Heterocyclic Compounds

Matches 801 - 850 out of 30,770	< 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 >

Document	Document Title
WO/2022/249074A1	FUNGICIDAL COMPOSITION CONTAINING OXADIAZOLE COMPOUNDS The present invention discloses a novel fungicidal composition comprising at least one compound of formula (I) or an agriculturally acceptable salt thereof as a component (1), Formula (I) wherein, R, A, L1, R1, and n are as defined in th...
WO/2022/251496A1	RIGIDIFIED MACROCYCLES, COMPLEXES WITH RADIONUCLIDES, AND USE IN TARGETED RADIOTHERAPY OF CANCER The present technology provides compounds, as well as compositions including such compounds, useful in targeted radiotherapy of cancer and/or mammalian tissue overexpressing e.g., a glypican-3 (GPC3) receptor and/or prostate specific mem...
WO/2022/247796A1	USE OF CYCLIN-DEPENDENT KINASE 9 INHIBITOR Various applications of the compound represented by formula (I) or a pharmaceutically acceptable salt thereof, a stereoisomer, an isotope derivative, or a prodrug thereof as a cyclin-dependent kinase 9 (CDK9) inhibitor in the treatment o...
WO/2022/251482A1	ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF CANCER The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3‑kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): (I) or pharmaceut...
WO/2022/247786A1	ACID SALT OF CRYSTALLINE CSF-1R INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF Provided are an acid salt of a crystalline CSF-1R inhibitor, and a preparation method therefor and the use thereof, wherein the CSF-1R inhibitor is the compound 3,3-dimethyl-N-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyr idin-4-yl)oxy)p...
WO/2022/251359A1	BICYCLIC INHIBITORS OF ALK5 AND METHODS OF USE The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.
WO/2022/251584A1	METHODS AND COMPOSITIONS FOR TRANSDUCTION OF NK CELLS Disclosed are methods for transducing cells, e.g., NK cells, comprising: contacting the cells with a transduction composition, e.g., a virus particle, and a TBK1/IKKε inhibitor, e.g., the TBK1/IKKε inhibitor can comprise a substituted ...
WO/2022/247785A1	USE OF CYCLIN-DEPENDENT KINASE 9 INHIBITOR An application of a compound represented by formula (I) or a pharmaceutically acceptable salt, a stereoisomer, an isotopic derivative or a prodrug thereof in treating solid tumors, especially in treating liver cancer, breast cancer or pr...
WO/2022/250108A1	PHENYL UREA DERIVATIVE The present invention pertains to a therapeutic agent or preventative agent against diseases involving an orexin receptor, particularly an orexin type-2 receptor, the agent containing a novel compound having a urea skeleton, or a pharmac...
WO/2022/247919A1	COMPOUND USED AS BCR-ABL INHIBITOR Provided are a compound used as a BCR-ABL inhibitor, namely a compound of formula (I), or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition comprising the compound. Moreover, the ...
WO/2022/249203A1	NOVEL INTERMEDIATE FOR PREPARATION OF PYROXASULFONE The present invention relates to a novel a compound of formula (I) or its salt. The present invention further relates to process for preparation of Pyroxasulfone using said compound of formula (I) or its salt.
WO/2022/248887A1	2-CARBOXYL-INDOLE INHIBITORS OF METALLO-BETA-LACTAMASES The present invention relates to certain compounds that function as inhibitors of bacterial metallo-beta-lactamases. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions c...
WO/2022/243111A1	NEW SUBSTITUTED PYRIDINES AS FUNGICIDES The present invention relates to the compounds of formula (I) wherein the variables are defined as given in the description and claims. The invention further relates to their use and composition.
WO/2022/243655A1	DIFUNCTIONAL BIO-BENZOXAZINE COMPOUNDS, PREPARATION METHODS AND USES THEREOF The invention relates to a class of difunctional benzoxazine compounds useful as curatives, as well as methods of preparation, and uses thereof. The difunctional benzoxazine compounds comprise two benzoxazine rings, each disubstituted wi...
WO/2022/242639A1	RECEPTOR-INTERACTING PROTEIN INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF Provided are a compound as a receptor-interacting protein (RIP) inhibitor, a preparation method therefor, and a use thereof, relating to the field of chemical medicines. The compound is a compound as represented by formula (I), or a salt...
WO/2022/243109A1	NEW SUBSTITUTED QUINOLINES AS FUNGICIDES The present invention relates to the compounds of formula (I) wherein the variables are defined as given in the description and claims. The invention further relates to their use and composition.
