protected 10-deacetyl baccatin III with an acid of general formula (II). In general formulae (I) and (II), Ar is an aryl radical; ...
|
|
WO/1994/010137A1 |
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compou...
|
|
WO/1994/008984A1 |
Novel taxane derivatives of general formula (I), their preparation by electrochemical reduction of a taxane derivative of general formula (III) and pharmaceutical compositions containing a product of general formula (I) in which R3 is a ...
|
|
WO/1994/007882A1 |
Method of obtaining 10-deacetylbaccatine III from different parts of the yew tree (Taxus sp.) by extraction and selective crystallization from a methanol extract of the plant mass.
|
|
WO/1994/007877A1 |
Method of preparing taxane derivatives of general formula (I) by esterification of protected baccatine III or 10-deacetylbaccatine III by means of an acid of general formula (VII), elimination of protection groupings of the ester obtaine...
|
|
WO/1994/007847A1 |
Method of stereoselective preparation of a derivative of beta-phenylisoserine of formula (I) by the action of an N-carbonylbenzylimine of formula (II) on an optically active amide of a protected hydroxyacetic acid of formula (III), follo...
|
|
WO/1994/007876A1 |
Method of preparing esters of baccatine III or 10-deacetylbaccatine III of formula (I) by esterification of protected baccatine III or 10-deacetylbaccatine III of formula (II) by means of an activated acid of formula (III). The esters of...
|
|
WO/1994/007878A1 |
Method of preparing taxane derivatives of general formula (I) by esterification of protected baccatine III or 10-deacetylbaccatine III by means of an acid of general formula (VII), deprotection of the side chain and elimination of the hy...
|
|
WO/1994/007881A1 |
Method of obtaining 10-deacetylbaccatine III from different parts of the yew tree (Taxus sp.) by extraction using a suitable organic solvent of the aqueous solution obtained after treatment of the appropriate part of the yew with water o...
|
|
WO/1994/007880A1 |
Novel derivatives of taxol analogues of general formula (I) preparation thereof and compositions containing them. In general formula (I): Ar stands for an aryl radical, R is a phenyl radical or a radical of general formula R6-O- (R6 = al...
|
|
WO/1994/007879A1 |
Method of preparing taxane derivatives of formula (I) by esterification of protected baccatine III or 10-deacetylbaccatine III by means of an acid of formula (VII), elimination of protection groupings and acylation of the amine function ...
|
|
WO/1994/006417A1 |
Patients with elevated blood levels of low-density lipoprotein (LDL) and total cholesterol are treated by administering beta-hydroxy-beta-methylbutyric acid (HMB) to reduce the patient's blood level of LDL and total cholesterol. HMB can ...
|
|
WO/1994/006422A1 |
The present invention is a method of treatment for a patient with cancer. In particular, it is a method of treating patients having lymphomas or breast cancer using the microtubule agent, Taxol. The present method of administration serve...
|
|
WO/1994/005282A1 |
Alkaline sensitive protaxol is water soluble and is hydrolyzed at physiological (alkaline) pH to render the native taxol structure and the native taxol activity. Protaxol compositions include 2\'-and/or 7-O-ester derivatives of taxol and...
|
|
WO/1994/005639A1 |
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors, of formula (I). In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specif...
|
|
WO/1994/005615A1 |
3-Azidomethyl-3-nitratomethyloxetane, a novel oxetane compound, is used as a monomer for the formation of homopolymers and copolymers with other known energetic oxetane monomers. The polyethers of the present invention can be subsequentl...
|
|
WO/1994/005281A1 |
Compounds of structure (1) where Ar is optionally substituted carbocyclic aryl, 5- or 6-membered heterocyclic aryl, 10-membered bicyclic heterocyclic aryl containing one or two nitrogen atoms, 9- or 10-membered heterocyclic containing on...
|
|
WO/1994/004519A1 |
A process for the preparation of a compound of formula (II) where R1 = H or R1 = COCH3, comprising contacting a mixture containing at least one taxane compound having an ester linkage at the C-13 position with at least one borohydride re...
|
|
WO/1994/001425A1 |
Novel taxane derivatives of general formula (I), preparation thereof and pharmaceutical compositions containing them are disclosed. In the formula Ar is an aryl radical, R is a phenyl radical or an R1-O- radical in which R1 is an optioni...
|
|
WO/1994/000156A1 |
A polymer conjugate consisting essentially of: from 90 to 99.9 mol % of units represented by formula (a); from 0.1 to 5 mol % of units represented by formula (b), wherein one of R1 and R2 is a copolymer residue of formula (c), and the ot...
|
|
WO/1993/024476A1 |
In accordance with the present invention, there are provided polymeric drug delivery systems in which the drug is bound to a water-soluble polymer to provide a form of soluble drug delivery especially for those cases in which the drug by...
|
|
WO/1993/024492A1 |
Besides the usual excipients and additives, a medicament contains a compound having formula (I), in which A and B, which are the same or different, each stand for a phenyl residue substituted if desired by halogen, hydroxy, C¿1?-C¿6? a...
|
|
WO/1993/023555A1 |
Successful culture methods have been developed which result in stable, long-term tissue cultures derived from Taxus explants and hydroponically grown roots. These cultures offer a rapidly reproducible, continuously-available source for t...
|
|
WO/1993/023389A1 |
Novel taxane derivatives of formula (I), their preparation and pharmaceutical compositions containing same. In general formula (I), Ar is an aryl radical, R1 is a hydrogen atom or an acetyl radical or a radical according to formula (II) ...
|
|
WO/1993/021173A1 |
Compounds having formula (I) wherein -OR?1¿ comprises the C-13 side-chain of taxol and R?3¿ comprises hydrogen, as well as a method for the preparation thereof.
|
|
WO/1993/021338A1 |
Taxol is produced from a taxol-producing microorganism. Radioactive labelled taxol products and methods for use of the radioactive labelled taxol are described.
|
|
WO/1993/020036A1 |
The present invention provides two basic routes for the total synthesis of taxol having structure (I). The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates ...
|
