Heterocyclic Compounds

Matches 1,751 - 1,800 out of 9,193	< 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 >

Document	Document Title
WO/2001/038319A1	DIOXOLONE AND ITS USE AS ELECTROLYTES According to the invention, 1,3-dioxol-(4)-ones can be used as solvents for lithium batteries. The invention also relates to novel dioxolones.
WO/2001/037826A1	NPYY5 ANTAGONISTS NPYY5 receptor antagonists which contain compounds represented bygeneral formula (I), prodrugs thereof, pharmaceutically acceptable salts thereof or solvates of the same wherein R?1¿ represents lower alkyl, cycloalkyl, etc.; R?2¿ repre...
WO/2001/036403A1	UREA DERIVATIVES AS ANTI-INFLAMMATORY AGENTS Disclosed are novel aromatic compounds of formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chr...
WO/2001/032602A1	DIARYL-ENYNES Provided, among other things, is a compound of Formula (I), wherein, Ar¿1? and Ar¿2? are independently selected aryl groups, optionally substituted with up to five substituents independently selected from the group consisting of alkyl,...
WO/2001/032609A1	NOVEL COMPOUNDS HAVING CYANO AND INSECTICIDES AND MITICIDES Compounds represented by general formula (1), a process for producing the same and insecticides and miticides containing as the active ingredient the above compounds or salts thereof wherein A represents one member selected from among th...
WO/2001/032654A2	NOVEL HETEROCYCLIC COMPOUNDS AND THEIR USE AS MEDICINES The invention concerns novel heterocyclic derivatives having a calpain inhibiting activity and/or an activity trapping reactive oxygen species, of formula (I) wherein A, X, Y, R?1¿, R?2¿ and Het represent variable groups. The invention...
WO/2001/030734A1	NOVEL HYDRONAPHTALENE COMPOUNDS, PREPARED BY A RHODIUM CATALYZED RING OPENING REACTION IN THE PRESENCE OF PHOSPHINE LIGAND The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a cat...
WO/2001/030149A1	NOVEL SUCCINIC ACID METALLO-BETA-LACTAMASE INHIBITORS AND THEIR USE IN TREATING BACTERIAL INFECTIONS This invention relates to novel substituted succinic acid metallo-$g(b)-lactamase inhibitors which are useful potentiators of $g(b)-lactam antibiotics. Accordingly, the present invention provides a method of treating bacterial infections...
WO/2001/030733A1	PROCESS FOR PREPARING $g(b)-KETOESTER ACETAL Process for the preparation of $g(b)-ketoester acetal through acetalyzation of $g(b)-ketoester with alkylglycol, characterized in that the acetalyzation is carried out in the presence of an acid catalyst selected in the group comprised o...
WO/2001/030745A1	ANTHRANILIC ACID DERIVATIVES AS INHIBITORS OF THE CGMP-PHOSPHODIESTERASE This invention relates to a compound of formula (I): wherein R?1¿ is nitro group, amino group, cyano group, a halo(lower)alkyl group, a halogen atom, etc., R?2¿ is an optionally substituted aryl group, A is a lower alkylene group, and ...
WO/2001/028979A2	INHIBITORS OF NEURAMINIDASES Disclosed are compounds of formula (I), (II) or (III) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and...
WO/2001/028990A2	METHODS OF ASYMMETRICALLY SYNTHESIZING ENANTIOMERS OF CASODEX, ITS DERIVATIVES AND INTERMEDIATES THEREOF A method of synthesizing pure enantiomers of acylanalides such as Casodex$m(3) (bicalutamide) and its derivatives includes contacting a compound having a ring structure that, when opened, provides a substituent having the structure of Fo...
WO/2001/027100A1	PROCESS FOR THE PREPARATION OF 3,4-METHYLENEDIOXY-MANDELIC ACID A process for preparing 3,4-methylenedioxymandelic acid by reacting 1,2-methylenedioxybenzene with glyoxylic acid in the presence of a strong acid, characterized in that the reaction is conducted in the presence of an aprotic organic sol...
WO/2001/025225A2	ADDUCTS OF GLYCIDYLESTERS OF ALPHA, ALPHA-BRANCHED CARBOXYLIC ACIDS AND ACRYLIC ACIDS AND POLY(ORTHO ESTER) AS INTERMEDIATE FOR THEIR PREPARATION Poly(ortho ester) intermediate of general formula (I) wherein R¿1?, R¿2? and R¿3? are the same or different and each may represent an alkyl group containing from 1 to 10 carbon atoms and preferably from 1 to 6, wherein n represents an...
WO/2001/025190A1	NOVEL DIARYLAMIDE DERIVATIVES AND USE THEREOF AS MEDICINES Diarylamide derivatives represented by general formula (1) or salts thereof, and pharmaceutical compositions containing the derivatives or the salts as the active ingredient, wherein A and B are each an aromatic ring such as benzene ring...
