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Matches 651 - 700 out of 30,715

Document Document Title
WO/2023/025277A1
Provided are an aromatic ring-containing biological antagonist as represented by general formula (I) or a stereoisomer thereof, a preparation method therefor, a pharmaceutical composition containing same, and the use thereof in the prepa...  
WO/2023/028056A1
The invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein Z1, Z2, R3 - R8, RA, ring A, and n have the meanings described herein, and compositions containing such compounds and methods for usin...  
WO/2023/028564A1
The present disclosure relates generally to inhibitors of KIF18A, compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to indoline inhibitors of KIF18A and ...  
WO/2023/025201A1
A series of imidazocyclic compounds and an application thereof, which specifically relate to a compound represented by formula (P) and a pharmaceutically acceptable salt thereof.  
WO/2023/025136A1
Provided are an isoindolinone compound represented by structural formula (I) or a pharmaceutically acceptable salt thereof, and a use thereof in the treatment of proliferative diseases. Further provided is a pharmaceutical composition co...  
WO/2023/023942A1
Provided are compounds of Formula I, compositions comprising the compound of Formula I, and methods of using the same, in treating diseases, disorders, or conditions mediated by the inhibition of hematopoietic progenitor kinase 1 (HPK1).  
WO/2023/025915A1
The present invention is based on the finding that the compounds disclosed herein bind to, preferably harmful, protein-oligomers and thereby induce a conformational change of the latter. This conformational change enhances the recognitio...  
WO/2023/027948A1
The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of JAK2 enzymes with the compounds and compositions of the disclosure. The present disclosure further rela...  
WO/2023/026060A1
The present invention concerns Amyloid Binding Alcohol Dehydrogenase (ABAD) inhibitors (I) or (II) that interact non- competitively with nicotinamide adenine dinucleotide + H (NADH). Inhibition of ABAD is useful in the treatment or proph...  
WO/2023/025602A1
The invention relates to compounds of formula I I wherein the variables have the meanings as defined in the specification, to compositions com-prising them, to active compound combinations comprising them, and to their use for protecting...  
WO/2023/027032A1
Provided are a self degradation-type CDK9 inhibitor prodrug and a liposome encapsulating same. The present invention pertains to a compound represented by formula (1), or a pharmaceutically acceptable salt thereof [in the formula, R1 rep...  
WO/2023/025092A1
The present disclosure provides compounds of Formula I', compositions comprising the compound of Formula I', and methods of using the same, in treating diseases, disorders, or conditions mediated by the inhibition of certain kinases, suc...  
WO/2023/021278A1
This invention relates to novel compounds and pharmaceutical compositions comprising novel isoquinolone compounds. More specifically, the invention relates to compounds useful as inhibitors of discoidin domain receptor 1 (DDR1) and disco...  
WO/2023/021012A1
Suggested are compositions comprising substituted azacycles on one hand and physiological cooling or warming agents, flavors and/or fragrances on the other for masking, enhancing and/or boosting flavors, improving soothing ability, and i...  
WO/2023/023532A2
Compounds of formula (A) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6: Formula (A)  
WO/2023/022417A1
Provided is a cyano group-substituted heteroaryl amine derivative which effectively absorbs high-energy external light source in the UV region to minimize damage to organic materials inside an organic electroluminescent device, thus cont...  
WO/2023/020523A1
A compound of Formula (I), (II) or (III), stereoisomer thereof, pharmaceutically acceptable salt thereof, pharmaceutically acceptable salt of the stereoisomer are disclosed.  
WO/2023/016484A1
Provided is a sulfonamide derivate represented by the general formula (I), a preparation method thereof, a pharmaceutical composition containing said derivative, and the use thereof as a therapeutic agent, especially as a Lysine Acetyl T...  
WO/2023/017542A1
The present invention relates to a process for preparation of Pyroxasulfone substantially free of undesired impurity, by oxidizing a compound of formula (II) at a temperature ranging from 40 to 80°C.  
WO/2023/017699A1
The present invention addresses the problem of providing: a 3-substituted uracil compound that has excellent germicidal/antimicrobial activity and excellent safety, while being industrially beneficially synthesized; and an agricultural/h...  
WO/2023/016528A1
Disclosed are a class of benzomorpholine compounds, and a preparation method therefor and the use thereof. Specifically disclosed are a compound as represented by formula (I) and a pharmaceutically acceptable salt thereof. The compound h...  
WO/2023/018052A1
Provided is a tertiary amine derivative, which effectively absorbs a high-energy external light source in a UV region so as to minimize damage to organic materials in an organic electroluminescent device, and thus contributes to a substa...  
WO/2023/019148A1
Provided are enrichment methods. The methods may be used to enrich macromolecules. The enrichment may be performed with a multifunctional molecule. The multifunctional molecule may include any combination of a delivery moiety, a reactive...  
WO/2023/017452A1
The present invention relates to compounds of formula (I). The compounds maybe used to antagonise the Stimulator of Interferon Genes (STING) protein and may thereby treat liver fibrosis, fatty liver disease, non-alcoholic steatohepatitis...  