WO/2022/242321A1	PI3Kα SELECTIVE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Disclosed are triazine ring benzoxazole compounds, a preparation method therefor and an application thereof, the structural formula of the compound being represented by formula I, or a pharmaceutically acceptable salt thereof. The presen...
WO/2022/243983A1	FUSED ISOXAZOLYL COMPOUNDS AS KAT6A INHIBITORS The present invention provides fused isoxazolyl compound of formula (I), which are therapeutically useful as KAT6A inhibitors particularly in the treatment and/or prevention of diseases or disorders dependent upon KAT6A in a mammal. The ...
WO/2022/245085A1	HETEROARYL DERIVATIVE COMPOUND AND USE THEREOF The present invention relates to a heteroaryl derivative and a use thereof. The heteroaryl derivative of the present invention exhibits excellent inhibitory activity against EGFR and/or HER2, and thus can be effectively used as a therape...
WO/2022/243107A1	NEW SUBSTITUTED PYRIDINES AS FUNGICIDES The present invention relates to the compounds of formula (I) wherein the variables are defined as given in the description and claims. The invention further relates to their use and composition.
WO/2022/239725A1	AGRICULTURAL AND HORTICULTURAL FUNGICIDAL COMPOSITION The problem addressed by the present invention is to provide an agricultural and horticultural fungicidal composition excelling in fungicidal activity, and for which there is no worry of phytotoxicity with respect to a useful plant.　Th...
WO/2022/238327A1	PYRIDINE DERIVATIVES WITH N-LINKED CYCLIC SUBSTITUENTS AS CGAS INHIBITORS The invention relates to new proline derivatives of formula (I) as cGAS inhibitors, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and G are defined as in claim 1, and prodrugs or pharmaceutically acceptable salts of these compound...
WO/2022/241278A1	SOLID FORMS OF A MODULATOR OF HEMOGLOBIN Forms of (S)-2-hydroxy-6-((4-(2-(2-hydroxyethyl)nicotinoyl)morpholin- 3-yl)methoxy)benzaldehyde (Compound I), or salts or solvates thereof, were prepared and characterized in the solid state. Also provided are processes of manufacture an...
WO/2022/241023A1	LPA RECEPTOR ANTAGONISTS AND USES THEREOF The application relates to triazole derivatives of the general Formula (I) that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The compounds are useful for the treatment of diseases and/or conditions th...
WO/2022/237858A1	COMPOUND HAVING ANTI-TUMOR ACTIVITY AND USE THEREOF Provided is a compound having anti-tumor activity and a use thereof. As a PRMT5 inhibitor, the compound has a structure represented by formula (I). Experiments have confirmed that these compounds have strong inhibitory effects on PRMT5 e...
WO/2022/241257A1	NAMPT INHBITORS AND USES THEREOF Disclosed are compounds, methods, compositions, uses, and kits that modulate (e.g., inhibit) nicotinamide phosphoribosyltransferase (NAMPT), the production of nicotinamide mononucleotide (NMN), the production of nicotinamide adenine dinu...
WO/2022/240876A1	POLO LIKE KINASE 4 INHIBITORS Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I),...
WO/2022/240830A1	C-LINKED INHIBITORS OF ENL/AF9 YEATS Compounds of Formula I and pharmaceutical compositions comprising compounds of Formula I are disclosed. Methods for treating acute leukemias using the compounds of Formula I and pharmaceutical compositions comprising the same are also di...
WO/2022/241172A1	SUBSTITUTED HETEROCYCLIC COMPOUNDS There are disclosed compounds of the following formula (I) or a stereoisomer or pharmaceutically acceptable salt thereof, wherein all substituents are as defined herein, which are useful in the modulation of IL-12, IL-23 and/or IFNα, by...
WO/2022/239798A1	(HETERO)ARYLAMIDE COMPOUND AND PEST CONTROL AGENT A compound represented by formula (I) or a salt thereof. In formula (I), Ar represents a substituted or unsubstituted C6-C10 aryl group, etc.; L1 represents a single bond, etc.; L2 represents a single bond, etc.; X1 represents a cyano gr...
WO/2022/241286A1	METHODS OF MAKING A MODULATOR OF HEMOGLOBIN The present disclosure relates to processes for preparing a compound of formula (I). The disclosure also provides compounds that are synthetic intermediates.
WO/2022/234470A1	NOVEL FUSED HETEROCYCLIC COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI The present invention relates to compounds of formula (I), Formula (I) wherein, R1, R2, Z1, Z2 and m are as defined in the detailed description, and a process for preparing such compounds of formula (I). The present invention also relate...