WO/2001/025179A1	PREPARATION OF TETRACYCLIC INTERMEDIATES The invention provides a process for preparing deoxytetracyclic compounds of formula (I) useful in the synthesis of anthracyclines by the rearrangement of thiono ester derivatives followed by reduction, as well as intermediates useful th...
WO/2001/025192A1	GUANIDINE DERIVATIVES AND THEIR USE IN THE PRODUCTION OF A MEDICAMENT FOR BLOCKING XANTHINE OXIDASE/DEHYDROGENASE The present invention relates to guanidine derivatives and pharmaceutically acceptable acid salts thereof. The invention further relates to pharmaceutical preparations containing said compounds, and the use of said compounds for treatmen...
WO/2001/023347A1	NOVEL AROMATIC COMPOUNDS The present invention relates to novel compounds of general formula (I), pharmaceutical formulations comprising these compounds, the use of these compounds as medicaments, the use of these medicaments in the treatment of and/or preventio...
WO/2001/021584A1	TYROSINE DERIVATIVES The compounds of the invention are inhibitors of alpha4 containing integrin-mediated binding to ligands such as VCAM-1 and MAdCAM.
WO/2001/021611A1	POLYORTHOESTER AND CURABLE COMPOSITION CONTAINING THE SAME A novel polyorthoester which is obtained by reacting (a) an orthoester such as methyl orthoformate, ethyl orthoformate, methyl orthoacetate, or ethyl orthoacetate, (b) at least one glycol compound selected among $g(a)-glycols and$g(b)-gl...
WO/2001/021577A2	MELANIN CONCENTRATING HORMONE ANTAGONIST A melanin-concentrating hormone antagonist which comprises a compound of formula (I) wherein Ar?1¿ is a cyclic group which may have substituents; X is a spacer having a main chain of 1 to 6 atoms; Y is a bond or a spacer having a main c...
WO/2001/021583A1	HYDROXAMIC ACID DERIVATIVES, PROCESS FOR THE PRODUCTION THEREOF AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT Hydroxamic acid derivatives represented by general formula (I), nontoxic salts thereof or prodrugs of the same (wherein each symbol is as defined in the description). Because of inhibiting the production of IL-6, the compounds of the gen...
WO/2001/019808A1	CHEMICAL COMPOUNDS AND COMPOSITIONS AND THEIR USE AS CATHEPSIN S INHIBITORS The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
WO/2001/019796A1	COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
WO/2001/019780A2	NOVEL DERIVATIVES OF DICARBOXYLIC ACID HAVING PHARMACEUTICAL PROPERTIES The invention relates to compounds of formula (I) as well as the salts and stereoisomers thereof used in the production of medicaments for the treatment of cardiovascular diseases.
WO/2001/017943A1	PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE Pharmaceutical compositions aryl substituted amine compounds, and in particular, 3-aminophenyl amine compounds are provided. Representative compounds are (4E)-N-methyl-5-(3-acetamido-4-methylphenyl)-4-penten-2-amin e, (4E)-N-methyl-5-(3-...
WO/2001/014320A1	COMPOUNDS THAT INHIBIT TRYPTASE ACTIVITY The present invention relates to compounds of Formula (I) or a pharmaceutically acceptable salt, solvate, hydrate or formulation thereof. These compounds can be used for the inhibition of tryptase and for the treatment and/or prevention ...
WO/2001/014362A1	FATTY ACID SYNTHASE INHIBITORS This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.
WO/2001/014355A1	SUBSTITUTED PIPERAZINE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR UTILIZATION AS MEDICAMENTS The invention relates to substituted piperazine derivatives of general formula (I), wherein R¿a? to R¿e? and n have the meaning defined in claim 1. The invention also relates to the isomers and salts of said substituted piperazine deri...
WO/2001/014328A2	SUBSTITUTED UREAS AS CELL ADHESION INHIBITORS Compounds of Formula (I) are antagonists of VLA-4 and/or $g(a)4$g(b)7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical ...
WO/2001/014303A1	TRIKETONE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND HERBICIDES CONTAINING THE SAME Triketone compounds represented by general formula (I) or salts thereof wherein W represents oxygen or sulfur; y is from 1 to 6; A represents an optionally alkylated 5- or 6-membered saturated heterocycle having 1 or 2 oxygen or sulfur a...
WO/2001/014363A1	FATTY ACID SYNTHASE INHIBITORS This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.
WO/2001/014364A1	FATTY ACID SYNTHASE INHIBITORS This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.
WO/2001/014371A1	N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS N-Heterocyclic derivatives of formula (Ya) are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibit...