WO/2023/016530A1
Disclosed are a class of 3,4-dihydro-2H-benzo[b][1,4]oxazine compounds and a preparation method therefor, and an application of the compounds in the preparation of a drug for treating related diseases. Specifically disclosed are a compou...  
WO/2023/018040A1
Provided is a cyano group-substituted carbazole derivative, which effectively absorbs high energy external light source in a UV range so as to minimize damage to organic materials in an organic electroluminescent device, and thus contrib...  
WO/2023/018643A1
Provided herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, useful as RIPK1 inhibitors, and pharmaceutical compositions comprising same. Further provided are methods of use and preparation. (I)  
WO/2023/016440A1
Disclosed herein are compounds according to formula (I), the pharmaceutical composition comprising the same, and uses thereof.  
WO/2023/016521A1
Disclosed are a substituted triazole derivative, a preparation method therefor, a pharmaceutical composition thereof, and a use thereof; specifically, provided are a compound represented by general formula (I), cis-trans isomers thereof,...  
WO/2023/018806A1
The present disclosure provides processes for making enantiomerically pure compounds of formula (1), (1),.  
WO/2023/016525A1
An ATR kinase inhibitor as shown in formula I, and a preparation method therefor and the use thereof.  
WO/2023/017451A1
The present invention relates to compounds of formula (I). The compounds maybe used to antagonise the Stimulator of Interferon Genes (STING) protein and may thereby treat liver fibrosis, fatty liver disease, non-alcoholic steatohepatitis...  
WO/2023/011573A1
The present invention relates to an aromatic acetylene derivative, a preparation method therefor, and a medical use of a pharmaceutical composition containing the derivative. Specifically, the present invention relates to an aromatic ace...  
WO/2023/015184A1
Provided herein is a process for the preparation of (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden -1-yl)-1-methyl-1H-pyrazole-4-carboxamide, intermediates thereof, and salts of the foregoing.  
WO/2023/015138A1
The present disclosure relates to strapped calixpyrrole compounds, polymer monomers and polymers comprising strapped calixpyrrole substructures, and compositions thereof. Also provided herein are methods of use of said strapped calixpyrr...  
WO/2023/012044A1
A compound of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, which can be used as fungicides.  
WO/2023/014611A1
Pyrimidine compounds of formula (I) shown herein. Also disclosed are pharmaceutical compositions containing one of the pyrimidine compounds and methods of using the pyrimidine compounds to treat or prevent chemotherapy- induced periphera...  
WO/2023/011574A1
Disclosed in the present invention are an aromatic acetylene derivative, a preparation method therefor, a pharmaceutical composition containing the derivative, and the use of the aromatic acetylene derivative or the pharmaceutical compos...  
WO/2023/012821A1
The present invention provides a process for the preparation of a compound of Formula I, wherein, # indicates the attachment to isoxazoline ring and * indicates the attachment to the carbonyl carbon, The present invention particularly pr...  
WO/2023/011610A1
Provided are a benzodioxane compound, a preparation method therefor and an application thereof. Specifically, the present invention relates to a compound having EGFR inhibitory activity, a pharmaceutically acceptable salt or pharmaceutic...  
WO/2023/009503A1
Provided herein are photoactive fluorescent 2-diazo-3-oxo-2,3-dihydrospiro[indene-l,9'-xanthene] derivatives and other similar compounds of formula (I) for use in labeling proteins, for example, tagged proteins, and for use in visualizin...  
WO/2023/009585A2
Provided herein are compounds having activity against TTR related conditions, and pharmaceutically accepted salts and solvates thereof. Also provided are methods of using the compounds for inhibiting and preventing TTR aggregation and/or...  
WO/2023/008577A1
The present invention addresses the problem of providing a Ras/Raf binding inhibitor compound that has the effect of inhibiting Ras/Raf signaling in drug-resistant cancer cells and in a wide range of Ras mutant cancers. A Ras/Raf binding...  
WO/2023/009475A1
The present disclosure provides compounds of Formula (I) and (II), which may be R0CK2 inhibitors. The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, and methods of treating or preventing d...  
WO/2023/006019A1
Disclosed in the present invention are a polysubstituted benzene PD-L1 inhibitor, a composition and the use thereof. The compound has a structure as represented by general formula (I). The inventor of the present invention confirmed by m...  
WO/2023/003234A1
The present invention provides: a novel compound capable of improving the luminous efficiency, stability and lifespan of an element; an organic electric element using same; and an electronic device thereof.  
WO/2023/001298A1
The present invention relates to a method for preparing a hepatitis B virus nucleocapsid inhibitor. Specifically, the method of the present invention obtains a novel method for preparing a compound represented by formula (I) (each group ...  
WO/2023/001818A1
The invention relates to a compound having one of the following ionic chemical structures (I), "R" represents an "alkyl" or "O-alkyl" group optionally comprising one or more unsaturations, as a linear or branched chain, of 1 to 30 carbon...  
WO/2023/002443A1
The disclosure provides compounds of Formula (I): (I) as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certai...  
WO/2023/001299A1
The present invention relates to a crystal form of a compounds represented by formula (I), and preparation therefor and an application thereof. Specifically, also disclosed in the present invention are a variety of crystal forms of the c...  

Matches 651 - 700 out of 30,715