WO/2022/235754A1	LACTONE AND LACTAM CONTAINING COMPOUNDS USEFUL AS IMMUNOMODULATORS The present disclosure generally relates to lactone and lactam containing compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further perta...
WO/2022/235091A1	NOVEL HETEROCYCLIC COMPOUND AND USE THEREOF The present invention relates to a novel quinoline or quinazoline compound and the use thereof. The compound according to the present invention shows an excellent inhibitory activity against cytochrome P450 4A (CYP4A) and thus may be uti...
WO/2022/234271A1	HETEROARYL COMPOUNDS USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS The present invention provides compounds of formula (I), as well as pharmaceutically acceptable salts thereof: wherein X1, X2, X3, R3, Ring A and Ring B are as described herein. The compounds have affinity for α5-subunit-containing GABA...
WO/2022/235558A1	ARYL 3-OXOPIPERAZINE CARBOXAMIDES AND HETEROARYL 3-OXOPIPERAZINE CARBOXAMIDES AS NAV1.8 INHIBITORS Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression...
WO/2022/234965A1	HETEROARYL DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT The present invention relates to an isoxazolidin-2-yl-substituted heteroaryl derivative and a pharmaceutical composition for cancer prevention or treatment, comprising the compound as an active ingredient. The compound exhibits high inhi...
WO/2022/236253A1	HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS Heterocyclic compounds as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.
WO/2022/235717A1	BENZIMIDAZOYL GLP-1 RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS FOR THEIR USE Provided herein are GLP-1 receptor modulator compounds, pharmaceutical compositions, methods of their preparation, and methods of their use in treatment, and/or diagnosis.
WO/2022/233727A1	HERBICIDAL COMPOUNDS The present invention related to compounds of Formula (I) or an agronomically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 are as described herein. The invention further relates to compositions comprising said compounds, to met...
WO/2022/235575A1	ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3‑kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I) or pharmaceuticall...
WO/2022/235574A1	ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3 -kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I) or pharmaceutically...
WO/2022/235565A1	CLASS IIA HISTONE DEACETYLASE (HDAC) DEGRADER LIGANDS AND METHODS OF USE THEREOF The present invention relates to bifunctional compounds, compositions, and methods for treating diseases or conditions mediated by aberrant activity of at least one class IIa histone deacetylase (HDAC4/5/7/9).
WO/2022/235725A1	MODULATORS OF TREX1 Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositons thereof, which are useful for treating a variety of conditions associated with TREX1.
WO/2022/236257A1	HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS Heterocyclic compounds as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.
WO/2022/234069A1	NOVEL 2-AMINOOXAZOLES DERIVATIVES AND USE THEREOF FOR TREATING INFECTIOUS DISEASES This invention relates to 2-aminooxazole derivatives of general formula (I) or a pharmaceutically acceptable salt or solvate thereof wherein Y and Z are two different heteroatoms selected from N and O; X is selected from N and CR12; and ...
WO/2022/234193A1	NOVEL HETEROCYCLIC COMPOUNDS, COMPOSITIONS, METHODS OF PREPARATION AND USES THEREOF The present invention relates to compounds of formula (I),to salts, solvates and solvates of salts thereof, and to pharmaceutical compositions comprising these compounds as active ingredients. The invention further relates to their use a...
WO/2022/236118A1	FATTY ACID AMIDE HYDROLASE (FAAH) CLEAVABLE PRODRUGS OF BRAIN TARGETING ACTIVES AND COMBINATION WITH PERIPHERALLY RESTRICTED FAAH INHIBITORS Provided herein are fatty acid amide (FAAH) cleavable prodrugs of compounds that modulate a target in the brain including sphingosine- 1 -phosphate receptor (S1P1), lysophosphatidic acid receptor 1 (LPA1), G-protein coupled receptor 120 ...
WO/2022/226666A1	SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) The present application relates to substituted amino aza-heteroaryl compounds of Formula (I) and substituted aza-heteroaryl compounds of Formula II or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions c...
WO/2022/228218A1	APPLICATION OF QUINAZOLINE COMPOUND AND PHARMACEUTICAL COMPOSITION An application of a quinazoline compound and a pharmaceutical composition. The quinazoline compound is the quinazoline compound shown in formula A, a pharmaceutically acceptable salt thereof, a solvate thereof, or a solvate of the pharma...

Matches 801 - 850 out of 30,770	< 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 >