WO/2001/012585A1	FUNGICIDAL COMPOUNDS HAVING A FLUOROVINYL- OR FLUOROPROPENYL-OXYPHENYLOXIME MOIETY AND PROCESS FOR THE PREPARATION THEREOF A fungicidal compound of formula (I) having a fluorovinye- or fluoropropenyl-oxyphenyloxime moiety and stereoisomers thereof are useful for protecting crops from fungal diseases: wherein, X is CH or N; Y is O or NH; R?1¿ is hydrogen, C�...
WO/2001/010843A1	4-(SUBSTITUTED PHENYL)-5-HALOPYRIMIDINE DERIVATIVES AND HERBICIDES CONTAINING THE SAME AS THE ACTIVE INGREDIENT 4-(Substituted phenyl)-5-halopyrimidines of general formula (I) useful as herbicides; and boron compounds of general formula (VI) useful as intermediates for the preparation thereof: wherein j and k are both 0, or alternaltively either o...
WO/2001/010816A2	SUBSTITUTED 2-DIALKYLAMINOALKYLBIPHENYL DERIVATIVES The invention relates to substituted 2-dialkylaminoalkylbiphenyl derivatives, a method for the preparation thereof, drugs containing them and the use thereof for the production of drugs.
WO/2001/010825A1	CARBAMATE DERIVATIVES AND AGRICULTURAL/HORTICULTURAL BACTERICIDES Novel bactericides having an excellent controlling effect on plant disease injury (in particular, wheat powdery mildew and cucumber gray mold) without exerting any undesirable effect on crops. Carbamate derivatives represented by general...
WO/2001/009088A1	UREA DERIVATIVES AS INHIBITORS OF CCR-3 RECEPTOR Urea and thiourea derivatives inhibit cell function of the chemokine receptor CCR-3. These compounds offer an effective means for treating a range of diseases thought to be mediated by the CCR-3 receptor. A variety of useful urea and thi...
WO/2001/007020A2	CARBOXYLIC ACID AMIDES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THE USE AND PRODUCTION THEREOF The invention relates to the use of carboxylic acid amides of general formula (I) for inhibiting telomerase, wherein A, B and R¿1? to R¿5? are defined as per claim (1). The invention also relates to novel carboxylic acid amides of gene...
WO/2001/004108A1	AMINO CERAMIDE-LIKE COMPOUNDS AND THERAPEUTIC METHODS OF USE Novel amino ceramide-like compounds (1) are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention ha...
WO/2001/004122A2	NEW 2,3-BENZODIAZEPINE DERIVATIVES The invention relates to new 2,3-benzodiazepine derivatives of general Formula (I), (wherein R?1¿ stands for methyl, formyl, carboxy, cyano, -CH=NOH, -CH=NNHCONH¿2? or -NR?5¿R?6¿, wherein R?5¿ and R?6¿ independently from each other...
WO/2001/002349A1	PHENYL SULFAMATE DERIVATIVES Phenyl sulfamate derivatives of general formula (I) or salts thereof, exhibiting an excellent steroid sulfatase inhibitory activity and being therefore effective in the prevention or treatment of diseases related to steroids including es...
WO/2001/002474A1	POLYCARBONATE COMPOSITION RESISTANT TO GAMMA RADIATION A thermoplastic polycarbonate molding composition having improved resistance to gamma radiation-induced yellowing is disclosed. Paricularly suitable for the manufacture of devices geared for medical applications, the composition contains...
WO/2001/000566A2	SUBSTITUTED PHENOXYACETIC ACIDS Disclosed are substituted phenoxyacetic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds, alone or in combination with other th...
WO/2000/078724A2	IMIDAZOLINDERIVATIVES THEIR PREPARATION AND THEIR PHARMACEUTICAL USE This invention relates to certain novel imidazoline compounds and analogues thereof, to their use for the treatment of diabetes, diabetic complications, metabolic disorders, or related diseases where impaired glucose disposal is present,...
WO/2000/077027A2	SERINE PROTEASE INHIBITORS Compounds of formula (I) where R¿2?, each X, L, Y, Cy, Lp, D and n are as defined in the specification, are serine protease (especially tryptase) inhibitors useful as antiinflammatory agents.
WO/2000/076970A2	SERINE PROTEASE INHIBITORS Use of compounds of formula (I) where R¿2?, each X, L, Y, Cy, Lp, D and n are as defined in the specification, as serine protease inhibitors.
WO/2000/076961A1	INHIBITORS OF ASPARTYL PROTEASE The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural an...
WO/2000/076991A1	PROCESS FOR PREPARING CHIRAL CYCLOPROPANE CARBOXYLIC ACIDS AND ACYL GUANIDINES A process is provided for preparing chiral cyclopropane carboxylic acids, preferably of structure (I) which are intermediates used in preparing acyl guanidine sodium/proton exchange (NHE) inhibitors.

Matches 1,751 - 1,800 out of 9,193	< 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 >